pantoprazole and Weed

{Fulldrug} and Weed

Authored by Pin Ng PhD

Edited by Hugh Soames

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pantoprazole and Weed


Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including pantoprazole. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing pantoprazole and Weed.


Mixing pantoprazole and Weed


Pantoprazole, sold under the brand name Protonix, among others, is a proton pump inhibitor used for the treatment of stomach ulcers, short-term treatment of erosive esophagitis due to gastroesophageal reflux disease (GERD), maintenance of healing of erosive esophagitis, and pathological hypersecretory conditions including Zollinger–Ellison syndrome. It may also be used along with other medications to eliminate Helicobacter pylori. Effectiveness is similar to other proton pump inhibitors (PPIs). It is available by mouth and by injection into a vein.

Common side effects include headaches, diarrhea, vomiting, abdominal pain, and joint pain. More serious side effects may include severe allergic reactions, a type of chronic inflammation known as atrophic gastritis, Clostridium difficile colitis, low magnesium, and vitamin B12 deficiency. Use in pregnancy appears to be safe. Pantoprazole is a proton pump inhibitor that decreases gastric acid secretion. It works by inactivating (H+/K+)-ATPase function in the stomach.

Study of pantoprazole began in 1985, and it came into medical use in Germany in 1994. It is available as a generic medication. In 2020, it was the twentieth most commonly prescribed medication in the United States, with more than 26 million prescriptions.

Pantoprazole is used for short-term treatment of erosion and ulceration of the esophagus for adults and children five years of age and older caused by gastroesophageal reflux disease. It can be used as a maintenance therapy for long-term use after initial response is obtained, but there have not been any controlled studies about the use of pantoprazole past a duration of 12 months. Pantoprazole may also be used in combination with antibiotics to treat ulcers caused by Helicobacter pylori. It can also be used for long-term treatment of Zollinger-Ellison syndrome. It may be used to prevent gastric ulcers in those taking NSAIDs.

For improved efficacy of pantoprazole, the oral tablet formulation is taken half an hour prior to ingestion of food. In the hospital, intravenous administration is indicated when patients are unable to take the medication by mouth.

Pantoprazole is only indicated for the short-term treatment of erosive esophagitis in children ages seven and older; and the safety and effectiveness of pantoprazole have only been established in the treatment of erosive esophagitis in children.

The incidence of adverse effects occurring in people aged 65 years and older was similar to that in people aged 65 years and less.

In reproductive studies using doses largely greater than the recommended doses performed on rats and rabbits, there was no evident harm on the development of the baby.

Pantoprazole has been found to pass through the breast milk. Additionally, in rodent cancer studies, pantoprazole has been shown to potentially cause tumor growth. The clinical relevance of the finding is unknown, but risks and benefits are recommended for consideration in determining the use of therapy for the mother and child.

In people taking PPIs for longer than six months, a dose taper should be considered prior to discontinuation. For those on a moderate to high dose, this can be done by 50 percent every week until on the lowest dose. After a week it can then be stopped.

Due to its effect of reducing stomach acidity, use of pantoprazole can affect absorption of drugs that are pH-sensitive, such as ampicillin esters, ketoconazole, atazanavir, iron salts, amphetamine and mycophenolate mofetil. Additional medications that are affected include bisphosphonate derivatives, fluconazole, clopidogrel, and methotrexate.

The mechanism of action of pantoprazole is to inhibit the final step in gastric acid production. In the gastric parietal cell of the stomach, pantoprazole covalently binds to the H+/K+ ATP pump to inhibit gastric acid and basal acid secretion. The covalent binding prevents acid secretion for up to 24 hours and longer.

Pantoprazole is metabolized in the liver by the cytochrome P450 system. Metabolism mainly consists of demethylation by CYP2C19 followed by sulfation. Another metabolic pathway is oxidation by CYP3A4. Pantoprazole metabolites are not thought to have any pharmacological significance. It is usually given with a prokinetic drug because of inactivity in the acidic environment of the stomach. Pantoprazole binds irreversibly to H+K+ATPase (proton pumps) to suppress the secretion of acid. Due to irreversible binding of the pumps, new pumps have to be made before acid production can be resumed. The drug’s plasma half-life is about two hours. After administration, the time for the drug to reach peak plasma concentrations is 2 to 3 hours. The percentage of the drug that is protein bound is 98%.

