ampicillin and Weed
Edited by Hugh Soames
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ampicillin and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including ampicillin. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing ampicillin and Weed.
Mixing ampicillin and Weed
Ampicillin is an antibiotic belonging to the aminopenicillin class of the penicillin family. The drug is used to prevent and treat a number of bacterial infections, such as respiratory tract infections, urinary tract infections, meningitis, salmonellosis, and endocarditis. It may also be used to prevent group B streptococcal infection in newborns. It is used by mouth, by injection into a muscle, or intravenously.
Common side effects include rash, nausea, and diarrhea. It should not be used in people who are allergic to penicillin. Serious side effects may include Clostridium difficile colitis or anaphylaxis. While usable in those with kidney problems, the dose may need to be decreased. Its use during pregnancy and breastfeeding appears to be generally safe.
Ampicillin was discovered in 1958 and came into commercial use in 1961. It is on the World Health Organization’s List of Essential Medicines. The World Health Organization classifies ampicillin as critically important for human medicine. It is available as a generic medication.
Ampicillin used to also be used to treat gonorrhea, but there are now too many strains resistant to penicillins.
Ampicillin is used to treat infections by many gram-positive and gram-negative bacteria. It was the first “broad spectrum” penicillin with activity against gram-positive bacteria, including Streptococcus pneumoniae, Streptococcus pyogenes, some isolates of Staphylococcus aureus (but not penicillin-resistant or methicillin-resistant strains), Trueperella, and some Enterococcus. It is one of the few antibiotics that works against multidrug resistant Enterococcus faecalis and E. faecium. Activity against gram-negative bacteria includes Neisseria meningitidis, some Haemophilus influenzae, and some of the Enterobacteriaceae (though most Enterobacteriaceae and Pseudomonas are resistant). Its spectrum of activity is enhanced by co-administration of sulbactam, a drug that inhibits beta lactamase, an enzyme produced by bacteria to inactivate ampicillin and related antibiotics. It is sometimes used in combination with other antibiotics that have different mechanisms of action, like vancomycin, linezolid, daptomycin, and tigecycline.
Ampicillin can be administered by mouth, an intramuscular injection (shot) or by intravenous infusion. The oral form, available as capsules or oral suspensions, is not given as an initial treatment for severe infections, but rather as a follow-up to an IM or IV injection. For IV and IM injections, ampicillin is kept as a powder that must be reconstituted.
IV injections must be given slowly, as rapid IV injections can lead to convulsive seizures.
Ampicillin is one of the most used drugs in pregnancy, and has been found to be generally harmless both by the Food and Drug Administration in the U.S. (which classified it as category B) and the Therapeutic Goods Administration in Australia (which classified it as category A). It is the drug of choice for treating Listeria monocytogenes in pregnant women, either alone or combined with an aminoglycoside. Pregnancy increases the clearance of ampicillin by up to 50%, and a higher dose is thus needed to reach therapeutic levels.
Ampicillin crosses the placenta and remains in the amniotic fluid at 50–100% of the concentration in maternal plasma; this can lead to high concentrations of ampicillin in the newborn.
While lactating mothers secrete some ampicillin into their breast milk, the amount is minimal.
In newborns, ampicillin has a longer half-life and lower plasma protein binding. The clearance by the kidneys is lower, as kidney function has not fully developed.
Ampicillin is contraindicated in those with a hypersensitivity to penicillins, as they can cause fatal anaphylactic reactions. Hypersensitivity reactions can include frequent skin rashes and hives, exfoliative dermatitis, erythema multiforme, and a temporary decrease in both red and white blood cells.
Ampicillin is not recommended in people with concurrent mononucleosis, as over 40% of patients develop a skin rash.
Ampicillin is comparatively less toxic than other antibiotics, and side effects are more likely in those who are sensitive to penicillins and those with a history of asthma or allergies. In very rare cases, it causes severe side effects such as angioedema, anaphylaxis, and C. difficile infection (that can range from mild diarrhea to serious pseudomembranous colitis). Some develop black “furry” tongue. Serious adverse effects also include seizures and serum sickness. The most common side effects, experienced by about 10% of users are diarrhea and rash. Less common side effects can be nausea, vomiting, itching, and blood dyscrasias. The gastrointestinal effects, such as hairy tongue, nausea, vomiting, diarrhea, and colitis, are more common with the oral form of penicillin. Other conditions may develop up several weeks after treatment.
Ampicillin overdose can cause behavioral changes, confusion, blackouts, and convulsions, as well as neuromuscular hypersensitivity, electrolyte imbalance, and kidney failure.
Ampicillin reacts with probenecid and methotrexate to decrease renal excretion. Large doses of ampicillin can increase the risk of bleeding with concurrent use of warfarin and other oral anticoagulants, possibly by inhibiting platelet aggregation. Ampicillin has been said to make oral contraceptives less effective, but this has been disputed. It can be made less effective by other antibiotic, such as chloramphenicol, erythromycin, cephalosporins, and tetracyclines. For example, tetracyclines inhibit protein synthesis in bacteria, reducing the target against which ampicillin acts. If given at the same time as aminoglycosides, it can bind to it and inactivate it. When administered separately, aminoglycosides and ampicillin can potentiate each other instead.
Ampicillin causes skin rashes more often when given with allopurinol.
Both the live cholera vaccine and live typhoid vaccine can be made ineffective if given with ampicillin. Ampicillin is normally used to treat cholera and typhoid fever, lowering the immunological response that the body has to mount.
