Dimenhydrinate and Weed
Edited by Hugh Soames
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Dimenhydrinate and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Dimenhydrinate. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Dimenhydrinate and Weed.
Mixing Dimenhydrinate and Weed
Dimenhydrinate, sold under the brand name Dramamine, among others, is an over-the-counter medication used to treat motion sickness and nausea. Dimenhydrinate is a theoclate salt composed of diphenhydramine, an ethanolamine derivative, and 8-chlorotheophylline, a chlorinated theophylline derivative, in a 1:1 ratio.
Dimenhydrinate was introduced to the market by G.D. Searle in 1949.
Dimenhydrinate is an over-the-counter (OTC) antihistamine indicated for the prevention and relief of nausea and vomiting from a number of causes, including motion-sickness and post-operative nausea.
Common side effects may include:
Continuous and/or cumulative use of anticholinergic medications, including first-generation antihistamines, is associated with higher risk of cognitive decline and dementia in older people.
Diphenhydramine is the primary constituent of dimenhydrinate and dictates the primary effect. The main difference relative to pure diphenhydramine is a lower potency due to being combined with 8-chlorotheophylline. By weight, dimenhydrinate is between 53% and 55.5% diphenhydramine. Diphenhydramine is an H1 receptor antagonist that demonstrates anticholinergic activity.
The diphenhydramine component requires about 2 hours to reach peak concentration after either oral or sublingual administration of diphenhydrinate and has a half-life of 5 – 6 hours in healthy adults.
Dimenhydrinate is recreationally used as a deliriant. Slang terms for Dramamine used this way include “drama”, “dime”, “dime tabs”, “D-Q”, “substance D”, “d-house”, and “drams”. Abusing Dramamine is sometimes referred to as Dramatizing or “going a dime a dozen”, a reference to the amount of Dramamine tablets generally necessary for a trip.
Many users report a side-effect profile consistent with tropane alkaloid (e.g. atropine) poisoning as both show antagonism of muscarinic acetylcholine receptors in both the central and autonomic nervous system, which inhibits various signal transduction pathways.
Other CNS effects occur within the limbic system and hippocampus, causing confusion and temporary amnesia due to decreased acetylcholine signaling. Toxicology also manifests in the autonomic nervous system, primarily at the neuromuscular junction, resulting in ataxia and extrapyramidal side effects and the feeling of heaviness in the legs, and at sympathetic post-ganglionic junctions, causing urinary retention, pupil dilation, tachycardia, irregular urination, and dry red skin caused by decreased exocrine gland secretions, and mucous membranes. Considerable overdosage can lead to myocardial infarction (heart attack), serious ventricular arrhythmias, coma, and death. Such a side effect profile is thought to give ethanolamine-class antihistamines a relatively low abuse liability.[citation needed] An antidote that can be used for dimenhydrinate poisoning is physostigmine.
Dimenhydrinate (then known as Compound 1694) was being tested as a potential treatment for hay fever and urticaria at Johns Hopkins Hospital in 1947 by allergists Dr. Leslie Gay and Dr. Paul Carliner. Among those who received the drug was a pregnant woman who had suffered from motion sickness her entire life. She remained symptom-free if she took dimenhydrinate a few minutes before boarding a trolley, whereas the placebo was ineffective. To confirm these findings, the following year, G.D. Searle & Co. conducted a trial in which dimenhydrinate or placebo was given to U.S. troops crossing the Atlantic during “a rough passage” in a converted freight ship, the General Ballou, for 10 days as a rescue therapy for sea sickness. The findings were positive, as were the findings of a second trial of mostly women on the ship’s return voyage. Gay and Carliner announced their discovery at a meeting of the Johns Hopkins Medical Society on February 14, 1949, as well as in the Bulletin of The Johns Hopkins Hospital. The New York Times, the Baltimore Sun, and other national newspapers covered the discovery, and Dramamine was made available in drugstores later that year.
Dimenhydrinate is marketed under many brand names: in the U.S., Mexico, Turkey, Serbia, and Thailand as Dramamine; in Ukraine as Driminate; in Canada, Costa Rica, and India as Gravol; in Iceland as Gravamin; in Russia and Croatia as Dramina; in South Africa and Germany as Vomex; in Australia and Austria as Vertirosan; in Brazil as Dramin; in Colombia as Mareol; in Ecuador as Anautin; in Hungary as Daedalon; in Indonesia as Antimo; in Italy as Xamamina or Valontan; in Peru as Gravicoll; in Poland and Slovakia as Aviomarin; in Portugal as Viabom, Vomidrine, and Enjomin; in Spain as Biodramina; in Israel as Travamin; and in Pakistan as Gravinate.
