bactrim and Weed
Edited by Hugh Soames
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bactrim and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including bactrim. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing bactrim and Weed.
Mixing bactrim and Weed
Trimethoprim/sulfamethoxazole, (also known as Cotrimoxazole) sold under the brand name Bactrim among others, is a fixed-dose combination antibiotic medication used to treat a variety of bacterial infections. It consists of one part trimethoprim to five parts sulfamethoxazole. It is used to treat urinary tract infections, methicillin-resistant Staphylococcus aureus (MRSA) skin infections, travelers’ diarrhea, respiratory tract infections, and cholera, among others. It is used both to treat and prevent pneumocystis pneumonia and toxoplasmosis in people with HIV/AIDS and other causes of immunosuppression. It can be given by mouth or intravenously.
Trimethoprim/sulfamethoxazole is on the World Health Organization’s List of Essential Medicines and is also available as a generic medication. In 2020, it was the 121st most commonly prescribed medication in the United States, with more than 5 million prescriptions.
Trimethoprim/sulfamethoxazole (TMP/SMX) is the medicine most commonly used to prevent Pneumocystis jirovecii pneumonia (PCP) People who get Pneumocystis pneumonia have a medical condition that weakens their immune system, like HIV/AIDS, or take medicines (such as corticosteroids) that reduce the body’s ability to fight bacterial and viral infections. People with HIV/AIDS are less likely to get Pneumocystis pneumonia as a result of antiretroviral therapy (ART). However, Pneumocystis pneumonia is still a substantial public health problem. Most of what is scientifically known about Pneumocystis pneumonia and its treatment comes from studying people with HIV/AIDS.
Organisms against which trimethoprim/sulfamethoxazole can be effective include:
The only notable nonsusceptible organisms are Pseudomonas aeruginosa, the mycoplasmae and Francisella tularensis (the causative organism of tularaemia).
Its use during pregnancy is contraindicated, although it has been placed in Australian pregnancy category C. Its use during the first trimester (during organogenesis) and 12 weeks prior to pregnancy has been associated with an increased risk of congenital malformations, especially malformations associated with maternal folic acid deficiency (which is most likely related to the mechanism of action of co-trimoxazole) such as neural tube defects such as spina bifida, cardiovascular malformations (e.g. Ebstein’s anomaly), urinary tract defects, oral clefts, and club foot in epidemiological studies. Its use later on during pregnancy also increases the risk of preterm labour (odds ratio: 1.51) and low birth weight (odds ratio: 1.67). Animal studies have yielded similarly discouraging results.
It appears to be safe for use during breastfeeding as long as the baby is healthy.
Its use in those less than 2 months of age is not recommended due to the risk of adverse side effects.
Common side effects include nausea, vomiting, rash, and diarrhea. Severe allergic reactions and Clostridium difficile infection may occasionally occur. Its use in pregnancy is not recommended. It appears to be safe for use during breastfeeding as long as the baby is healthy. Trimethoprim/sulfamethoxazole generally results in bacterial death. It works by blocking the making and use of folate by the microorganisms.
Contraindications include the following:
Its use is advised against in people being concomitantly treated with:
Likely signs of toxicity include:
The recommended treatment for overdose includes:
Alkalinisation of the urine may reduce the toxicity of sulfamethoxazole, but it may increase the toxic effects of trimethoprim.
The synergy between trimethoprim and sulfamethoxazole was first described in the late 1960s. Trimethoprim and sulfamethoxazole have a greater effect when given together than when given separately, because they inhibit successive steps in the folate synthesis pathway. They are given in a one-to-five ratio in their tablet formulations so that when they enter the body their concentration in the blood and tissues is roughly one-to-twenty — the exact ratio required for a peak synergistic effect between the two.
Sulfamethoxazole, a sulfonamide, induces its therapeutic effects by interfering with the de novo (that is, from within the cell) synthesis of folate inside microbial organisms such as protozoa, fungi and bacteria. It does this by competing with p-aminobenzoic acid (PABA) in the biosynthesis of dihydrofolate.
Trimethoprim serves as a competitive inhibitor of dihydrofolate reductase (DHFR), hence inhibiting the de novo synthesis of tetrahydrofolate, the biologically active form of folate.
Tetrahydrofolate is crucial in the synthesis of purines, thymidine, and methionine which are needed for the production of DNA and proteins during bacterial replication. Thus the net effect of each of these drugs is a bacteriostatic halt in replication. When combined, TMP and SMX are bactericidal.
