candesartan and Weed
Edited by Hugh Soames
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candesartan and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including candesartan. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing candesartan and Weed.
Mixing candesartan and Weed
Candesartan is an angiotensin receptor blocker used mainly for the treatment of high blood pressure and congestive heart failure. Candesartan has a very low maintenance dose. Like Olmesartan, the metabolism of the drug is unusual as it is a cascading prodrug. Candesartan has good bioavailibility and is the most potent by weight of the AT-1 receptor antagonists.
It was patented in 1990 and approved for medical use in 1997.
As with other angiotensin II receptor antagonists, candesartan is indicated for the treatment of hypertension. Candesartan has an additive antihypertensive effect when combined with a diuretic, such as chlorthalidone. It is available in a fixed-combination formulation with a low dose of the thiazide diuretic hydrochlorothiazide. Candesartan/hydrochlorothiazide combination preparations are marketed under various trade names including Atacand Plus, Hytacand, Blopress Plus, Advantec and Ratacand Plus.
In heart failure patients, angiotensin receptor blockers such as candesartan and valsartan may be a suitable option for those who do not tolerate angiotensin-converting enzyme inhibitor medicines. Randomised control trials have shown candesartan reduces heart failure hospitalisations and cardiovascular deaths for patients who have heart failure with reduced left ventricular ejection fraction (LVEF ≤ 40%).
In a four-year randomized controlled trial, candesartan was compared to placebo to see whether it could prevent or postpone the development of full-blown hypertension in people with so-called prehypertension. During the first two years of the trial, half of participants were given candesartan while the other half received placebo; candesartan reduced the risk of developing hypertension by nearly two-thirds during this period. In the last two years of the study, all participants were switched to placebo. By the end of the study, candesartan had significantly reduced the risk of hypertension, by more than 15%. Serious adverse effects were more common among participants receiving placebo than in those given candesartan.
In 2005, meta-analysis results showed that angiotensin receptor blockers and angiotensin converting enzyme inhibitors considerably reduce the risk of atrial fibrillation in patients with coexisting heart failure and systolic left ventricular dysfunction. Specifically, an analysis of the CHARM study showed benefits for Candesartan in reducing new occurrences of atrial fibrillation in patients with heart failure and reduced left ventricular function. While these studies have demonstrated a potential additional benefit for candesartan when used in patients with systolic left ventricular dysfunction, additional studies are required to further elucidate the role of candesartan in the prevention of atrial fibrillation in other population groups.
Use of antihypertensive drugs has been demonstrated to slow the progression of diabetic retinopathy; the role of candesartan specifically in reducing progression in type 1 and type 2 diabetes is still up for debate. Results from a 2008 study on patients with type 1 diabetes showed there was no benefit in using candesartan to reduce progression of diabetic retinopathy when compared to placebo. Candesartan has been demonstrated to reverse the severity (cause regression) of mild to moderate diabetic retinopathy in patients with type 2 diabetes. The patient populations investigated in these studies were limited to mostly Caucasians and those younger than 75 years of age, so generalization of these findings to other population groups should be done with caution.
Candesartan may be helpful in migraine prevention as it has better tolerability and less side effects compared to other first line medications. It has been recommended by multiple guidelines for migraine prophylaxis in adults with different levels of recommendations, however further studies on larger populations are needed.
As with other drugs that inhibit the renin–angiotensin system, if candesartan is taken by pregnant women during the second or third trimester, it can cause injury and in some cases, death of the developing fetus. Symptomatic hypotension may occur in people who take candesartan and are volume-depleted or salt-depleted, as can also occur when diuretics are coadministered. Reduction in renal glomerular filtration rate may occur; people with renal artery stenosis may be at higher risk. Hyperkalemia may occur; people who are also taking spironolactone or eplerenone may be at higher risk.
Anemia may occur, due to inhibition of the renin–angiotensin system.
As with other angiotensin receptor blockers, candesartan can rarely cause severe liver injury.
Candesartan is marketed as the cyclohexyl 1-hydroxyethyl carbonate (cilexetil) ester, known as candesartan cilexetil. Candesartan cilexetil is metabolised completely by esterases in the intestinal wall during absorption to the active candesartan moiety. The first step that occurs in the cascading pro-drug mechanism of candesartan is that the carbonate gets hydrolyzed, releasing carbon dioxide. The metabolite at this step is cyclohexanol, and this is a relatively non-toxic compound which is advantageous to the design of the drug. The other aspect of the cascading prodrug is the O-CH-CH3 molecule which becomes converted into acetic acid, which is another product from the cascading side reaction. Similar to the insight from cyclohexanol, the metabolite of acetic acid relatively is non-toxic and thus less of a hazard if produced as the drug takes pharmacologic action.
