Pitavastatin and Weed

{Fulldrug} and Weed

Authored by Pin Ng PhD

Edited by Hugh Soames

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Pitavastatin and Weed

 

Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Pitavastatin. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Pitavastatin and Weed.

 

Mixing Pitavastatin and Weed

 

Pitavastatin (usually as a calcium salt) is a member of the blood cholesterol lowering medication class of statins.

Like other statins, it is an inhibitor of HMG-CoA reductase, the enzyme that catalyses the first step of cholesterol synthesis.

It was patented in 1987 and approved for medical use in 2003. It is available in Japan, South Korea and in India. In the US, it received FDA approval in 2009.
Kowa Pharmaceuticals, a subsidiary of Kowa Company, is the owner of the American patent to pitavastatin.

Like the other statins, pitavastatin is indicated for hypercholesterolaemia (elevated cholesterol) and for the prevention of cardiovascular disease.

A 2009 study of the 104-week LIVES trial found pitavastatin increased HDL cholesterol, especially in patients with HDL lower than 40 mg/dL, who had a 24.6% rise, in addition to greatly reducing LDL cholesterol 31.3%. HDL improved in patients who switched from other statins and rose over time. In the 70-month CIRCLE observational study, pitavastatin increased HDL more than atorvastatin.

It has neutral or possibly beneficial effects on glucose control. As a consequence, pitavastatin is likely to be appropriate for patients with metabolic syndrome plus high LDL, low HDL and diabetes mellitus.

Common statin-related side effects (headaches, stomach upset, abnormal liver function tests and muscle cramps) were similar to other statins. Pitavastatin is a lipophillic statin. Reports indicate that this statin may lead to fewer muscle side effects than other statins. One study found that coenzyme Q10 was not reduced as much as with certain other statins (though this is unlikely given the inherent chemistry of the HMG-CoA reductase pathway that all statin drugs inhibit).

As opposed to other statins, there is evidence that pitavastatin improves insulin resistance in humans, with insulin resistance assessed by the homeostatic model assessment (HOMA-IR) method.

Hyperuricemia or increased levels of serum uric acid have been reported with pitavastatin.

Most statins are metabolised in part by one or more hepatic cytochrome P450 enzymes, leading to an increased potential for drug interactions and problems with certain foods (such as grapefruit juice). The primary metabolism pathway of pitavastatin is glucuronidation. It is minimally metabolized by the CYP450 enzymes CYP2C9 and CYP2C8, but not by CYP3A4 (which is a common source of interactions in other statins). As a result, it is less likely to interact with drugs that are metabolized via CYP3A4, which might be important for elderly patients who need to take multiple medicines.

Pitavastatin (previously known as itavastatin, itabavastin, nisvastatin, NK-104 or NKS-104) was discovered in Japan by Nissan Chemical Industries and developed further by Kowa Pharmaceuticals, Tokyo. Pitavastatin was approved for use in the United States by the FDA on 08/03/2009 under the trade name Livalo. Pitavastatin has been also approved by the Medicines and Healthcare products Regulatory Agency (MHRA) in UK on 17 August 2010. Zypitamag (pitavastatin magnesium), a pharmaceutical alternative to Livalo, was approved for use in the United States by the FDA in 2017.

The drug is marketed in the United States under the trade names Livalo and Zypitamag, and in the European Union and Russia under the trade name Livazo.

 

Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Pitavastatin and Weed and an increase in anxiety.

 

Anyone mixing Pitavastatin and weed is likely to experience side effects. This happens with all medications whether weed or Pitavastatin is mixed with them. Side effects can be harmful when mixing Pitavastatin and weed. Doctors are likely to refuse a patient a Pitavastatin prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Pitavastatin and Weed.

 

Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Pitavastatin are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Pitavastatin. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Pitavastatin and Weed, dol not interact is wrong. There will always be an interaction between Pitavastatin and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.

 

One of the milder side effects of mixing Pitavastatin and Weed is Scromiting. This condition, reportedly caused by mixing Pitavastatin and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Pitavastatin and Weed is cannabinoid hyperemesis syndrome, or CHS.  For these reasons, some people choose to quit smoking weed.

 

It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.

 

In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Pitavastatin and weed can cause health issues the more a person consumes it.

 

How does Weed effect the potency of Pitavastatin?

 

The way in which the body absorbs and process Pitavastatin may be affected by weed. Therefore, the potency of the Pitavastatin may be less effective. Marijuana inhibits the metabolization of Pitavastatin. Not having the right potency of Pitavastatin means a person may either have a delay in the relief of their underlying symptoms.

