acetazolamide and Cocaine

Cocaine’s, full name is , methyl (1R,2R,3S,5S)-3- (benzoyloxy)-8-methyl-8-azabicyclo[3.2.1] octane-2-carboxylate . It’s a bit of a mouthful so most people just call it by a series of slang names, Snow, powder, line, icing, Blanca, flake, pearl and all the other street names that can leave the uninitiated user a bit confused.

Before we go on to talk about acetazolamide and Cocaine, a disclaimer: The World’s Best Rehab Recovery Blog aims to improve the quality of life for people struggling with addiction and mental health concerns. We use fact-based content and publish material that is researched, cited, edited and reviewed by professionals. The information we publish is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.

Honestly, we don’t recommend mixing acetazolamide with Cocaine.  acetazolamide does nothing to enhance the effects of Cocaine and can cause serious complications that are really going to put a downer on your evening. Like death for example, which is always a risk when using Cocaine or mixing Cocaine and acetazolamide.

There were 19440 deaths in the US in 2020 caused by cocaine alone.  There are serious dangers with the drug, and more when considering mixing it with any other drug.

When mixed with acetazolamide, Cocaine can affect the body’s ability to keep the correct temperature and heart function. Indeed, this can also be caused by taking Cocaine in higher quantities without mixing it with acetazolamide. Users sometimes experience dangerous heart rate and function alterations, which can result in liver, kidney, or heart failure—or even (as we said before) death.

Even taking Cocaine without acetazolamide has a negative effect on the heart, and then taking acetazolamide with it increases the risk exponentially. While common, combining cocaine and acetazolamide together or even hours apart can be extremely risky because it increases heart rate and blood pressure, further increasing the risk of a heart attack. 

Cocaine and acetazolamide also react inside the liver to form a chemical known as cocaethylene, which is toxic to the heart, liver, and other organs. This can also happen even if cocaine and acetazolamide are used separately for several consecutive days. Mixing cocaine with acetazolamide will cause great harm to your heart, liver and other organs. Cocaine and alcohol are a dangerous combination and will be extremely risky for your blood pressure and heart rate. Taking Cocaine and acetazolamide actually increases the risk of a heart attack. 

Some Cocaine addicts say it’s better to mix Cocaine and acetazolamide as they believe it helps to improve the overall psychoactive experience. This is not entirely true. When mixing Cocaine and acetazolamide the interaction ‘tricks’ the brain into taking increased amounts of either the Cocaine, the acetazolamide or both simultaneously. The brain seemingly develops a greater tolerance for both drugs leading the users to consume more. 

Interestingly, there is only so much dopamine and serotonin in the brain. It is a finite supply and mixing Cocaine and acetazolamide exhausts these feel-good chemicals. Once these chemicals are depleted a user will often take even more of both substances which can only lead to further organ damage, respiratory distress, cardiac arrest and often, death.

Since cocaine is a stimulant, people use another substance such as acetazolamide to help their body adjust after the Cocaine effect starts to wear off. At this stage the body is entering a detox phase and the risks of organ failure and death at this stage are just as great. Mixing acetazolamide with Cocaine to help with a comedown is never recommended.

Polydrug addiction seeks to balance the effects of Cocaine by adding acetazolamide. Unfortunately, it’s very dangerous and increases the risk of a fatal overdose.

The risk associated with mixing acetazolamide and Cocaine causes cocaethylene to enter the bloodstream and harm the person’s health, especially their tissues and organs, causing a euphoric effect as cocaine stimulates the brain.

Regular polydosing of acetazolamide and Cocaine may lead to sudden death, high blood pressure, heart palpitations, respiratory failure, damage to brain tissue, ulcers, heart attacks, fever, strokes, cerebral haemorrhages, which causes aneurysms and liver damage. Polydrug addiction combining acetazolamide and Cocaine can also have psychological consequences, such as mental health. 

Adverse effects of mixing acetazolamide and Cocaine will require immediate medical attention. Procedures may include intubation to facilitate breathing, gastric aspiration to remove materials from the stomach, intravenous fluids to hydrate and restore normal body temperature, and to prevent further complications. 

The National Institute and the American Substance Abuse Centers recommend that detoxification and subsequent addiction treatment for dual diagnosis of cocaine and acetazolamide be supervised by a physician in a professional facility to help manage withdrawal symptoms and prevent relapse.

If you’re searching out the interactions between acetazolamide and Cocaine do remember that with Cocaine there’s actually no way to tell what it’s cut and mixed with.  Pure Cocaine—meaning there are no other substances in it—is not a safe drug to take. Cocaine on its own and even without acetazolamide can have many of the same effects as other stimulants like cocaine and amphetamines. A person using Cocaine could experience increased heart rate and blood pressure, muscle tension, involuntary teeth clenching, nausea, blurred vision, faintness, and chills or sweating.

