capecitabine and Weed

Edited by Hugh Soames
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capecitabine and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including capecitabine. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing capecitabine and Weed.
Mixing capecitabine and Weed
Capecitabine, sold under the brand name Xeloda among others, is a anticancer medication used to treat breast cancer, gastric cancer and colorectal cancer. For breast cancer it is often used together with docetaxel. It is taken by mouth.
Common side effects include abdominal pain, vomiting, diarrhea, weakness, and rashes. Other severe side effects include blood clotting problems, allergic reactions, heart problems such as cardiomyopathy, and low blood cell counts. Use during pregnancy may result in harm to the fetus. Capecitabine, inside the body, is converted to 5-fluorouracil (5-FU) through which it acts. It belongs to the class of medications known as fluoropyrimidines, which also includes 5-FU and tegafur.
Capecitabine was patented in 1992 and approved for medical use in 1998. It is on the World Health Organization’s List of Essential Medicines.
Capecitabine is indicated for
Adverse effects by frequency:
Notes on adverse effects:
Contraindications include:
Drugs it is known to interact with include:
The dihydropyrimidine dehydrogenase (DPD) enzyme is responsible for the detoxifying metabolism of fluoropyrimidines, a class of drugs that includes capecitabine, 5-fluorouracil and tegafur. Genetic variations within the DPD gene (DPYD) can lead to reduced or absent DPD activity, and individuals who are heterozygous or homozygous for these variations may have partial or complete DPD deficiency; an estimated 0.2% of individuals have complete DPD deficiency. Those with partial or complete DPD deficiency have a significantly increased risk of severe or even fatal drug toxicities when treated with fluoropyrimidines; examples of toxicities include myelosuppression, neurotoxicity and hand-foot syndrome.
Click on genes, proteins and metabolites below to link to respective articles.
Capecitabine is metabolised to 5-FU which in turn is a thymidylate synthase inhibitor, hence inhibiting the synthesis of thymidine monophosphate (ThMP), the active form of thymidine which is required for the de novo synthesis of DNA.
One of the brand names is Xeloda, marketed by Genentech.
Others include Xitabin, Capcibin, Kapetral and Pecaset by Eurolab.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between capecitabine and Weed and an increase in anxiety.
Anyone mixing capecitabine and weed is likely to experience side effects. This happens with all medications whether weed or capecitabine is mixed with them. Side effects can be harmful when mixing capecitabine and weed. Doctors are likely to refuse a patient a capecitabine prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of capecitabine and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including capecitabine are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of capecitabine. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, capecitabine and Weed, dol not interact is wrong. There will always be an interaction between capecitabine and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing capecitabine and Weed is Scromiting. This condition, reportedly caused by mixing capecitabine and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing capecitabine and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and capecitabine and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of capecitabine?
The way in which the body absorbs and process capecitabine may be affected by weed. Therefore, the potency of the capecitabine may be less effective. Marijuana inhibits the metabolization of capecitabine. Not having the right potency of capecitabine means a person may either have a delay in the relief of their underlying symptoms.
A person seeking capecitabine medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right capecitabine medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of capecitabine and Weed
Many individuals may not realize that there are side effects and consequences to mixing capecitabine and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix capecitabine and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing capecitabine and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of capecitabine and Weed is not recommended.
Taking capecitabine and Weed together
People who take capecitabine and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of capecitabine and weed depend on whether you consume more weed in relation to capecitabine or more capecitabine in relation to weed.
The use of significantly more weed and capecitabine will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and capecitabine may experience effects such as:
- reduced motor reflexes from capecitabine and Weed
- dizziness from Weed and capecitabine
- nausea and vomiting due to capecitabine and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and capecitabine leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and capecitabine
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with capecitabine this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and capecitabine affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of capecitabine and weed have a greater adverse effect yet leading medical recommendation is that smaller does of capecitabine can be just as harmful and there is no way of knowing exactly how capecitabine and weed is going to affect an individual before they take it.
Taking capecitabine and weed together
People who take capecitabine and weed together will experience the effects of both substances. The use of significantly more capecitabine with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and capecitabine may experience effects such as:
- reduced motor reflexes from capecitabine and weed
- dizziness from weed and capecitabine
- nausea and vomiting of the capecitabine
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and capecitabine leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs capecitabine
Taking capecitabine in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of capecitabine and weed may have difficulty forming new memories. With weed vs capecitabine in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of capecitabine when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of capecitabine and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
capecitabine Vs Weed
Studies investigating the effects of drugs such as capecitabine and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when capecitabine and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and capecitabine together.
When a small to medium amount of weed is combined with capecitabine, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as capecitabine.
How long after taking capecitabine can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the capecitabine has totally cleared your system before taking weed, even in small quantities.
Overdose on capecitabine and weed
In the case of Overdose on capecitabine or if you are worried after mixing capecitabine and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much capecitabine or mixed weed with capecitabine then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of capecitabine and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing capecitabine and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use capecitabine and weed. These individuals may not realize that there are side effects and consequences to consuming both capecitabine, marijuana and a range of antidepressants.
Studies on weed, capecitabine and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and capecitabine
A lot of people suffer from depression caused by weed and capecitabine. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing capecitabine and weed
Quitting weed to take capecitabine
Medical professionals say an individual prescribed or taking capecitabine should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take capecitabine.
A person beginning to use capecitabine should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and capecitabine can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and capecitabine may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing capecitabine and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing capecitabine or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent capecitabine from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with capecitabine.
If you take capecitabine, and also drink Alcohol or MDMA, you can research the effects of capecitabine and Alcohol , capecitabine and Cocaine as well as capecitabine and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.

capecitabine and Weed
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