In veterinary medicine, pantoprazole appears to be safe to use in several large animal species. The pharmacokinetics of pantoprazole have been explored in several veterinary species, including calves, alpacas and foals with half lives reported as 2.81, 0.47, and 1.43 hours, respectively. Pantoprazole appears to be eliminated more quickly in goats when compared to calves, with goats having an elimination half-life of less than one hour.

Pantoprazole was discovered by scientists at Byk Gulden, a subsidiary of Altana; the drug discovery program started in 1980, producing pantoprazole in 1985. The compound was actually created by chemists working on scale-up of a different chemical that had been chosen as a development candidate.: 117, 129  Byk Gulden partnered with Smith Kline & French in 1984.: 124  The compound’s development names were BY1029 and SK&F96022.: 123  By 1986 the companies had created the sodium salt, pantoprazole sodium sesquihydrate, and decided to develop it as it was more soluble and stable, and was more compatible with other ingredients used in the formulation.: 130  It was first marketed in Germany in 1994.: 130  Wyeth licensed the US patent from Altana, and obtained marketing approval from the US FDA in 2000 under the trade name Protonix.

In 2004, worldwide sales of the drug were $3.65 billion, about half of which were in the US.

In 2007, Altana’s drug business was acquired by Nycomed. Nycomed was in turn acquired by Takeda in 2011 and Wyeth was acquired by Pfizer in 2009.

The patent protecting the drug was set to expire in 2010, but Teva Pharmaceuticals filed an Abbreviated New Drug Application (ANDA) in 2007, and Wyeth and Nycomed sued Teva for patent infringement, but Teva decided to launch its generic drug “at risk” that year, before the patent had been invalidated. Wyeth launched an authorized generic in 2008. Pfizer and Takeda’s patent exclusivity expired in 2010, and an administrative exclusivity they had for pediatric use expired in January 2011, and full generic competition began. The litigation between Teva and Pfizer/Takeda was settled in 2013, with Teva paying the patent holders $2.15 billion in damages for its early launch.

As of 2017, the drug was marketed under many brands worldwide, including as a combination drug with domperidone, a combination with itopride, in combination with both clarithromycin and amoxicillin, in combination with levosulpiride, and in combination with naproxen.

Pantoprazole has been demonstrated to increase the 3rd compartment pH in alpacas. It has been shown to be generally safe to use in cattle, sheep and goats. The subcutaneous bioavailability is greater than 100% in calves. In calves intravenous and subcutaneous administration has been shown to significantly elevate abomasal pH.


Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between pantoprazole and Weed and an increase in anxiety.


Anyone mixing pantoprazole and weed is likely to experience side effects. This happens with all medications whether weed or pantoprazole is mixed with them. Side effects can be harmful when mixing pantoprazole and weed. Doctors are likely to refuse a patient a pantoprazole prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of pantoprazole and Weed.


Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including pantoprazole are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of pantoprazole. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, pantoprazole and Weed, dol not interact is wrong. There will always be an interaction between pantoprazole and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from


One of the milder side effects of mixing pantoprazole and Weed is Scromiting. This condition, reportedly caused by mixing pantoprazole and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing pantoprazole and Weed is cannabinoid hyperemesis syndrome, or CHS.  For these reasons, some people choose to quit smoking weed.


It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.


In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and pantoprazole and weed can cause health issues the more a person consumes it.


How does Weed effect the potency of pantoprazole?


The way in which the body absorbs and process pantoprazole may be affected by weed. Therefore, the potency of the pantoprazole may be less effective. Marijuana inhibits the metabolization of pantoprazole. Not having the right potency of pantoprazole means a person may either have a delay in the relief of their underlying symptoms.


A person seeking pantoprazole medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right pantoprazole medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.


