Oxybutynin Chloride and Weed
Edited by Hugh Soames
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Oxybutynin Chloride and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Oxybutynin Chloride. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Oxybutynin Chloride and Weed.
Mixing Oxybutynin Chloride and Weed
Oxybutynin, sold as under the brand names Ditropan among others, is a medication used to treat overactive bladder. It works similar to tolterodine, Darifenacin, and Solifenacin. While used for bed wetting in children, evidence to support this use is poor. It is taken by mouth or applied to the skin.
Common side effects include dry mouth, constipation, dizziness, trouble sleeping, and urinary tract infections. Serious side effects may include urinary retention and an increased risk of heat stroke. Use in pregnancy appears safe but has not been well studied while use in breastfeeding is of unclear safety. It is an antimuscarinic and works by blocking the effects of acetylcholine on smooth muscle.
Oxybutynin was approved for medical use in the United States in 1975. It is available as a generic medication. In 2020, it was the 97th most commonly prescribed medication in the United States, with more than 7 million prescriptions.
The immediate and slow release versions work equally.
In people with overactive bladder, transdermal oxybutynin decreased the number of incontinence episodes and increased average voided volume. There was no difference between transdermal oxybutynin and extended-release oral tolterodine.
Tentative evidence supports the use of oxybutynin in hyperhidrosis (excessive sweating).
Common adverse effects that are associated with oxybutynin and other anticholinergics include: dry mouth, difficulty in urination, constipation, blurred vision, drowsiness, and dizziness. Anticholinergics have also been known to induce delirium.
Oxybutynin’s tendency to reduce sweating can be dangerous. Reduced sweating increases the risk of heat exhaustion and heat stroke in apparently safe situations where normal sweating keeps others safe and comfortable. Adverse effects of elevated body temperature are more likely for the elderly and for those with health issues, especially multiple sclerosis.
N-Desethyloxybutynin is an active metabolite of oxybutynin that is thought responsible for much of the adverse effects associated with the use of oxybutynin. N-Desethyloxybutynin plasma levels may reach as much as six times that of the parent drug after administration of the immediate-release oral formulation. Alternative dosage forms have been developed in an effort to reduce blood levels of N-desethyloxybutynin and achieve a steadier concentration of oxybutynin than is possible with the immediate release form. The long-acting formulations also allow once-daily administration instead of the twice-daily dosage required with the immediate-release form. The transdermal patch, in addition to the benefits of the extended-release oral formulations, bypasses the first-pass hepatic effect that the oral formulations are subject to. In those with overflow incontinence because of diabetes or neurological diseases like multiple sclerosis or spinal cord trauma, oxybutynin can worsen overflow incontinence since the fundamental problem is that the bladder is not contracting.
A large study linked the development of dementia in those over 65 to the use of oxybutynin, due to its anticholinergic properties.
Oxybutynin chloride is contraindicated in patients with untreated narrow angle glaucoma, and in patients with untreated narrow anterior chamber angles—since anticholinergic drugs may aggravate these conditions. It is also contraindicated in partial or complete obstruction of the gastrointestinal tract, hiatal hernia, gastroesophageal reflux disease, paralytic ileus, intestinal atony of the elderly or debilitated patient, megacolon, toxic megacolon complicating ulcerative colitis, severe colitis, and myasthenia gravis. It is contraindicated in patients with obstructive uropathy and in patients with unstable cardiovascular status in acute hemorrhage. Oxybutynin chloride is contraindicated in patients who have demonstrated hypersensitivity to the product.
Oxybutynin chloride exerts direct antispasmodic effect on smooth muscle and inhibits the muscarinic action of acetylcholine on smooth muscle. It exhibits one-fifth of the anticholinergic activity of atropine on the rabbit detrusor muscle, but four to ten times the antispasmodic activity. No blocking effects occur at skeletal neuromuscular junctions or autonomic ganglia (antinicotinic effects).
Sources say the drug is absorbed within one hour and has an elimination half-life of 2 to 5 hours. There is a wide variation among individuals in the drug’s concentration in blood. This, and its low concentration in urine, suggest that it is eliminated through the liver.
Oxybutynin contains one stereocenter. Commercial formulations are sold as the racemate. The (R)-enantiomer is a more potent anticholinergic than either the racemate or the (S)-enantiomer, which is essentially without anticholinergic activity at doses used in clinical practice. However, (R)-oxybutynin administered alone offers little or no clinical benefit above and beyond the racemic mixture. The other actions (calcium antagonism, local anesthesia) of oxybutynin are not stereospecific. (S)-Oxybutynin has not been clinically tested for its spasmolytic effects, but may be clinically useful for the same indications as the racemate, without the unpleasant anticholinergic side effects.
