aniracetam and Weed
Edited by Hugh Soames
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aniracetam and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including aniracetam. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing aniracetam and Weed.
Mixing aniracetam and Weed
Aniracetam (brand names Draganon, Sarpul, Ampamet, Memodrin, Referan), also known as N-anisoyl-2-pyrrolidinone, is a racetam which is sold in Europe as a prescription drug. It is not approved by the Food and Drug Administration for use in the United States as a prescription medication or dietary supplement. Despite the FDA’s lack of approval, the drug is readily available over-the-counter in misbranded dietary supplements.
Aniracetam has been shown to positively modulate the AMPA receptor.
When ingested orally aniracetam is quickly broken down via first pass hepatic metabolism. The primary metabolites of aniracetam are N-anisoyl-GABA, (70–80%), 2-Pyrrolidinone and p-anisic acid (20–30%). There is some preliminary research suggesting that N-anisoyl-GABA and to a lesser degree p-ansic acid may contribute to the stimulatory effects of aniracetamin in rats. Further work in rats suggets that N-anisoyl-GABA may contribute more to increasing acetylcholine release than aniracetam itself. For instance, a study using the forced swim test in rats found that the two metabolites 2-pyrrolidinone and N-anisoyl-GABA alone yielded similar anti-depressant effects as aniracetam itself. The authors of the aforementioned study hypothesized that the metabolites work by increasing levels of dopamine and by stimulating the nicotinic acetylcholine receptors.
Plasma concentrations are generally in the 5–15 μg/L range for aniracetam and 5–15 mg/L range for N-anisoyl-GABA, a pharmacologically-active metabolite, during the first few hours after oral administration of the drug. These two plasma species may be measured by liquid chromatography-mass spectrometry.
The drug was first made in the 1970s by Hoffmann-La Roche. Synthesis can be accomplished by reacting 2-pyrrolidone with anisoyl chloride in the presence of triethylamine.
Alternatively, gamma-aminobutyric acid can react with anisoyl chloride. Ring closure can be accomplished in the presence of thionyl chloride.
Aniracetam is available by prescription in Greece (brand names Memodrin and Referan) and Italy (brand name Ampamet), where it is indicated for mental function disorders.
Aniracetam is a schedule 4 substance in Australia under the Poisons Standard (February 2020). A schedule 4 substance is classified as “Prescription Only Medicine, or Prescription Animal Remedy – Substances, the use or supply of which should be by or on the order of persons permitted by state or territory legislation to prescribe and should be available from a pharmacist on prescription.”
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between aniracetam and Weed and an increase in anxiety.
Anyone mixing aniracetam and weed is likely to experience side effects. This happens with all medications whether weed or aniracetam is mixed with them. Side effects can be harmful when mixing aniracetam and weed. Doctors are likely to refuse a patient a aniracetam prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of aniracetam and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including aniracetam are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of aniracetam. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, aniracetam and Weed, dol not interact is wrong. There will always be an interaction between aniracetam and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing aniracetam and Weed is Scromiting. This condition, reportedly caused by mixing aniracetam and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing aniracetam and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and aniracetam and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of aniracetam?
The way in which the body absorbs and process aniracetam may be affected by weed. Therefore, the potency of the aniracetam may be less effective. Marijuana inhibits the metabolization of aniracetam. Not having the right potency of aniracetam means a person may either have a delay in the relief of their underlying symptoms.
A person seeking aniracetam medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right aniracetam medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of aniracetam and Weed
Many individuals may not realize that there are side effects and consequences to mixing aniracetam and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix aniracetam and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing aniracetam and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of aniracetam and Weed is not recommended.
Taking aniracetam and Weed together
People who take aniracetam and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of aniracetam and weed depend on whether you consume more weed in relation to aniracetam or more aniracetam in relation to weed.
The use of significantly more weed and aniracetam will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and aniracetam may experience effects such as:
- reduced motor reflexes from aniracetam and Weed
- dizziness from Weed and aniracetam
- nausea and vomiting due to aniracetam and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and aniracetam leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and aniracetam
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with aniracetam this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and aniracetam affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of aniracetam and weed have a greater adverse effect yet leading medical recommendation is that smaller does of aniracetam can be just as harmful and there is no way of knowing exactly how aniracetam and weed is going to affect an individual before they take it.
Taking aniracetam and weed together
People who take aniracetam and weed together will experience the effects of both substances. The use of significantly more aniracetam with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and aniracetam may experience effects such as:
- reduced motor reflexes from aniracetam and weed
- dizziness from weed and aniracetam
- nausea and vomiting of the aniracetam
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and aniracetam leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs aniracetam
Taking aniracetam in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of aniracetam and weed may have difficulty forming new memories. With weed vs aniracetam in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of aniracetam when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of aniracetam and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
aniracetam Vs Weed
Studies investigating the effects of drugs such as aniracetam and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when aniracetam and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and aniracetam together.
When a small to medium amount of weed is combined with aniracetam, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as aniracetam.
How long after taking aniracetam can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the aniracetam has totally cleared your system before taking weed, even in small quantities.
Overdose on aniracetam and weed
In the case of Overdose on aniracetam or if you are worried after mixing aniracetam and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much aniracetam or mixed weed with aniracetam then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of aniracetam and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing aniracetam and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use aniracetam and weed. These individuals may not realize that there are side effects and consequences to consuming both aniracetam, marijuana and a range of antidepressants.
Studies on weed, aniracetam and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and aniracetam
A lot of people suffer from depression caused by weed and aniracetam. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing aniracetam and weed
Quitting weed to take aniracetam
Medical professionals say an individual prescribed or taking aniracetam should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take aniracetam.
A person beginning to use aniracetam should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and aniracetam can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and aniracetam may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing aniracetam and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing aniracetam or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent aniracetam from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with aniracetam.
If you take aniracetam, and also drink Alcohol or MDMA, you can research the effects of aniracetam and Alcohol , aniracetam and Cocaine as well as aniracetam and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
aniracetam and Weed
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