Sideffects of pantoprazole and Weed


Many individuals may not realize that there are side effects and consequences to mixing pantoprazole and Weed such as:


  • Dizziness
  • Sluggishness
  • Drowsiness
  • Shortness of breath
  • Itching
  • Hives
  • Palpitations
  • Respiratory Depression
  • Cardiac Arrest
  • Coma
  • Seizures
  • Death


Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix pantoprazole and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing pantoprazole and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of pantoprazole and Weed is not recommended.


Taking pantoprazole and Weed together


People who take pantoprazole and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of pantoprazole and weed depend on whether you consume more weed in relation to pantoprazole or more pantoprazole in relation to weed.


The use of significantly more weed and pantoprazole will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.


People who take both weed and pantoprazole may experience effects such as:


  • reduced motor reflexes from pantoprazole and Weed
  • dizziness from Weed and pantoprazole
  • nausea and vomiting due to pantoprazole and Weed


Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and pantoprazole leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.

Mixing weed and pantoprazole


The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with pantoprazole this primary effect is exaggerated, increasing the strain on the body with unpredictable results.


Weed and pantoprazole affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of pantoprazole and weed have a greater adverse effect yet leading medical recommendation is that smaller does of pantoprazole can be just as harmful and there is no way of knowing exactly how pantoprazole and weed is going to affect an individual before they take it.


Taking pantoprazole and weed together


People who take pantoprazole and weed together will experience the effects of both substances. The use of significantly more pantoprazole with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.


People who take both weed and pantoprazole may experience effects such as:


  • reduced motor reflexes from pantoprazole and weed
  • dizziness from weed and pantoprazole
  • nausea and vomiting of the pantoprazole


Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and pantoprazole leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.

Weed Vs pantoprazole


Taking pantoprazole in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of pantoprazole and weed may have difficulty forming new memories. With weed vs pantoprazole in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of pantoprazole when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of pantoprazole and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from


pantoprazole Vs Weed


Studies investigating the effects of drugs such as pantoprazole and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when pantoprazole and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and pantoprazole together.


When a small to medium amount of weed is combined with pantoprazole, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as pantoprazole.


How long after taking pantoprazole can I smoke weed or take edibles?


To avoid any residual toxicity it is advisable to wait until the pantoprazole has totally cleared your system before taking weed, even in small quantities.


Overdose on pantoprazole and weed


In the case of Overdose on pantoprazole or if you are worried after mixing pantoprazole and weed, call a first responder or proceed to the nearest Emergency Room immediately.


If you are worried about someone who has taken too much pantoprazole or mixed weed with pantoprazole then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of pantoprazole and weed in their system.


Excessive Weed intake and result in scromiting, chs, and anxiety disorder.  It is advisable to quit vaping weed if you are feeling these symptoms.

Mixing pantoprazole and weed and antidepressants


Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use pantoprazole and weed. These individuals may not realize that there are side effects and consequences to consuming both pantoprazole, marijuana and a range of antidepressants.


Studies on weed, pantoprazole and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.


Self-medicating with Weed and pantoprazole


A lot of people suffer from depression caused by weed and pantoprazole. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.


Potential side effects from mixing pantoprazole and weed


Quitting weed to take pantoprazole


Medical professionals say an individual prescribed or taking pantoprazole should not stop using weed cold turkey.  Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take pantoprazole.


A person beginning to use pantoprazole should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.


Weed and pantoprazole can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and pantoprazole may include:


  • loss of motor skills
  • poor or lack of coordination
  • lowered blood pressure
  • short-term memory loss
  • increased heart rate
  • increased blood pressure
  • anxiety
  • paranoia
  • increased energy
  • increased motivation


Mixing pantoprazole and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing pantoprazole or other mental health drugs with weed can cause even more unwanted side effects.


Mixing drugs and weed conclusion


Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent pantoprazole from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with pantoprazole.


If you take pantoprazole, and also drink Alcohol or MDMA, you can research the effects of pantoprazole and Alcohol , pantoprazole and Cocaine as well as pantoprazole and MDMA here.


To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.

Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.


pantoprazole and Weed

pantoprazole and Weed

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  • 1
    1.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from
  • 2
    2.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from
  • 3
    3.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from