Oxybutynin is available by mouth in generic formulation and under the brand names Ditropan, Lyrinel XL, Ditrospam, Kentera, and Aquiette, as a transdermal patch under the brand name Oxytrol, and as a topical gel under the brand name Gelnique.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Oxybutynin Chloride and Weed and an increase in anxiety.
Anyone mixing Oxybutynin Chloride and weed is likely to experience side effects. This happens with all medications whether weed or Oxybutynin Chloride is mixed with them. Side effects can be harmful when mixing Oxybutynin Chloride and weed. Doctors are likely to refuse a patient a Oxybutynin Chloride prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Oxybutynin Chloride and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Oxybutynin Chloride are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Oxybutynin Chloride. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Oxybutynin Chloride and Weed, dol not interact is wrong. There will always be an interaction between Oxybutynin Chloride and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Oxybutynin Chloride and Weed is Scromiting. This condition, reportedly caused by mixing Oxybutynin Chloride and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Oxybutynin Chloride and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Oxybutynin Chloride and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Oxybutynin Chloride?
The way in which the body absorbs and process Oxybutynin Chloride may be affected by weed. Therefore, the potency of the Oxybutynin Chloride may be less effective. Marijuana inhibits the metabolization of Oxybutynin Chloride. Not having the right potency of Oxybutynin Chloride means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Oxybutynin Chloride medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Oxybutynin Chloride medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Oxybutynin Chloride and Weed
Many individuals may not realize that there are side effects and consequences to mixing Oxybutynin Chloride and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Oxybutynin Chloride and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Oxybutynin Chloride and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Oxybutynin Chloride and Weed is not recommended.
Taking Oxybutynin Chloride and Weed together
People who take Oxybutynin Chloride and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Oxybutynin Chloride and weed depend on whether you consume more weed in relation to Oxybutynin Chloride or more Oxybutynin Chloride in relation to weed.
The use of significantly more weed and Oxybutynin Chloride will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Oxybutynin Chloride may experience effects such as:
- reduced motor reflexes from Oxybutynin Chloride and Weed
- dizziness from Weed and Oxybutynin Chloride
- nausea and vomiting due to Oxybutynin Chloride and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Oxybutynin Chloride leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Oxybutynin Chloride
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Oxybutynin Chloride this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Oxybutynin Chloride affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Oxybutynin Chloride and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Oxybutynin Chloride can be just as harmful and there is no way of knowing exactly how Oxybutynin Chloride and weed is going to affect an individual before they take it.
Taking Oxybutynin Chloride and weed together
People who take Oxybutynin Chloride and weed together will experience the effects of both substances. The use of significantly more Oxybutynin Chloride with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Oxybutynin Chloride may experience effects such as:
- reduced motor reflexes from Oxybutynin Chloride and weed
- dizziness from weed and Oxybutynin Chloride
- nausea and vomiting of the Oxybutynin Chloride
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Oxybutynin Chloride leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Oxybutynin Chloride
Taking Oxybutynin Chloride in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Oxybutynin Chloride and weed may have difficulty forming new memories. With weed vs Oxybutynin Chloride in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Oxybutynin Chloride when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Oxybutynin Chloride and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Oxybutynin Chloride Vs Weed
Studies investigating the effects of drugs such as Oxybutynin Chloride and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Oxybutynin Chloride and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Oxybutynin Chloride together.
When a small to medium amount of weed is combined with Oxybutynin Chloride, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Oxybutynin Chloride.
How long after taking Oxybutynin Chloride can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Oxybutynin Chloride has totally cleared your system before taking weed, even in small quantities.
Overdose on Oxybutynin Chloride and weed
In the case of Overdose on Oxybutynin Chloride or if you are worried after mixing Oxybutynin Chloride and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Oxybutynin Chloride or mixed weed with Oxybutynin Chloride then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Oxybutynin Chloride and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Oxybutynin Chloride and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Oxybutynin Chloride and weed. These individuals may not realize that there are side effects and consequences to consuming both Oxybutynin Chloride, marijuana and a range of antidepressants.
Studies on weed, Oxybutynin Chloride and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Oxybutynin Chloride
A lot of people suffer from depression caused by weed and Oxybutynin Chloride. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Oxybutynin Chloride and weed
Quitting weed to take Oxybutynin Chloride
Medical professionals say an individual prescribed or taking Oxybutynin Chloride should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Oxybutynin Chloride.
A person beginning to use Oxybutynin Chloride should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Oxybutynin Chloride can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Oxybutynin Chloride may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Oxybutynin Chloride and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Oxybutynin Chloride or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Oxybutynin Chloride from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Oxybutynin Chloride.
If you take Oxybutynin Chloride, and also drink Alcohol or MDMA, you can research the effects of Oxybutynin Chloride and Alcohol , Oxybutynin Chloride and Cocaine as well as Oxybutynin Chloride and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Oxybutynin Chloride and Weed
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