 

A person seeking Pitavastatin medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Pitavastatin medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.

 

Sideffects of Pitavastatin and Weed

 

Many individuals may not realize that there are side effects and consequences to mixing Pitavastatin and Weed such as:

 

  • Dizziness
  • Sluggishness
  • Drowsiness
  • Shortness of breath
  • Itching
  • Hives
  • Palpitations
  • Respiratory Depression
  • Cardiac Arrest
  • Coma
  • Seizures
  • Death

 

Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Pitavastatin and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Pitavastatin and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Pitavastatin and Weed is not recommended.

 

Taking Pitavastatin and Weed together

 

People who take Pitavastatin and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Pitavastatin and weed depend on whether you consume more weed in relation to Pitavastatin or more Pitavastatin in relation to weed.

 

The use of significantly more weed and Pitavastatin will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.

 

People who take both weed and Pitavastatin may experience effects such as:

 

  • reduced motor reflexes from Pitavastatin and Weed
  • dizziness from Weed and Pitavastatin
  • nausea and vomiting due to Pitavastatin and Weed

 

Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Pitavastatin leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.

Mixing weed and Pitavastatin

 

The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Pitavastatin this primary effect is exaggerated, increasing the strain on the body with unpredictable results.

 

Weed and Pitavastatin affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Pitavastatin and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Pitavastatin can be just as harmful and there is no way of knowing exactly how Pitavastatin and weed is going to affect an individual before they take it.

 

Taking Pitavastatin and weed together

 

People who take Pitavastatin and weed together will experience the effects of both substances. The use of significantly more Pitavastatin with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.

 

People who take both weed and Pitavastatin may experience effects such as:

 

  • reduced motor reflexes from Pitavastatin and weed
  • dizziness from weed and Pitavastatin
  • nausea and vomiting of the Pitavastatin

 

Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Pitavastatin leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.

Weed Vs Pitavastatin

 

Taking Pitavastatin in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Pitavastatin and weed may have difficulty forming new memories. With weed vs Pitavastatin in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Pitavastatin when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Pitavastatin and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.

 

Pitavastatin Vs Weed

 

Studies investigating the effects of drugs such as Pitavastatin and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Pitavastatin and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Pitavastatin together.

 

When a small to medium amount of weed is combined with Pitavastatin, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Pitavastatin.

 

How long after taking Pitavastatin can I smoke weed or take edibles?

 

To avoid any residual toxicity it is advisable to wait until the Pitavastatin has totally cleared your system before taking weed, even in small quantities.

 

Overdose on Pitavastatin and weed

 

In the case of Overdose on Pitavastatin or if you are worried after mixing Pitavastatin and weed, call a first responder or proceed to the nearest Emergency Room immediately.

 

If you are worried about someone who has taken too much Pitavastatin or mixed weed with Pitavastatin then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Pitavastatin and weed in their system.

 

Excessive Weed intake and result in scromiting, chs, and anxiety disorder.  It is advisable to quit vaping weed if you are feeling these symptoms.

Mixing Pitavastatin and weed and antidepressants

 

Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Pitavastatin and weed. These individuals may not realize that there are side effects and consequences to consuming both Pitavastatin, marijuana and a range of antidepressants.

 

Studies on weed, Pitavastatin and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.

 

Self-medicating with Weed and Pitavastatin

 

A lot of people suffer from depression caused by weed and Pitavastatin. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.

 

Potential side effects from mixing Pitavastatin and weed

 

Quitting weed to take Pitavastatin

 

Medical professionals say an individual prescribed or taking Pitavastatin should not stop using weed cold turkey.  Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Pitavastatin.

 

A person beginning to use Pitavastatin should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.

 

Weed and Pitavastatin can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Pitavastatin may include:

 

  • loss of motor skills
  • poor or lack of coordination
  • lowered blood pressure
  • short-term memory loss
  • increased heart rate
  • increased blood pressure
  • anxiety
  • paranoia
  • increased energy
  • increased motivation

 

Mixing Pitavastatin and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Pitavastatin or other mental health drugs with weed can cause even more unwanted side effects.

 

Mixing drugs and weed conclusion

 

Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Pitavastatin from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Pitavastatin.

 

If you take Pitavastatin, and also drink Alcohol or MDMA, you can research the effects of Pitavastatin and Alcohol , Pitavastatin and Cocaine as well as Pitavastatin and MDMA here.

 

To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.

Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.

 

Pitavastatin and Weed

Pitavastatin and Weed

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  • 1
    1.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/
  • 2
    2.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/
  • 3
    3.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/