Adapalene and Alcohol

{Drug} and Alcohol

  1. Authored by Philippa Gold Edited by Hugh Soames Reviewed by Michael Por, MD
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What happens when you mix Adapalene and alcohol


Side effects of mixing alcohol and Adapalene can include


  • Dizziness
  • Sluggishness
  • Drowsiness
  • Shortness of breath
  • Itching
  • Hives
  • Palpitations
  • Respiratory Depression
  • Cardiac Arrest
  • Coma
  • Seizures
  • Death


Interestingly, it is impossible to tell what effect Adapalene and alcohol will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Adapalene and alcohol due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Adapalene and Alcohol it’s imperative that you head to your local emergency room.


Alcohol and Adapalene


Alcohol and Adapalene creates a that has different effects depending on the dose: many people feel stimulated and strengthened at low doses of alcohol and Adapalene and even mixing a small amount of Adapalene and alcohol is not recommended.


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Mixing alcohol and Adapalene


The primary effect of alcohol is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters that are excitatory. When alcohol is combined with Adapalene this primary effect is exaggerated, increasing the strain on the body with unpredictable results.


Alcohol and Adapalene affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Adapalene and alcohol have a greater adverse effect yet leading medic al recommendation is that smaller does can be just as harmful and there is no way of knowing exactly how Adapalene and alcohol is going to affect an individual before they take it.


Taking Adapalene and alcohol together


People who take alcohol and Adapalene together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Adapalene and alcohol depend on whether you consume more alcohol in relation to Adapalene or more Adapalene in relation to alcohol.


The use of significantly more Adapalene with alcohol will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.


People who take both alcohol and Adapalene may experience effects such as:


  • reduced motor reflexes from alcohol and Adapalene
  • dizziness from alcohol and Adapalene
  • nausea and vomiting of the Adapalene


Some people may also experience more euphoria, depression, irritability or all three. A combination of alcohol and Adapalene leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.  Be cautious about continuing on with your daily life as a functioning alcoholic as it can disguise some of the more serious health impacts.

Alcohol Vs Adapalene


Taking Adapalene in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Adapalene and alcohol may have difficulty forming new memories. With alcohol vs Adapalene in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Adapalene when mixed with alcohol it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Adapalene and alcohol can lead to permanent changes in the brain.  Stopping Alcohol Consumption can cause alcohol withdrawals while stopping Adapalene can also cause withdrawals.


Adapalene Vs alcohol


Studies investigating the effects of drugs such as Adapalene and alcohol have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Adapalene and alcohol are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking alcohol and Adapalene together.


When a small to medium amount of alcohol is combined with Adapalene, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much alcohol were associated with other substances such as Adapalene.


Adapalene and alcohol


Adapalene is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne, and is also used off-label to treat keratosis pilaris as well as other skin conditions. Studies have found adapalene is as effective as other retinoids, while causing less irritation. It also has several advantages over other retinoids. The adapalene molecule is more stable compared to tretinoin and tazarotene, which leads to less concern for photodegradation. It is also chemically more stable compared to the other two retinoids, allowing it to be used in combination with benzoyl peroxide. Due to its effects on keratinocyte proliferation and differentiation, adapalene is superior to tretinoin for the treatment of comedonal acne and is often used as a first-line agent. The Swiss company Galderma sells adapalene under the brand-name product Differin.

Per the recommendations of the Global Alliance on Improving Outcomes of Acne, retinoids such as adapalene are considered first-line therapy in acne treatment and are to be used either independently or in conjunction with benzoyl peroxide and/or an antimicrobial agent, like clindamycin, for maximum efficacy. Furthermore, adapalene, like other retinoids, increases the efficacy and penetration of other topical acne medications that are used in conjunction with topical retinoids as well as hastens the improvement of the post-inflammatory hyperpigmentation caused by acne. In the long term, it can be used as maintenance therapy.



How long after taking Adapalene can I drink alcohol


To avoid any residual toxicity it is advisable to wait until the Adapalene has totally cleared your system before drinking alcohol, even in small quantities.


Overdose on Adapalene and alcohol


Overdose on Adapalene and alcohol is alarmingly common and can often be fatal. In the case of Overdose on Adapalene or if you are worried after mixing Adapalene and alcohol call a first responder or proceed to the nearest Emergency Room immediately.


If you are worried about someone who has taken too much Adapalene or mixed alcohol with Adapalene then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Adapalene and alcohol. The combination of alcohol and Adapalene increases the likelihood that a person would be transferred to intensive care.


If you take Adapalene, and also smoke weed or take MDMA, you can research the effects of Adapalene and weed , Adapalene and Cocaine as well as Adapalene and MDMA here.


To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z

Or you could find what you are looking for in our Alcohol and Other Drugs index A to L or Alcohol and Other Drugs index M to Z or our MDMA and Other Drugs Index A to L or MDMA and Other Drugs Index M to Z. or Cocaine and Other Drugs index A to L or Cocaine and Other Drugs index M to Z

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If you are drinking too much alcohol it may be worth understanding if you are suffering from alcoholism.  If you are please consider reaching out for help.


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Adapalene and Alcohol

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