Paliperidone and Weed
Edited by Hugh Soames
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Paliperidone and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Paliperidone. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Paliperidone and Weed.
Mixing Paliperidone and Weed
Paliperidone, sold under the trade name Invega among others, is an atypical antipsychotic. It is mainly used to treat schizophrenia and schizoaffective disorder.
It is marketed by Janssen Pharmaceuticals. An extended release formulation is available that uses the OROS extended release system to allow for once-daily dosing. Paliperidone palmitate is a long-acting injectable formulation of paliperidone palmitoyl ester.
It is on the World Health Organization’s List of Essential Medicines.
It is used for the treatment of schizophrenia and schizoaffective disorder.
Sources:
The British National Formulary recommends a gradual withdrawal when discontinuing antipsychotics to avoid acute withdrawal syndrome or rapid relapse. Symptoms of withdrawal commonly include nausea, vomiting, and loss of appetite. Other symptoms may include restlessness, increased sweating, and trouble sleeping. Less commonly there may be a feeling of the world spinning, numbness, or muscle pains. Symptoms generally resolve after a short period of time.
There is tentative evidence that discontinuation of antipsychotics can result in psychosis. It may also result in reoccurrence of the condition that is being treated. Rarely tardive dyskinesia can occur when the medication is stopped.
In April 2014, it was reported that 21 Japanese people who had received shots of the long-acting injectable paliperidone to date had died, out of 10,700 individuals prescribed the drug.
Paliperidone is the primary active metabolite of the older antipsychotic risperidone. While its specific mechanism of action is unknown, it is believed paliperidone and risperidone act via similar, if not identical, pathways. Its efficacy is believed to result from central dopaminergic and serotonergic antagonism. Food is known to increase the absorption of Invega type ER OROS prolonged-release tablets. Food increased exposure of paliperidone by up to 50-60%, however, half-life was not significantly affected. The effect was probably due to a delay in the transit of the ER OROS formulation in the upper part of the GI channel, resulting in increased absorption.
The half-life is 23 hours.
Risperidone and its metabolite paliperidone are reduced in efficacy by P-glycoprotein inducers such as St John’s wort
Paliperidone (as Invega) was approved by the Food and Drug Administration (FDA) for the treatment of schizophrenia in 2006. Paliperidone was approved by the FDA for the treatment of schizoaffective disorder in 2009. The long-acting injectable form of paliperidone, marketed as Invega Sustenna in U.S. and Xeplion in Europe, was approved by the FDA on July 31, 2009. It is the only available brand in Bangladesh under the brand name “Palimax ER” manufactured & marketed by ACI Pharmaceuticals.
It was initially approved in Europe in 2007 for schizophrenia, the extended release form and use for schizoaffective disorder were approved in Europe in 2010, and extension to use in adolescents older than 15 years old was approved in 2014.
On May 18, 2015, a new formulation of paliperidone palmitate was approved by the FDA under the brand name Invega Trinza. A similar 3 -monthly injection of prolonged release suspension was approved in 2016 by the European Medicines Agency originally under the brand name Paliperidone Janssen, later renamed to Trevicta. On September 1, 2021, a newer formulation of paliperidone palmitate, Invega Hafyera, was approved by the US FDA which is available as an injection every six months.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Paliperidone and Weed and an increase in anxiety.
Anyone mixing Paliperidone and weed is likely to experience side effects. This happens with all medications whether weed or Paliperidone is mixed with them. Side effects can be harmful when mixing Paliperidone and weed. Doctors are likely to refuse a patient a Paliperidone prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Paliperidone and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Paliperidone are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Paliperidone. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Paliperidone and Weed, dol not interact is wrong. There will always be an interaction between Paliperidone and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Paliperidone and Weed is Scromiting. This condition, reportedly caused by mixing Paliperidone and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Paliperidone and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Paliperidone and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Paliperidone?
The way in which the body absorbs and process Paliperidone may be affected by weed. Therefore, the potency of the Paliperidone may be less effective. Marijuana inhibits the metabolization of Paliperidone. Not having the right potency of Paliperidone means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Paliperidone medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Paliperidone medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Paliperidone and Weed
Many individuals may not realize that there are side effects and consequences to mixing Paliperidone and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Paliperidone and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Paliperidone and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Paliperidone and Weed is not recommended.
Taking Paliperidone and Weed together
People who take Paliperidone and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Paliperidone and weed depend on whether you consume more weed in relation to Paliperidone or more Paliperidone in relation to weed.
The use of significantly more weed and Paliperidone will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Paliperidone may experience effects such as:
- reduced motor reflexes from Paliperidone and Weed
- dizziness from Weed and Paliperidone
- nausea and vomiting due to Paliperidone and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Paliperidone leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Paliperidone
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Paliperidone this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Paliperidone affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Paliperidone and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Paliperidone can be just as harmful and there is no way of knowing exactly how Paliperidone and weed is going to affect an individual before they take it.
Taking Paliperidone and weed together
People who take Paliperidone and weed together will experience the effects of both substances. The use of significantly more Paliperidone with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Paliperidone may experience effects such as:
- reduced motor reflexes from Paliperidone and weed
- dizziness from weed and Paliperidone
- nausea and vomiting of the Paliperidone
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Paliperidone leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Paliperidone
Taking Paliperidone in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Paliperidone and weed may have difficulty forming new memories. With weed vs Paliperidone in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Paliperidone when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Paliperidone and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Paliperidone Vs Weed
Studies investigating the effects of drugs such as Paliperidone and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Paliperidone and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Paliperidone together.
When a small to medium amount of weed is combined with Paliperidone, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Paliperidone.
How long after taking Paliperidone can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Paliperidone has totally cleared your system before taking weed, even in small quantities.
Overdose on Paliperidone and weed
In the case of Overdose on Paliperidone or if you are worried after mixing Paliperidone and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Paliperidone or mixed weed with Paliperidone then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Paliperidone and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Paliperidone and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Paliperidone and weed. These individuals may not realize that there are side effects and consequences to consuming both Paliperidone, marijuana and a range of antidepressants.
Studies on weed, Paliperidone and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Paliperidone
A lot of people suffer from depression caused by weed and Paliperidone. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Paliperidone and weed
Quitting weed to take Paliperidone
Medical professionals say an individual prescribed or taking Paliperidone should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Paliperidone.
A person beginning to use Paliperidone should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Paliperidone can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Paliperidone may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Paliperidone and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Paliperidone or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Paliperidone from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Paliperidone.
If you take Paliperidone, and also drink Alcohol or MDMA, you can research the effects of Paliperidone and Alcohol , Paliperidone and Cocaine as well as Paliperidone and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Paliperidone and Weed
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