paroxetine and Weed

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paroxetine and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including paroxetine. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing paroxetine and Weed.
Mixing paroxetine and Weed
Paroxetine, sold under the brand names Paxil and Seroxat among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used to treat major depressive disorder, obsessive-compulsive disorder, panic disorder, social anxiety disorder, posttraumatic stress disorder, generalized anxiety disorder and premenstrual dysphoric disorder. It has also been used in the treatment of premature ejaculation and hot flashes due to menopause. It is taken by mouth.
Common side effects include drowsiness, dry mouth, loss of appetite, sweating, trouble sleeping, and sexual dysfunction. Serious side effects may include suicidal thoughts in those under the age of 25, serotonin syndrome, and mania. While the rate of side effects appears similar compared to other SSRIs and SNRIs, antidepressant discontinuation syndromes may occur more often. Use in pregnancy is not recommended, while use during breastfeeding is relatively safe. It is believed to work by blocking the re-uptake of the chemical serotonin by neurons in the brain.
Paroxetine was approved for medical use in the United States in 1992 and initially sold by GlaxoSmithKline. It is on the World Health Organization’s List of Essential Medicines. It is available as a generic medication. In 2019, it was the 78th most commonly prescribed medication in the United States, with more than 9 million prescriptions. In 2018, it was in the top 10 of most prescribed antidepressants in the United States. In 2012, the United States Department of Justice fined GlaxoSmithKline $3 billion for withholding data, unlawfully promoting use in those under 18, and preparing an article that misleadingly reported the effects of paroxetine in adolescents with depression following its clinical trial study 329.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between paroxetine and Weed and an increase in anxiety.
Anyone mixing paroxetine and weed is likely to experience side effects. This happens with all medications whether weed or paroxetine is mixed with them. Side effects can be harmful when mixing paroxetine and weed. Doctors are likely to refuse a patient a paroxetine prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of paroxetine and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including paroxetine are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of paroxetine. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, paroxetine and Weed, dol not interact is wrong. There will always be an interaction between paroxetine and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing paroxetine and Weed is Scromiting. This condition, reportedly caused by mixing paroxetine and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing paroxetine and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and paroxetine and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of paroxetine?
The way in which the body absorbs and process paroxetine may be affected by weed. Therefore, the potency of the paroxetine may be less effective. Marijuana inhibits the metabolization of paroxetine. Not having the right potency of paroxetine means a person may either have a delay in the relief of their underlying symptoms.
A person seeking paroxetine medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right paroxetine medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of paroxetine and Weed
Many individuals may not realize that there are side effects and consequences to mixing paroxetine and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix paroxetine and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing paroxetine and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of paroxetine and Weed is not recommended.
Taking paroxetine and Weed together
People who take paroxetine and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of paroxetine and weed depend on whether you consume more weed in relation to paroxetine or more paroxetine in relation to weed.
The use of significantly more weed and paroxetine will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and paroxetine may experience effects such as:
- reduced motor reflexes from paroxetine and Weed
- dizziness from Weed and paroxetine
- nausea and vomiting due to paroxetine and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and paroxetine leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and paroxetine
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with paroxetine this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and paroxetine affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of paroxetine and weed have a greater adverse effect yet leading medical recommendation is that smaller does of paroxetine can be just as harmful and there is no way of knowing exactly how paroxetine and weed is going to affect an individual before they take it.
Taking paroxetine and weed together
People who take paroxetine and weed together will experience the effects of both substances. The use of significantly more paroxetine with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and paroxetine may experience effects such as:
- reduced motor reflexes from paroxetine and weed
- dizziness from weed and paroxetine
- nausea and vomiting of the paroxetine
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and paroxetine leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs paroxetine
Taking paroxetine in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of paroxetine and weed may have difficulty forming new memories. With weed vs paroxetine in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of paroxetine when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of paroxetine and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
paroxetine Vs Weed
Studies investigating the effects of drugs such as paroxetine and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when paroxetine and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and paroxetine together.
When a small to medium amount of weed is combined with paroxetine, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as paroxetine.
How long after taking paroxetine can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the paroxetine has totally cleared your system before taking weed, even in small quantities.
Overdose on paroxetine and weed
In the case of Overdose on paroxetine or if you are worried after mixing paroxetine and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much paroxetine or mixed weed with paroxetine then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of paroxetine and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing paroxetine and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use paroxetine and weed. These individuals may not realize that there are side effects and consequences to consuming both paroxetine, marijuana and a range of antidepressants.
Studies on weed, paroxetine and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and paroxetine
A lot of people suffer from depression caused by weed and paroxetine. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to underreporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing paroxetine and weed
Quitting weed to take paroxetine
Medical professionals say an individual prescribed or taking paroxetine should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take paroxetine.
A person beginning to use paroxetine should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and paroxetine can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and paroxetine may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing paroxetine and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing paroxetine or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent paroxetine from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with paroxetine.
If you take paroxetine, and also drink Alcohol or MDMA, you can research the effects of paroxetine and Alcohol , paroxetine and Cocaine as well as paroxetine and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.

paroxetine and Weed
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