Pioglitazone vs MDMA
Pioglitazone, sold under the brand name Actos among others, is an anti-diabetic medication used to treat type 2 diabetes. It may be used with metformin, a sulfonylurea, or insulin. Use is recommended together with exercise and diet. It is not recommended in type 1 diabetes. It is taken by mouth.
Common side effects include headaches, muscle pains, inflammation of the throat, and swelling. Serious side effects may include bladder cancer, low blood sugar, heart failure, and osteoporosis. Use is not recommended in pregnancy or breastfeeding. It is in the thiazolidinedione (TZD) class and works by improving sensitivity of tissues to insulin.
Pioglitazone was patented in 1985, and came into medical use in 1999. It is available as a generic medication. In 2019, it was the 179th most commonly prescribed medication in the United States, with more than 3 million prescriptions. It was withdrawn in France and Germany in 2011.
MDMA vs Pioglitazone
3,4-Methylenedioxymethamphetamine (MDMA), commonly seen in tablet form (ecstasy) and crystal form (molly or mandy), is a potent central nervous system (CNS) stimulant primarily used for recreational purposes. The desired effects include altered sensations, increased energy, empathy, and pleasure. When taken by mouth, effects begin in 30 to 45 minutes and last 3 to 6 hours.
MDMA was first developed in 1912 by Merck. It was used to enhance psychotherapy beginning in the 1970s and became popular as a street drug in the 1980s. MDMA is commonly associated with dance parties, raves, and electronic dance music. It may be mixed with other substances such as ephedrine, amphetamine, and methamphetamine. In 2016, about 21 million people between the ages of 15 and 64 used ecstasy (0.3% of the world population). This was broadly similar to the percentage of people who use cocaine or amphetamines, but lower than for cannabis or opioids. In the United States, as of 2017, about 7% of people have used MDMA at some point in their lives and 0.9% have used it in the last year.
Short-term adverse effects include grinding of the teeth, blurred vision, sweating and a rapid heartbeat, and extended use can also lead to addiction, memory problems, paranoia and difficulty sleeping. Deaths have been reported due to increased body temperature and dehydration. Following use, people often feel depressed and tired. MDMA acts primarily by increasing the activity of the neurotransmitters serotonin, dopamine and noradrenaline in parts of the brain. It belongs to the substituted amphetamine classes of drugs and has stimulant and hallucinogenic effects.
MDMA is illegal in most countries and has limited approved
medical uses in a small number of countries. In the United States, the Food and Drug Administration is currently evaluating the drug for clinical use. Canada has allowed limited distribution of MDMA and other psychedelics such as psilocybin upon application to and approval by Health Canada.
Overdose effects of Pioglitazone and MDMA
According to the most recent data, about 119,,000 people are treated for problems related to ecstasy and MDMA in emergency rooms in the United States alone. Furthermore, one study found that in 2019, there were 19,458 deaths from psychostimulants including MDMA.
But the answer to the question, “Can you overdose on ecstasy?” is not entirely straightforward. While it is possible to die as a result of ecstasy use, deaths from this drug are not necessarily a direct result of taking too much, but rather due to the side effects. And when mixing Pioglitazone and MDMA these side effects may be enhanced rapidly and exponentially.
According to medical experts, direct deaths from MDMA and Ecstasy use are usually down to overheating. The MDMA interferes with the body’s ability to regulate temperature and Pioglitazone interferes with this process even further. When people are then in warm environments or dancing, the risk of overheating is higher. The medical term for this is hyperthermia, and with hyperthermia people are at increased isk of:
- Swelling of the brain
- Muscle breakdown
- Electrolyte imbalances
- Organ failure
Pioglitazone and MDMA Emergencies
Many ecstasy “overdoses” are a direct result of additives in the pills themselves, such as Fentanly that we discussed earlier. When MDMA users arrive at a hospital or rehab center physicians and staff will not immediately know what per cent of the pills they’ve ingested was MDMA as opposed to other additives, or indeed what other substances (legal or illegal) have been ingested i.e. Pioglitazone and MDMA. This requires blood toxicology examinations and while the results are being waited on, medical professionals will do their best to treat dehydration and overheating1.
Once a patient is stabilized, there is a good chance of a full recovery. That being said, some cases of ecstasy overdose can be fatal, especially when Fentanyl and other highly dangerous cutting agents have been used.
If you have been using MDMA and ecstasy and find that it is difficult to stop, it is likely time to reach out for assistance. Don’t risk an overdose emergency or developing a chronic addiction.
If you take Pioglitazone, and also drink Alcohol or MDMA, you can research the effects of Pioglitazone and Alcohol as well as Pioglitazone and weed and Pioglitazone and Cocaine here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Other Drugs index A to L or Alcohol and Other Drugs index M to Z or our MDMA and Other Drugs Index A to L or MDMA and Other Drugs Index M to Z. or Cocaine and Other Drugs Index A to L or Cocaine and Other Drugs Index M to Z.
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If you are looking stop using either MDMA or Pioglitazone, you may experience withdrawal symptoms. MDMA withdrawal can be researched here and Pioglitazone withdrawal can be found on our Withdrawal index.
Find the best rehabs near you to help you with curing or controlling your addiction