The effects of trimethoprim causes a backlog of dihydrofolate (DHF) and this backlog can work against the inhibitory effect the drug has on tetrahydrofolate biosynthesis. This is where the sulfamethoxazole comes in; its role is in depleting the excess DHF by preventing it from being synthesised in the first place.
Co-trimoxazole was claimed to be more effective than either of its components individually in treating bacterial infections, although this was later disputed. Because it has a higher incidence of adverse effects, including allergic responses, its use has been restricted in many countries to very specific circumstances where its improved efficacy has been demonstrated. It may be effective in a variety of upper and lower respiratory tract infections, kidney and urinary tract infections, gastrointestinal tract infections, skin and wound infections, sepsis, and other infections caused by sensitive organisms. Co-trimoxazole decreases the risk of recurrence of retinochoroiditis. The global problem of advancing antimicrobial resistance has led to a renewed interest in the use of co-trimoxazole more recently.
Trimethoprim/sulfamethoxazole may be abbreviated as SXT, SMZ-TMP, TMP-SMX, TMP-SMZ, or TMP-sulfa.
Co-trimoxazole (British Approved Name (BAN)) is manufactured and sold by many different companies. The following list of brand names is incomplete:
Trimethoprim/sulfamethoxazole is relatively inexpensive as of 2019.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between bactrim and Weed and an increase in anxiety.
Anyone mixing bactrim and weed is likely to experience side effects. This happens with all medications whether weed or bactrim is mixed with them. Side effects can be harmful when mixing bactrim and weed. Doctors are likely to refuse a patient a bactrim prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of bactrim and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including bactrim are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of bactrim. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, bactrim and Weed, dol not interact is wrong. There will always be an interaction between bactrim and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing bactrim and Weed is Scromiting. This condition, reportedly caused by mixing bactrim and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing bactrim and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and bactrim and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of bactrim?
The way in which the body absorbs and process bactrim may be affected by weed. Therefore, the potency of the bactrim may be less effective. Marijuana inhibits the metabolization of bactrim. Not having the right potency of bactrim means a person may either have a delay in the relief of their underlying symptoms.
A person seeking bactrim medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right bactrim medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of bactrim and Weed
Many individuals may not realize that there are side effects and consequences to mixing bactrim and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix bactrim and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing bactrim and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of bactrim and Weed is not recommended.
Taking bactrim and Weed together
People who take bactrim and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of bactrim and weed depend on whether you consume more weed in relation to bactrim or more bactrim in relation to weed.
The use of significantly more weed and bactrim will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and bactrim may experience effects such as:
- reduced motor reflexes from bactrim and Weed
- dizziness from Weed and bactrim
- nausea and vomiting due to bactrim and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and bactrim leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and bactrim
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with bactrim this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and bactrim affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of bactrim and weed have a greater adverse effect yet leading medical recommendation is that smaller does of bactrim can be just as harmful and there is no way of knowing exactly how bactrim and weed is going to affect an individual before they take it.
Taking bactrim and weed together
People who take bactrim and weed together will experience the effects of both substances. The use of significantly more bactrim with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and bactrim may experience effects such as:
- reduced motor reflexes from bactrim and weed
- dizziness from weed and bactrim
- nausea and vomiting of the bactrim
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and bactrim leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs bactrim
Taking bactrim in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of bactrim and weed may have difficulty forming new memories. With weed vs bactrim in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of bactrim when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of bactrim and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
bactrim Vs Weed
Studies investigating the effects of drugs such as bactrim and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when bactrim and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and bactrim together.
When a small to medium amount of weed is combined with bactrim, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as bactrim.
How long after taking bactrim can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the bactrim has totally cleared your system before taking weed, even in small quantities.
Overdose on bactrim and weed
In the case of Overdose on bactrim or if you are worried after mixing bactrim and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much bactrim or mixed weed with bactrim then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of bactrim and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing bactrim and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use bactrim and weed. These individuals may not realize that there are side effects and consequences to consuming both bactrim, marijuana and a range of antidepressants.
Studies on weed, bactrim and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and bactrim
A lot of people suffer from depression caused by weed and bactrim. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing bactrim and weed
Quitting weed to take bactrim
Medical professionals say an individual prescribed or taking bactrim should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take bactrim.
A person beginning to use bactrim should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and bactrim can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and bactrim may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing bactrim and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing bactrim or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent bactrim from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with bactrim.
If you take bactrim, and also drink Alcohol or MDMA, you can research the effects of bactrim and Alcohol , bactrim and Cocaine as well as bactrim and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
bactrim and Weed
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