Ampicillin is in the penicillin group of beta-lactam antibiotics and is part of the aminopenicillin family. It is roughly equivalent to amoxicillin in terms of activity. Ampicillin is able to penetrate gram-positive and some gram-negative bacteria. It differs from penicillin G, or benzylpenicillin, only by the presence of an amino group. This amino group, present on both ampicillin and amoxicillin, helps these antibiotics pass through the pores of the outer membrane of gram-negative bacteria, such as E. coli, Proteus mirabilis, Salmonella enterica, and Shigella.
Ampicillin acts as an irreversible inhibitor of the enzyme transpeptidase, which is needed by bacteria to make the cell wall. It inhibits the third and final stage of bacterial cell wall synthesis in binary fission, which ultimately leads to cell lysis; therefore, ampicillin is usually bacteriolytic.
Ampicillin is well-absorbed from the GI tract (though food reduces its absorption), and reaches peak concentrations in one to two hours. The bioavailability is around 62% for parenteral routes. Unlike other penicillins, which usually bind 60–90% to plasma proteins, ampicillin binds to only 15–20%.
Ampicillin is distributed through most tissues, though it is concentrated in the liver and kidneys. It can also be found in the cerebrospinal fluid when the meninges become inflamed (such as, for example, meningitis). Some ampicillin is metabolized by hydrolyzing the beta-lactam ring to penicilloic acid, though most of it is excreted unchanged. In the kidneys, it is filtered out mostly by tubular secretion; some also undergoes glomerular filtration, and the rest is excreted in the feces and bile.
Hetacillin and pivampicillin are ampicillin esters that have been developed to increase bioavailability.
Ampicillin has been used extensively to treat bacterial infections since 1961. Until the introduction of ampicillin by the British company Beecham, penicillin therapies had only been effective against gram-positive organisms such as staphylococci and streptococci. Ampicillin (originally branded as “Penbritin”) also demonstrated activity against gram-negative organisms such as H. influenzae, coliforms, and Proteus spp.
Ampicillin is relatively inexpensive. In the United States, it is available as a generic medication.
In veterinary medicine, ampicillin is used in cats, dogs, and farm animals to treat:
Horses are generally not treated with oral ampicillin, as they have low bioavailability of beta-lactams.
The half-life in animals is around that same of that in humans (just over an hour). Oral absorption is less than 50% in cats and dogs, and less than 4% in horses.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between ampicillin and Weed and an increase in anxiety.
Anyone mixing ampicillin and weed is likely to experience side effects. This happens with all medications whether weed or ampicillin is mixed with them. Side effects can be harmful when mixing ampicillin and weed. Doctors are likely to refuse a patient a ampicillin prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of ampicillin and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including ampicillin are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of ampicillin. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, ampicillin and Weed, dol not interact is wrong. There will always be an interaction between ampicillin and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing ampicillin and Weed is Scromiting. This condition, reportedly caused by mixing ampicillin and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing ampicillin and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and ampicillin and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of ampicillin?
The way in which the body absorbs and process ampicillin may be affected by weed. Therefore, the potency of the ampicillin may be less effective. Marijuana inhibits the metabolization of ampicillin. Not having the right potency of ampicillin means a person may either have a delay in the relief of their underlying symptoms.
A person seeking ampicillin medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right ampicillin medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of ampicillin and Weed
Many individuals may not realize that there are side effects and consequences to mixing ampicillin and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix ampicillin and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing ampicillin and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of ampicillin and Weed is not recommended.
Taking ampicillin and Weed together
People who take ampicillin and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of ampicillin and weed depend on whether you consume more weed in relation to ampicillin or more ampicillin in relation to weed.
The use of significantly more weed and ampicillin will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and ampicillin may experience effects such as:
- reduced motor reflexes from ampicillin and Weed
- dizziness from Weed and ampicillin
- nausea and vomiting due to ampicillin and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and ampicillin leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and ampicillin
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with ampicillin this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and ampicillin affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of ampicillin and weed have a greater adverse effect yet leading medical recommendation is that smaller does of ampicillin can be just as harmful and there is no way of knowing exactly how ampicillin and weed is going to affect an individual before they take it.
Taking ampicillin and weed together
People who take ampicillin and weed together will experience the effects of both substances. The use of significantly more ampicillin with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and ampicillin may experience effects such as:
- reduced motor reflexes from ampicillin and weed
- dizziness from weed and ampicillin
- nausea and vomiting of the ampicillin
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and ampicillin leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs ampicillin
Taking ampicillin in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of ampicillin and weed may have difficulty forming new memories. With weed vs ampicillin in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of ampicillin when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of ampicillin and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
ampicillin Vs Weed
Studies investigating the effects of drugs such as ampicillin and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when ampicillin and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and ampicillin together.
When a small to medium amount of weed is combined with ampicillin, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as ampicillin.
How long after taking ampicillin can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the ampicillin has totally cleared your system before taking weed, even in small quantities.
Overdose on ampicillin and weed
In the case of Overdose on ampicillin or if you are worried after mixing ampicillin and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much ampicillin or mixed weed with ampicillin then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of ampicillin and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing ampicillin and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use ampicillin and weed. These individuals may not realize that there are side effects and consequences to consuming both ampicillin, marijuana and a range of antidepressants.
Studies on weed, ampicillin and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and ampicillin
A lot of people suffer from depression caused by weed and ampicillin. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing ampicillin and weed
Quitting weed to take ampicillin
Medical professionals say an individual prescribed or taking ampicillin should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take ampicillin.
A person beginning to use ampicillin should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and ampicillin can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and ampicillin may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing ampicillin and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing ampicillin or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent ampicillin from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with ampicillin.
If you take ampicillin, and also drink Alcohol or MDMA, you can research the effects of ampicillin and Alcohol , ampicillin and Cocaine as well as ampicillin and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
ampicillin and Weed
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