The use of a prodrug form increases the bioavailability of candesartan. Despite this, absolute bioavailability is relatively poor at 15% (candesartan cilexetil tablets) to 40% (candesartan cilexetil solution). Its IC50 is 15 μg/kg. Candesartan is not administered in its active form because the administration of the pro-drug would require greater doses and has an unfavorable adverse event profile.
Candesartan is being investigated for its neuroprotective and anti-inflammatory properties. In an early Alzheimer’s disease mouse model, candesartan significantly reduced amyloid burden and inflammation and is being examined as a potential treatment for early Alzheimer’s. Rat models show that candesartan may have neuroprotective benefits that ameliorate certain central mechanisms of ageing and senescence. Candesartan has also demonstrated some possible therapeutic anti-stress and anti-anxiety applications. In a double-blind, placebo-controlled, randomized study, candesartan induced regression of left ventricular hypertrophy, and improved LV function and exercise tolerance with no side effects in patients with non obstructive hypertrophic cardiomyopathy.
The compound known as TCV-116 (candesartan) was studied by Japanese scientists using standard laboratory rats. Animal studies were published showing the effectiveness of the compound in 1992–1993, with a pilot study on humans published in the summer of 1993.
The prodrug candesartan cilexetil is marketed by AstraZeneca and Takeda Pharmaceuticals, commonly under the trade names Blopress, Atacand, Amias, and Ratacand. It is available in generic form.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between candesartan and Weed and an increase in anxiety.
Anyone mixing candesartan and weed is likely to experience side effects. This happens with all medications whether weed or candesartan is mixed with them. Side effects can be harmful when mixing candesartan and weed. Doctors are likely to refuse a patient a candesartan prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of candesartan and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including candesartan are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of candesartan. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, candesartan and Weed, dol not interact is wrong. There will always be an interaction between candesartan and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing candesartan and Weed is Scromiting. This condition, reportedly caused by mixing candesartan and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing candesartan and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and candesartan and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of candesartan?
The way in which the body absorbs and process candesartan may be affected by weed. Therefore, the potency of the candesartan may be less effective. Marijuana inhibits the metabolization of candesartan. Not having the right potency of candesartan means a person may either have a delay in the relief of their underlying symptoms.
A person seeking candesartan medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right candesartan medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of candesartan and Weed
Many individuals may not realize that there are side effects and consequences to mixing candesartan and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix candesartan and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing candesartan and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of candesartan and Weed is not recommended.
Taking candesartan and Weed together
People who take candesartan and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of candesartan and weed depend on whether you consume more weed in relation to candesartan or more candesartan in relation to weed.
The use of significantly more weed and candesartan will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and candesartan may experience effects such as:
- reduced motor reflexes from candesartan and Weed
- dizziness from Weed and candesartan
- nausea and vomiting due to candesartan and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and candesartan leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and candesartan
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with candesartan this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and candesartan affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of candesartan and weed have a greater adverse effect yet leading medical recommendation is that smaller does of candesartan can be just as harmful and there is no way of knowing exactly how candesartan and weed is going to affect an individual before they take it.
Taking candesartan and weed together
People who take candesartan and weed together will experience the effects of both substances. The use of significantly more candesartan with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and candesartan may experience effects such as:
- reduced motor reflexes from candesartan and weed
- dizziness from weed and candesartan
- nausea and vomiting of the candesartan
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and candesartan leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs candesartan
Taking candesartan in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of candesartan and weed may have difficulty forming new memories. With weed vs candesartan in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of candesartan when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of candesartan and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
candesartan Vs Weed
Studies investigating the effects of drugs such as candesartan and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when candesartan and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and candesartan together.
When a small to medium amount of weed is combined with candesartan, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as candesartan.
How long after taking candesartan can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the candesartan has totally cleared your system before taking weed, even in small quantities.
Overdose on candesartan and weed
In the case of Overdose on candesartan or if you are worried after mixing candesartan and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much candesartan or mixed weed with candesartan then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of candesartan and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing candesartan and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use candesartan and weed. These individuals may not realize that there are side effects and consequences to consuming both candesartan, marijuana and a range of antidepressants.
Studies on weed, candesartan and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and candesartan
A lot of people suffer from depression caused by weed and candesartan. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing candesartan and weed
Quitting weed to take candesartan
Medical professionals say an individual prescribed or taking candesartan should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take candesartan.
A person beginning to use candesartan should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and candesartan can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and candesartan may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing candesartan and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing candesartan or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent candesartan from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with candesartan.
If you take candesartan, and also drink Alcohol or MDMA, you can research the effects of candesartan and Alcohol , candesartan and Cocaine as well as candesartan and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
candesartan and Weed
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