amphetamines and Weed
Edited by Hugh Soames
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amphetamines and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including amphetamines. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing amphetamines and Weed.
Mixing amphetamines and Weed
Substituted amphetamines are a class of compounds based upon the amphetamine structure; it includes all derivative compounds which are formed by replacing, or substituting, one or more hydrogen atoms in the amphetamine core structure with substituents. The compounds in this class span a variety of pharmacological subclasses, including stimulants, empathogens, and hallucinogens, among others. Examples of substituted amphetamines are amphetamine (itself), methamphetamine, ephedrine, cathinone, phentermine, mephentermine, tranylcypromine, bupropion, methoxyphenamine, selegiline, amfepramone (diethylpropion), pyrovalerone, MDMA (ecstasy), and DOM (STP).
Some of amphetamine’s substituted derivatives occur in nature, for example in the leaves of Ephedra and khat plants. Amphetamine was first produced at the end of the 19th century. By the 1930s, amphetamine and some of its derivative compounds found use as decongestants in the symptomatic treatment of colds and also occasionally as psychoactive agents. Their effects on the central nervous system are diverse, but can be summarized by three overlapping types of activity: psychoanaleptic, hallucinogenic and empathogenic. Various substituted amphetamines may cause these actions either separately or in combination.
A variety of prodrugs of amphetamine and/or methamphetamine exist, and include amfecloral, amphetaminil, benzphetamine, clobenzorex, D-deprenyl, dimethylamphetamine, ethylamphetamine, fencamine, fenethylline, fenproporex, furfenorex, lisdexamfetamine, mefenorex, prenylamine, and selegiline.
Amphetamines are a subgroup of the substituted phenethylamine class of compounds. Substitution of hydrogen atoms results in a large class of compounds. Typical reaction is substitution by methyl and sometimes ethyl groups at the amine and phenyl sites:
Ephedra was used 5000 years ago in China as a medicinal plant; its active ingredients are alkaloids ephedrine, pseudoephedrine, norephedrine (phenylpropanolamine) and norpseudoephedrine (cathine). Natives of Yemen and Ethiopia have a long tradition of chewing khat leaves to achieve a stimulating effect. The active substances of khat are cathinone and, to a lesser extent, cathine.
Amphetamine was first synthesized in 1887 by Romanian chemist Lazăr Edeleanu, although its pharmacological effects remained unknown until the 1930s. MDMA was produced in 1912 (in 1914, according to other sources) as an intermediate product. However, this synthesis also went largely unnoticed. In the 1920s, both methamphetamine and the dextrorotatory optical isomer of amphetamine, dextroamphetamine, were synthesized. This synthesis was a by-product of a search for ephedrine, a bronchodilator used to treat asthma extracted exclusively from natural sources. Over-the-counter use of substituted amphetamines was initiated in the early 1930s by the pharmaceutical company Smith, Kline & French (now part of GlaxoSmithKline), as a medicine (Benzedrine) for colds and nasal congestion. Subsequently, amphetamine was used in the treatment of narcolepsy, obesity, hay fever, orthostatic hypotension, epilepsy, Parkinson’s disease, alcoholism and migraine. The “reinforcing” effects of substituted amphetamines were quickly discovered, and the misuse of substituted amphetamines had been noted as far back as 1936.
During World War II, amphetamines were used by the German military to keep their tank crews awake for long periods, and treat depression. It was noticed that extended rest was required after such artificially induced activity. The widespread use of substituted amphetamines began in postwar Japan and quickly spread to other countries. Modified “designer amphetamines”, such as MDA and PMA, have gained in popularity since the 1960s. In 1970, the United States adopted “the Controlled Substances Act” that limited non-medical use of substituted amphetamines. Street use of PMA was noted in 1972. MDMA emerged as a substitute for MDA in the early 1970s. American chemist Alexander Shulgin first synthesized the drug in 1976 and through him the drug was briefly introduced into psychotherapy. Recreational use grew and in 1985 MDMA was banned by the US authorities in an emergency scheduling initiated by the Drug Enforcement Administration.