Modest Mouse produced a song titled “Dramamine” on their 1996 debut album This Is a Long Drive for Someone with Nothing to Think About. The song uses side effects of the drug as a metaphor for the deteriorating state of a personal relationship.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Dimenhydrinate and Weed and an increase in anxiety.
Anyone mixing Dimenhydrinate and weed is likely to experience side effects. This happens with all medications whether weed or Dimenhydrinate is mixed with them. Side effects can be harmful when mixing Dimenhydrinate and weed. Doctors are likely to refuse a patient a Dimenhydrinate prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Dimenhydrinate and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Dimenhydrinate are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Dimenhydrinate. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Dimenhydrinate and Weed, dol not interact is wrong. There will always be an interaction between Dimenhydrinate and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Dimenhydrinate and Weed is Scromiting. This condition, reportedly caused by mixing Dimenhydrinate and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Dimenhydrinate and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Dimenhydrinate and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Dimenhydrinate?
The way in which the body absorbs and process Dimenhydrinate may be affected by weed. Therefore, the potency of the Dimenhydrinate may be less effective. Marijuana inhibits the metabolization of Dimenhydrinate. Not having the right potency of Dimenhydrinate means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Dimenhydrinate medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Dimenhydrinate medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Dimenhydrinate and Weed
Many individuals may not realize that there are side effects and consequences to mixing Dimenhydrinate and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Dimenhydrinate and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Dimenhydrinate and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Dimenhydrinate and Weed is not recommended.
Taking Dimenhydrinate and Weed together
People who take Dimenhydrinate and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Dimenhydrinate and weed depend on whether you consume more weed in relation to Dimenhydrinate or more Dimenhydrinate in relation to weed.
The use of significantly more weed and Dimenhydrinate will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Dimenhydrinate may experience effects such as:
- reduced motor reflexes from Dimenhydrinate and Weed
- dizziness from Weed and Dimenhydrinate
- nausea and vomiting due to Dimenhydrinate and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Dimenhydrinate leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Dimenhydrinate
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Dimenhydrinate this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Dimenhydrinate affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Dimenhydrinate and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Dimenhydrinate can be just as harmful and there is no way of knowing exactly how Dimenhydrinate and weed is going to affect an individual before they take it.
Taking Dimenhydrinate and weed together
People who take Dimenhydrinate and weed together will experience the effects of both substances. The use of significantly more Dimenhydrinate with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Dimenhydrinate may experience effects such as:
- reduced motor reflexes from Dimenhydrinate and weed
- dizziness from weed and Dimenhydrinate
- nausea and vomiting of the Dimenhydrinate
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Dimenhydrinate leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Dimenhydrinate
Taking Dimenhydrinate in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Dimenhydrinate and weed may have difficulty forming new memories. With weed vs Dimenhydrinate in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Dimenhydrinate when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Dimenhydrinate and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Dimenhydrinate Vs Weed
Studies investigating the effects of drugs such as Dimenhydrinate and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Dimenhydrinate and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Dimenhydrinate together.
When a small to medium amount of weed is combined with Dimenhydrinate, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Dimenhydrinate.
How long after taking Dimenhydrinate can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Dimenhydrinate has totally cleared your system before taking weed, even in small quantities.
Overdose on Dimenhydrinate and weed
In the case of Overdose on Dimenhydrinate or if you are worried after mixing Dimenhydrinate and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Dimenhydrinate or mixed weed with Dimenhydrinate then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Dimenhydrinate and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Dimenhydrinate and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Dimenhydrinate and weed. These individuals may not realize that there are side effects and consequences to consuming both Dimenhydrinate, marijuana and a range of antidepressants.
Studies on weed, Dimenhydrinate and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Dimenhydrinate
A lot of people suffer from depression caused by weed and Dimenhydrinate. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Dimenhydrinate and weed
Quitting weed to take Dimenhydrinate
Medical professionals say an individual prescribed or taking Dimenhydrinate should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Dimenhydrinate.
A person beginning to use Dimenhydrinate should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Dimenhydrinate can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Dimenhydrinate may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Dimenhydrinate and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Dimenhydrinate or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Dimenhydrinate from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Dimenhydrinate.
If you take Dimenhydrinate, and also drink Alcohol or MDMA, you can research the effects of Dimenhydrinate and Alcohol , Dimenhydrinate and Cocaine as well as Dimenhydrinate and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Dimenhydrinate and Weed
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