rexulti and Weed
Edited by Hugh Soames
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rexulti and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including rexulti. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing rexulti and Weed.
Mixing rexulti and Weed
Brexpiprazole, sold under the brand name Rexulti among others, is a medication used for the treatment of major depressive disorder, schizophrenia, and agitation associated with dementia due to Alzheimer’s disease. It is an atypical antipsychotic.
The most common side effects include akathisia (a constant urge to move) and weight gain. The most common side effects among people with agitation associated with dementia due to Alzheimer’s disease include headache, dizziness, urinary tract infection, nasopharyngitis, and sleep disturbances (both somnolence and insomnia).
Brexpiprazole was developed by Otsuka and Lundbeck, and is considered to be a successor to aripiprazole (Abilify). It was approved for medical use in the United States in July 2015. A generic version was approved in August 2022. Brexpiprazole is the first treatment approved by the US Food and Drug Administration (FDA) for agitation associated with dementia due to Alzheimer’s disease.
In the United States and Canada, brexpiprazole is indicated as an adjunctive therapy to antidepressants for the treatment of major depressive disorder and for the treatment of schizophrenia. In May 2023, the indication for brexpiprazole was expanded in the US to include the treatment of agitation associated with dementia due to Alzheimer’s disease.
In Australia and the European Union, brexpiprazole is indicated for the treatment of schizophrenia.
In 2020, it was approved in Brazil only as an adjunctive to the treatment of major depressive disorder.
The most common adverse events associated with brexpiprazole (all doses of brexpiprazole cumulatively greater than or equal to 5% vs. placebo) were upper respiratory tract infection (6.9% vs. 4.8%), akathisia (6.6% vs. 3.2%), weight gain (6.3% vs. 0.8%), and nasopharyngitis (5.0% vs. 1.6%). Brexpiprazole can cause impulse control disorders.
Brexpiprazole acts as a partial agonist of the serotonin 5-HT1A receptor and the dopamine D2 and D3 receptors. Partial agonists have both blocking properties and stimulating properties at the receptor they bind to. The ratio of blocking activity to stimulating activity determines a portion of its clinical effects. Brexpiprazole has more blocking and less stimulating activity at the dopamine receptors than its predecessor, aripiprazole, which may decrease its risk for agitation and restlessness. Specifically, where aripiprazole has an intrinsic activity or agonist effect at the D2 receptor of 60%+, brexpiprazole has an intrinsic activity at the same receptor of about 45%. For aripiprazole, this means more dopamine receptor activation at lower doses, with blockade being reached at higher doses, while brexpiprazole has the inverse effect because a partial agonist competes with dopamine. Brexpiprazole has a high affinity for the 5-HT1A receptor, acting as a potent antagonist at 5-HT2A receptors, and a potent partial agonist at dopamine D2 receptors with lower intrinsic activity compared to aripiprazole. In vivo characterization of brexpiprazole shows that it may act as a near-full agonist of the 5-HT1A receptor. This may further underlie a lower potential than aripiprazole to cause treatment-emergent, movement-related disorders such as akathisia due to the downstream dopamine release that is triggered by 5-HT1A receptor agonism. It is also an antagonist of the serotonin 5-HT2A, 5-HT2B, and 5-HT7 receptors, which may contribute to antidepressant effect. It also binds to and blocks the α1A-, α1B-, α1D-, and α2C-adrenergic receptors. The drug has negligible affinity for the muscarinic acetylcholine receptors, and hence has no anticholinergic effects. Although brexpiprazole has less affinity for H1 compared to aripiprazole, weight gain can occur.
Brexpiprazole was in clinical trials for adjunctive treatment of major depressive disorder, adult attention deficit hyperactivity disorder, bipolar disorder, schizophrenia, and agitation associated with dementia due to Alzheimer’s disease.
The phase II multicenter, double-blind, placebo-controlled study randomized 429 adult MDD patients who exhibited an inadequate response to one to three approved antidepressant treatments (ADTs) in the current episode. The study was designed to assess the efficacy and safety of brexpiprazole as an adjunctive treatment to standard antidepressant treatment. The antidepressants included in the study were desvenlafaxine, escitalopram, fluoxetine, paroxetine, sertraline, and venlafaxine.
A phase III study was in the recruiting stage: “Study of the Safety and Efficacy of Two Fixed Doses of OPC-34712 as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder (the Polaris Trial)”. Its goal is “to compare the effect of brexpiprazole to the effect of placebo (an inactive substance) as add on treatment to an assigned FDA approved antidepressant treatment (ADT) in patients with major depressive disorder who demonstrate an incomplete response to a prospective trial of the same assigned FDA approved ADT”. Estimated enrollment was 1250 volunteers.