Since the mid-1990s, MDMA has become a popular entactogenic drug among the youth and quite often non-MDMA substances were sold as ecstasy. Ongoing trials are investigating its efficacy as an adjunct to psychotherapy in the management of treatment-resistant post-traumatic stress disorder (PTSD).
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between amphetamines and Weed and an increase in anxiety.
Anyone mixing amphetamines and weed is likely to experience side effects. This happens with all medications whether weed or amphetamines is mixed with them. Side effects can be harmful when mixing amphetamines and weed. Doctors are likely to refuse a patient a amphetamines prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of amphetamines and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including amphetamines are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of amphetamines. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, amphetamines and Weed, dol not interact is wrong. There will always be an interaction between amphetamines and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing amphetamines and Weed is Scromiting. This condition, reportedly caused by mixing amphetamines and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing amphetamines and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and amphetamines and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of amphetamines?
The way in which the body absorbs and process amphetamines may be affected by weed. Therefore, the potency of the amphetamines may be less effective. Marijuana inhibits the metabolization of amphetamines. Not having the right potency of amphetamines means a person may either have a delay in the relief of their underlying symptoms.
A person seeking amphetamines medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right amphetamines medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of amphetamines and Weed
Many individuals may not realize that there are side effects and consequences to mixing amphetamines and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix amphetamines and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing amphetamines and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of amphetamines and Weed is not recommended.
Taking amphetamines and Weed together
People who take amphetamines and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of amphetamines and weed depend on whether you consume more weed in relation to amphetamines or more amphetamines in relation to weed.
The use of significantly more weed and amphetamines will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and amphetamines may experience effects such as:
- reduced motor reflexes from amphetamines and Weed
- dizziness from Weed and amphetamines
- nausea and vomiting due to amphetamines and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and amphetamines leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and amphetamines
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with amphetamines this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and amphetamines affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of amphetamines and weed have a greater adverse effect yet leading medical recommendation is that smaller does of amphetamines can be just as harmful and there is no way of knowing exactly how amphetamines and weed is going to affect an individual before they take it.
Taking amphetamines and weed together
People who take amphetamines and weed together will experience the effects of both substances. The use of significantly more amphetamines with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and amphetamines may experience effects such as:
- reduced motor reflexes from amphetamines and weed
- dizziness from weed and amphetamines
- nausea and vomiting of the amphetamines
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and amphetamines leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs amphetamines
Taking amphetamines in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of amphetamines and weed may have difficulty forming new memories. With weed vs amphetamines in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of amphetamines when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of amphetamines and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
amphetamines Vs Weed
Studies investigating the effects of drugs such as amphetamines and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when amphetamines and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and amphetamines together.
When a small to medium amount of weed is combined with amphetamines, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as amphetamines.
How long after taking amphetamines can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the amphetamines has totally cleared your system before taking weed, even in small quantities.
Overdose on amphetamines and weed
In the case of Overdose on amphetamines or if you are worried after mixing amphetamines and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much amphetamines or mixed weed with amphetamines then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of amphetamines and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing amphetamines and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use amphetamines and weed. These individuals may not realize that there are side effects and consequences to consuming both amphetamines, marijuana and a range of antidepressants.
Studies on weed, amphetamines and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and amphetamines
A lot of people suffer from depression caused by weed and amphetamines. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing amphetamines and weed
Quitting weed to take amphetamines
Medical professionals say an individual prescribed or taking amphetamines should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take amphetamines.
A person beginning to use amphetamines should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and amphetamines can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and amphetamines may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing amphetamines and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing amphetamines or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent amphetamines from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with amphetamines.
If you take amphetamines, and also drink Alcohol or MDMA, you can research the effects of amphetamines and Alcohol , amphetamines and Cocaine as well as amphetamines and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
amphetamines and Weed
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