Nefazodone Withdrawal

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Nefazodone Withdrawal

Authored by Philippa Gold Edited by Hugh Soames


Must Read Disclaimer: We use fact-based content and publish material that is researched, cited, edited and reviewed by professionals. The information we publish is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.


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Nefazodone Withdrawal


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Nefazodone Withdrawal

What is Nefazodone


Nefazodone is one of the most widely abused drugs in North America and Worldwide. Addiction is nothing now, but what is new is the super worrying trend of increasing deaths due to Nefazodone overdose. In part, this can be said to be due to a number of factors such as:


  • Lack of education around Nefazodone
  • Increase in Pharmaceutical Prescriptions generally
  • A failure of Governments worldwide to do enough to stop Nefazodone addiction and related deaths
  • Societal thinking regarding addicts and Nefazodone addiction
  • Lack of Harm Reduction methods around Nefazodone usage
  • Lack of addiction related education in the medical professional


Further reading about Nefazodone from around the web

Nefazodone, sold formerly under the brand names Serzone, Dutonin, and Nefadar among others, is an atypical antidepressant medication which is used in the treatment of depression and for other uses. Nefazodone is still available in the United States, but was withdrawn from other countries due to rare liver toxicity. The medication is taken by mouth.

Side effects of nefazodone include dry mouth, sleepiness, nausea, dizziness, blurred vision, weakness, lightheadedness, confusion, and postural low blood pressure, among others. Rarely, nefazodone can cause serious liver damage, with an incidence of death or liver transplantation of about 1 in every 250,000 to 300,000 patient years. Nefazodone is a phenylpiperazine compound and is related to trazodone. It has been described as a serotonin antagonist and reuptake inhibitor (SARI) due to its combined actions as a potent antagonist of the serotonin 5-HT2A and 5-HT2C receptors and weak serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI).

beat withdrawal symptoms

beat withdrawal symptoms of Nefazodone

What Are Nefazodone Withdrawal Symptoms?


Withdrawal from Nefazodone is a serious matter. The effects on the body from Nefazodone use is extreme, and because of these effects Nefazodone withdrawal can very quickly become an acute medical emergency. Withdrawal from Nefazodone can cause a hypertensive crisis or myocardial infraction. In other words, a stroke or heart attack caused by sudden stoppage in taking Nefazodone or respiratory distress syndrome whereby your body shuts down from the lungs and respiratory system outwards.  Nefazodone withdrawal can also lead to serious anxiety and mental health related issues.


Never in any circumstances underestimate the seriousness of Nefazodone withdrawal1 If you are withdrawing from Nefazodone it is advisable to seek medical attention and in the case of medical emergency from Nefazodone withdrawal do not hesitate to head to the nearest Emergency Room.


Nefazodone withdrawal will vary for everyone and will be affected by several factors. The length and severity of Nefazodone use with be one of the main predictors of withdrawal symptoms and intensity. With Nefazodone withdrawal, it’s impossible to accurately predict how an individual will react to withdrawal.


Nefazodone Withdrawal Timeline


Full Nefazodone withdrawal often takes seven to fourteen days but sometimes longer, and the Nefazodone withdrawal symptoms are categorized according to their severity.


There are no minor symptoms of Nefazodone withdrawal. The first symptoms to exhibit themselves, usually 3-12 hours after Nefazodone withdrawal starts proper are headaches, tremors, sweating, itching, nausea, vomiting, diarrhea, fever and total confusion with anxiety or depression.


These are followed relatively quickly by the next stage in Nefazodone withdrawal timeline by:


  • Insomnia
  • Seizures
  • Hallucinations
  • Confusion
  • Tremors
  • Anxiety
  • Digestive discomfort
  • Headaches
  • Heart palpitations
  • Panic attacks
  • Muscle pain
  • Psychosis
  • Delirium tremens
  • Relapse


Worryingly, every time an individual attempts Nefazodone withdrawal the severity of symptoms tends to increase.


Nefazodone withdrawal has a mortality rate of between three and 19 per cent, depending on seriousness of Nefazodone usage.


Withdrawal from Nefazodone is a physically demanding process, in which the body will utilize every means possible to remove toxins, while creating psychological challenges because of the changes to the individuals brain chemistry.


Nefazodone Detox Process


The severity of Nefazodone detox makes it a process that should be approached carefully. Nefazodone Detox, especially for those with a heavy or long-lasting Nefazodone dependency, produces a range of symptoms and in extreme cases withdrawal can be fatal. However much they may want to end their addiction to Nefazodone, it’s vital to seek medical advice and enlist the support of their loved ones.


Nefazodone Withdrawal at a Rehab


Detoxing from Nefazodone within a treatment facility ensures medical help if it’s needed during the treatment process. Because Nefazodone rebound is a significant danger during withdrawal, having medical personnel present 24-hours a day can mean an instant response to any hypertensive or life-threatening crisis that may occur as a professional tapering process lowers the chances of patients experiencing fatal episodes.


Nefazodone withdrawal and detox begins with an initial medical exam to determine the patient’s physical condition upon entry into the rehab. This pre-detox Nefazodone withdrawal period can last up to 24 hours, as medical personnel determines both the patient’s general medical condition and drug history.


Detoxification of the patient’s body from Nefazodone begins after the pre-detox period ends. Medically assisted or tapered withdrawal from Nefazodone can take up to a few weeks to complete.

Rapid Detox from Nefazodone


Rapid detox from Nefazodone is a controversial topic and one that is unlikely to be accepted by everyone for its positive uses. It is a concept that has helped individuals addicted to Nefazodone and other drugs kick the habit and gain the help they need to live a healthier lifestyle.


A patient undergoing a rapid detox from Nefazodone is put under anesthesia for up to six hours. During this time, an opioid antagonist drug such as naltrexone is used to remove the Nefazodone from the patient’s body. Rapid detox can alleviate some of the more distressing symptoms of Nefazodone withdrawal.


The Nefazodone rapid detox method is used to stop a patient from feeling the devastating effects of Nefazodone withdrawal. Sedating the patient and putting them under anaesthesia allows them to “sleep” through the initial heavy Nefazodone withdrawal and detox process. The hope is that after the rapid detox process, the patient will wake up with their body completely clean of Nefazodone. The remainder of the withdrawal process will be minimal enabling the person to get on with the rehab process. Throughout rapid detox, the patient is monitored to ensure safety.


Does Nefazodone Rapid Detox Help Withdrawal Symptoms?


Experts claim that rapid detox from Nefazodone is a safe way to cleanse the body. It is also more pleasant as individuals who go through Nefazodone withdrawal can experience shakes, sweats, nausea, and other issues for long periods.


Nefazodone withdrawal can take weeks to fully complete. However, rapid detox from Nefazodone can take only a few days to a week at most. While the process of undergoing anaesthesia is just a few hours, Nefazodone detox patients can be kept in a medical clinic for monitoring afterwards. The process enables a patient to get – for many – the most difficult and frightening part of rehab out of the way. Once completed, patients can focus on the mental and emotional side of recovery.


For most Nefazodone addicts, the biggest barrier of attending rehab is withdrawal. The pain and distress Nefazodone withdrawal can have on a person can drive them back to using. Therefore, limiting or stopping a person’s physical Nefazodone withdrawal symptoms allows them to focus on making a full recovery.


By completing a residential rehab program following rapid detox, individuals can fully recover from their Nefazodone addiction.

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