Cocaine is just as likely to be mixed with other substances as any other drug. Supposedly “pure” Cocaine can contain ephedrine (a stimulant), dextromethorphan (a cough suppressant), ketamine, caffeine, cocaine, methamphetamine, or even bath salts. Just because it comes in crystal or powder form—doesn’t prove that it’s pure. With this being the case, there’s no way to accurately predict the effect of mixing acetazolamide and Cocaine in your body. Indeed, the chemical reactions of Cocaine and acetazolamide in your body could be totally different to someone else taking the exact same amount of acetazolamide and Cocaine because of individual physiology.

According to the National Institute on Drug Abuse (NIDA), a substantial percentage of cocaine samples contain some level of adulterants in them. So then, it’s not just looking at the effects of mixing acetazolamide and Cocaine. It’s about mixing Cocaine and acetazolamide and whatever else gets used as a cutting agent.

•  Paramethoxyamphetamine (PMA) or MDEA
•  Aspirin
•  Caffeine
•  Methamphetamine or amphetamine
•  MDMA
•  Bath salts, including drugs like mephedrone
•  Butylone
•  Ketamine
•  LSD

Worryingly, the DEA has also reported that “more than 80 different unique substances have been marketed as Cocaine. Many drugs sold as cocaine contain no Cocaine at all.” Which is a worry, anyway you choose to look at it.

What the above list of cutting agents doesn’t reveal is probably the most harrowing thing to emerge over the past few years. Being the widespread and unreserved use of Fentanyl as a cutting agent for Cocaine and other drugs. Now, Cocaine is used recreationally by many people. It’s illegal. And most people are informed enough to balance the risk (both of prosecution and to health) of taking Cocaine and mixing Cocaine with acetazolamide.

What most people don’t bargain on is getting a massive, deadly dose of Fentanyl thinking it’s Cocaine. Totally wrong. Unacceptable behavior in the eyes of many, yet seemingly acceptable practice by those involved in the sale and production of Cocaine. When we throw Fentanyl into the mix with Cocaine and then {Fuldrug} the chances of a massive Myocardial infarction… AKA heart attack increases dramatically.  

Cocaine is responsible for literally hundreds and thousands of deaths around the World, in people from all walks of life. No drug is ‘safe’. That’s the nature of drugs! If they can be avoided 100% then great. If not. Make yourself aware of all the facts and interactions between drugs. Mixing drugs is not something to take lightly, if you are taking acetazolamide and are also consuming alcohol, MDMA or weed, you can research the effects here.  The effects of acetazolamide and Weed or the effects of acetazolamide and Alcohol, acetazolamide and MDMA.

According to the most recent data, about 119 000 people are treated for problems related to Cocaine in emergency rooms in the United States alone. Furthermore, one study found that in 2020, there were 19,458 deaths from Cocaine.

But the answer to the question, “Can you overdose on cocaine?” the answer is yes but it is not entirely straightforward. While it is possible to die as a result of cocaine use, deaths from this drug are a direct result of taking too much, as well as the side effects. And when mixing acetazolamide and Cocaine these side effects may be enhanced rapidly and exponentially.

According to medical experts, direct deaths from Cocaine use are usually down to heart attacks. Cocaine interferes with the body’s ability to regulate heart function and acetazolamide interferes with this process even further. people are at increased risk of:

• Dehydration
• Heart racing or slowing
• Cardiac failure
• Swelling of the brain
• Muscle breakdown
• Electrolyte imbalances
• Organ failure

Many cocaine “overdoses” are a direct result of additives in the pills themselves, such as Fentanly which we discussed earlier. When Cocaine users arrive at a hospital or rehab center physicians and staff will not immediately know what per cent of the drug they’ve ingested was Cocaine as opposed to other additives, or indeed what other substances (legal or illegal) have been ingested i.e. acetazolamide and Cocaine. This requires blood toxicology examinations and while the results are being waited on, medical professionals will do their best to treat immediate issues such as heart failure or seizures  ¹https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931692/.

Once a patient is stabilized, there is a good chance of a full recovery. That being said, cases of cocaine overdoes can be fatal, especially when Fentanyl and other highly dangerous cutting agents have been used.

If you have been using Cocaine and find that it is difficult to stop, it is likely time to reach out for assistance. Don’t risk an overdose emergency or developing a chronic addiction.

If you take acetazolamide, and also drink alcohol, smoke weed or take MDMA, you can research the effects of acetazolamide and Alcohol as well as acetazolamide and weed and acetazolamide and MDMA

If you also take Cocaine and other drugs you can find information about that on our Cocaine and Other Drugs index A to L or our Cocaine and Other Drugs index M to Z . 

Or you could find what you are looking for in our Alcohol and Other Drugs index A to L or Alcohol and Other Drugs index M to Z or our MDMA and Other Drugs Index A to L or MDMA and Other Drugs Index M to Z.   our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.

To find information on Drug rehab and addiction treatment all over the world

https://www.worldsbest.rehab

If you are looking to stop using either Cocaine or acetazolamide, you may experience withdrawal symptoms.  Cocaine withdrawal can be researched here and acetazolamide withdrawal can be found on our Withdrawal index.

Find the best rehabs near you to help you with curing or controlling your addiction

www.worldsbest.rehab

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