Permax and Weed
Edited by Hugh Soames
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Permax and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Permax. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Permax and Weed.
Mixing Permax and Weed
Pergolide, sold under the brand name Permax and Prascend (veterinary) among others, is an ergoline-based dopamine receptor agonist used in some countries for the treatment of Parkinson’s disease. Parkinson’s disease is associated with reduced dopamine activity in the substantia nigra of the brain. Pergolide acts on many of the same receptors as dopamine to increase receptor activity.
It was patented in 1978 and approved for medical use in 1989. In 2007, pergolide was withdrawn from the U.S. market for human use after several published studies revealed a link between the drug and increased rates of valvular heart disease. However, a veterinary form of pergolide, marketed under the trade name Prascend, is permitted for the treatment of pituitary pars intermedia dysfunction (PPID) also known as equine Cushing’s syndrome (ECS) in horses.
Pergolide is not available for use by humans in the United States, however, it is still used in various other countries, where it is used to treat various conditions including Parkinson’s disease, hyperprolactinemia, and restless leg syndrome.
Pergolide is available for veterinary use. Under the trade name Prascend, manufactured by Boehringer Ingelheim, it is commonly used for the treatment of pituitary hyperplasia at the pars intermedia or Equine Cushing’s Syndrome (ECS) in horses.
Pergolide acts as an agonist of dopamine D2 and D1 and serotonin 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT2C receptors. It may possess agonist activity at other dopamine receptor subtypes as well, similar to cabergoline. Although pergolide is more potent as an agonist of the D2 receptor, it has high D1 receptor affinity and is one of the most potent D1 receptor agonists of the dopamine receptor agonists that are clinically available. The agonist activity of pergolide at the D1 receptor somewhat alters its clinical and side effect profile in the treatment of Parkinson’s disease. Pergolide is said to be hallucinogenic due to activation of 5-HT2A receptors. It has been associated with cardiac valvulopathy due to activation of 5-HT2B receptors.
The drug is in decreasing use, as it was reported in 2003 to be associated with a form of heart disease called cardiac fibrosis. In 2007, The United States Food and Drug Administration announced a voluntary withdrawal of the drug by manufacturers due to the possibility of heart valve damage. Pergolide is not currently available in the United States for human use. This problem is thought to be due to pergolide’s action at the 5-HT2B serotonin receptors of cardiac myocytes, causing proliferative valve disease by the same mechanism as ergotamine, methysergide, fenfluramine, and other serotonin 5-HT2B agonists, including serotonin itself when elevated in the blood in carcinoid syndrome. Pergolide can rarely cause Raynaud’s phenomenon. Among similar antiparkinsonian drugs, cabergoline but not lisuride exhibit this same type of serotonin receptor binding. In January, 2007, cabergoline (Dostinex) was reported also to be associated with valvular proliferation heart damage. In March 2007, pergolide was withdrawn from the U.S. market for human use, due to serious valvular damage that was shown in two independent studies.
Pergolide has also been shown to impair associative learning.
At least one British pergolide user has attracted some media attention with claims that it has caused him to develop a gambling addiction. In June 2010, it was reported that more than 100 Australian users of the drug are suing the manufacturer over both gambling and sex addiction problems they claim are the result of the drug’s side effects.
Brand names of pergolide include Permax and Prascend (veterinary), among others.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Permax and Weed and an increase in anxiety.
Anyone mixing Permax and weed is likely to experience side effects. This happens with all medications whether weed or Permax is mixed with them. Side effects can be harmful when mixing Permax and weed. Doctors are likely to refuse a patient a Permax prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Permax and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Permax are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Permax. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Permax and Weed, dol not interact is wrong. There will always be an interaction between Permax and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Permax and Weed is Scromiting. This condition, reportedly caused by mixing Permax and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Permax and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Permax and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Permax?
The way in which the body absorbs and process Permax may be affected by weed. Therefore, the potency of the Permax may be less effective. Marijuana inhibits the metabolization of Permax. Not having the right potency of Permax means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Permax medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Permax medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Permax and Weed
Many individuals may not realize that there are side effects and consequences to mixing Permax and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Permax and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Permax and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Permax and Weed is not recommended.
Taking Permax and Weed together
People who take Permax and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Permax and weed depend on whether you consume more weed in relation to Permax or more Permax in relation to weed.
The use of significantly more weed and Permax will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Permax may experience effects such as:
- reduced motor reflexes from Permax and Weed
- dizziness from Weed and Permax
- nausea and vomiting due to Permax and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Permax leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Permax
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Permax this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Permax affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Permax and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Permax can be just as harmful and there is no way of knowing exactly how Permax and weed is going to affect an individual before they take it.
Taking Permax and weed together
People who take Permax and weed together will experience the effects of both substances. The use of significantly more Permax with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Permax may experience effects such as:
- reduced motor reflexes from Permax and weed
- dizziness from weed and Permax
- nausea and vomiting of the Permax
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Permax leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Permax
Taking Permax in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Permax and weed may have difficulty forming new memories. With weed vs Permax in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Permax when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Permax and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Permax Vs Weed
Studies investigating the effects of drugs such as Permax and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Permax and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Permax together.
When a small to medium amount of weed is combined with Permax, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Permax.
How long after taking Permax can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Permax has totally cleared your system before taking weed, even in small quantities.
Overdose on Permax and weed
In the case of Overdose on Permax or if you are worried after mixing Permax and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Permax or mixed weed with Permax then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Permax and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Permax and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Permax and weed. These individuals may not realize that there are side effects and consequences to consuming both Permax, marijuana and a range of antidepressants.
Studies on weed, Permax and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Permax
A lot of people suffer from depression caused by weed and Permax. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Permax and weed
Quitting weed to take Permax
Medical professionals say an individual prescribed or taking Permax should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Permax.
A person beginning to use Permax should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Permax can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Permax may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Permax and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Permax or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Permax from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Permax.
If you take Permax, and also drink Alcohol or MDMA, you can research the effects of Permax and Alcohol , Permax and Cocaine as well as Permax and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Permax and Weed
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