Mercaptopurine and Weed

Advertising: We may earn a commission if you buy anything via our advertising or external links
Mercaptopurine and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Mercaptopurine. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Mercaptopurine and Weed.
Mixing Mercaptopurine and Weed
Mercaptopurine (6-MP), sold under the brand name Purinethol among others, is a medication used for cancer and autoimmune diseases. Specifically it is used to treat acute lymphocytic leukemia (ALL), acute promyelocytic leukemia (APL), Crohn’s disease, and ulcerative colitis. For acute lymphocytic leukemia it is generally used with methotrexate. It is taken by mouth.
Common side effects include bone marrow suppression, liver toxicity, vomiting, and loss of appetite. Other serious side effects include an increased risk of future cancer and pancreatitis. Those with a genetic deficiency in thiopurine S-methyltransferase are at higher risk of side effects. Use in pregnancy may harm the baby. Mercaptopurine
is in the thiopurine and antimetabolite family of medications.
Mercaptopurine was approved for medical use in the United States in 1953. It is on the World Health Organization’s List of Essential Medicines.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Mercaptopurine and Weed and an increase in anxiety.
Anyone mixing Mercaptopurine and weed is likely to experience side effects. This happens with all medications whether weed or Mercaptopurine is mixed with them. Side effects can be harmful when mixing Mercaptopurine and weed. Doctors are likely to refuse a patient a Mercaptopurine prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Mercaptopurine and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Mercaptopurine are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Mercaptopurine. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Mercaptopurine and Weed, dol not interact is wrong. There will always be an interaction between Mercaptopurine and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Mercaptopurine and Weed is Scromiting. This condition, reportedly caused by mixing Mercaptopurine and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Mercaptopurine and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Mercaptopurine and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Mercaptopurine?
The way in which the body absorbs and process Mercaptopurine may be affected by weed. Therefore, the potency of the Mercaptopurine may be less effective. Marijuana inhibits the metabolization of Mercaptopurine. Not having the right potency of Mercaptopurine means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Mercaptopurine medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Mercaptopurine medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Mercaptopurine and Weed
Many individuals may not realize that there are side effects and consequences to mixing Mercaptopurine and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Mercaptopurine and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Mercaptopurine and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Mercaptopurine and Weed is not recommended.
Taking Mercaptopurine and Weed together
People who take Mercaptopurine and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Mercaptopurine and weed depend on whether you consume more weed in relation to Mercaptopurine or more Mercaptopurine in relation to weed.
The use of significantly more weed and Mercaptopurine will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Mercaptopurine may experience effects such as:
- reduced motor reflexes from Mercaptopurine and Weed
- dizziness from Weed and Mercaptopurine
- nausea and vomiting due to Mercaptopurine and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Mercaptopurine leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Mercaptopurine
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Mercaptopurine this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Mercaptopurine affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Mercaptopurine and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Mercaptopurine can be just as harmful and there is no way of knowing exactly how Mercaptopurine and weed is going to affect an individual before they take it.
Taking Mercaptopurine and weed together
People who take Mercaptopurine and weed together will experience the effects of both substances. The use of significantly more Mercaptopurine with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Mercaptopurine may experience effects such as:
- reduced motor reflexes from Mercaptopurine and weed
- dizziness from weed and Mercaptopurine
- nausea and vomiting of the Mercaptopurine
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Mercaptopurine leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Mercaptopurine
Taking Mercaptopurine in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Mercaptopurine and weed may have difficulty forming new memories. With weed vs Mercaptopurine in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Mercaptopurine when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Mercaptopurine and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Mercaptopurine Vs Weed
Studies investigating the effects of drugs such as Mercaptopurine and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Mercaptopurine and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Mercaptopurine together.
When a small to medium amount of weed is combined with Mercaptopurine, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Mercaptopurine.
How long after taking Mercaptopurine can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Mercaptopurine has totally cleared your system before taking weed, even in small quantities.
Overdose on Mercaptopurine and weed
In the case of Overdose on Mercaptopurine or if you are worried after mixing Mercaptopurine and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Mercaptopurine or mixed weed with Mercaptopurine then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Mercaptopurine and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Mercaptopurine and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Mercaptopurine and weed. These individuals may not realize that there are side effects and consequences to consuming both Mercaptopurine, marijuana and a range of antidepressants.
Studies on weed, Mercaptopurine and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Mercaptopurine
A lot of people suffer from depression caused by weed and Mercaptopurine. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to underreporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Mercaptopurine and weed
Quitting weed to take Mercaptopurine
Medical professionals say an individual prescribed or taking Mercaptopurine should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Mercaptopurine.
A person beginning to use Mercaptopurine should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Mercaptopurine can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Mercaptopurine may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Mercaptopurine and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Mercaptopurine or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Mercaptopurine from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Mercaptopurine.
If you take Mercaptopurine, and also drink Alcohol or MDMA, you can research the effects of Mercaptopurine and Alcohol , Mercaptopurine and Cocaine as well as Mercaptopurine and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.

Mercaptopurine and Weed
Counselling for Weed Addiction; Low Cost - Qualified Therapists - Available Now - 20% Off
Betterhelp is for anyone suffering from mental health issues. Whether you suffer from anxiety, depression, weed addiction, eating disorders, or just need someone to speak to, Betterhelp can pair you with a qualified therapist.
In the wake of the pandemic, an increasing number of people have sought out therapeutic and conseling services to help with weed cessation. Better Help has seen a massive rise in people seeking help over the last two to three years.
If you or someone you care about is smoking or ingesting a level of weed that makes their life become unmanageable, Betterhelp has counselors and therapists on hand to help for less that $90 per week.
Specializations | Burnout, Anxiety, Depression, Stress, Anger Management, Dependencies, Grief, Seasonal Depressive Disorder, Life Crisis, Smoking Cessation, Weed Cessation (among others)
Betterhelp Cost | The standard fee for BetterHelp therapy is only $60 to $90 per week or $240 to $360 per month.
Key Takeaways |
- Largest online therapy platform
- Low cost
- Good for stopping weed
- Messaging
- Live video
- Phone calls
- Live chat
- No lock in contracts
- Cancel anytime
- Licensed and accredited therapists
Discounts Available | We have negotiated a generous 20% discount for readers of our website. Press Here to get 20% Off