The effectiveness of brexpiprazole for the treatment of agitation associated with dementia due to Alzheimer’s disease was determined through two 12-week, randomized, double-blind, placebo-controlled, fixed-dose studies. In these studies, participants were required to have a probable diagnosis of Alzheimer’s dementia; have a score between 5 and 22 on the Mini-Mental State Examination, a test that detects whether a person is experiencing cognitive impairment; and exhibit the type, frequency, and severity of agitation behaviors that require medication. Trial participants ranged between 51 and 90 years of age.
In January 2018, it was approved for the treatment of schizophrenia in Japan.
In November 2011, Otsuka Pharmaceutical and Lundbeck announced a global alliance. Lundbeck gave Otsuka an upfront payment of $200 million, and the deal includes development, regulatory and sales payments, for a potential total of $1.8 billion.[citation needed] Specifically for OPC-34712, Lundbeck will obtain 50% of net sales in Europe and Canada and 45% of net sales in the US from Otsuka.
Brexpiprazole was under development for the treatment of attention deficit hyperactivity disorder (ADHD) as an adjunct to stimulants, but was discontinued for this indication. It reached phase II clinical trials for this use prior to discontinuation.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between rexulti and Weed and an increase in anxiety.
Anyone mixing rexulti and weed is likely to experience side effects. This happens with all medications whether weed or rexulti is mixed with them. Side effects can be harmful when mixing rexulti and weed. Doctors are likely to refuse a patient a rexulti prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of rexulti and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including rexulti are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of rexulti. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, rexulti and Weed, dol not interact is wrong. There will always be an interaction between rexulti and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing rexulti and Weed is Scromiting. This condition, reportedly caused by mixing rexulti and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing rexulti and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and rexulti and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of rexulti?
The way in which the body absorbs and process rexulti may be affected by weed. Therefore, the potency of the rexulti may be less effective. Marijuana inhibits the metabolization of rexulti. Not having the right potency of rexulti means a person may either have a delay in the relief of their underlying symptoms.
A person seeking rexulti medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right rexulti medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of rexulti and Weed
Many individuals may not realize that there are side effects and consequences to mixing rexulti and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix rexulti and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing rexulti and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of rexulti and Weed is not recommended.
Taking rexulti and Weed together
People who take rexulti and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of rexulti and weed depend on whether you consume more weed in relation to rexulti or more rexulti in relation to weed.
The use of significantly more weed and rexulti will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and rexulti may experience effects such as:
- reduced motor reflexes from rexulti and Weed
- dizziness from Weed and rexulti
- nausea and vomiting due to rexulti and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and rexulti leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and rexulti
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with rexulti this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and rexulti affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of rexulti and weed have a greater adverse effect yet leading medical recommendation is that smaller does of rexulti can be just as harmful and there is no way of knowing exactly how rexulti and weed is going to affect an individual before they take it.
Taking rexulti and weed together
People who take rexulti and weed together will experience the effects of both substances. The use of significantly more rexulti with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and rexulti may experience effects such as:
- reduced motor reflexes from rexulti and weed
- dizziness from weed and rexulti
- nausea and vomiting of the rexulti
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and rexulti leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs rexulti
Taking rexulti in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of rexulti and weed may have difficulty forming new memories. With weed vs rexulti in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of rexulti when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of rexulti and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
rexulti Vs Weed
Studies investigating the effects of drugs such as rexulti and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when rexulti and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and rexulti together.
When a small to medium amount of weed is combined with rexulti, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as rexulti.
How long after taking rexulti can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the rexulti has totally cleared your system before taking weed, even in small quantities.
Overdose on rexulti and weed
In the case of Overdose on rexulti or if you are worried after mixing rexulti and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much rexulti or mixed weed with rexulti then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of rexulti and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing rexulti and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use rexulti and weed. These individuals may not realize that there are side effects and consequences to consuming both rexulti, marijuana and a range of antidepressants.
Studies on weed, rexulti and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and rexulti
A lot of people suffer from depression caused by weed and rexulti. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing rexulti and weed
Quitting weed to take rexulti
Medical professionals say an individual prescribed or taking rexulti should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take rexulti.
A person beginning to use rexulti should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and rexulti can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and rexulti may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing rexulti and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing rexulti or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent rexulti from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with rexulti.
If you take rexulti, and also drink Alcohol or MDMA, you can research the effects of rexulti and Alcohol , rexulti and Cocaine as well as rexulti and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
rexulti and Weed
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