Nortriptyline Hydrochloride and Weed
Edited by Hugh Soames
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Nortriptyline Hydrochloride and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Nortriptyline Hydrochloride. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Nortriptyline Hydrochloride and Weed.
Mixing Nortriptyline Hydrochloride and Weed
Nortriptyline, sold under the brand name Pamelor, among others, is a medication used to treat depression. This medicine is also sometimes used for neuropathic pain, attention deficit hyperactivity disorder (ADHD), smoking cessation and anxiety. As with many antidepressants, its use for young people with depression and other psychiatric disorders may be limited due to increased suicidality in the 18-24 population initiating treatment. Nortriptyline is a less preferred treatment for ADHD and stopping smoking. It is taken by mouth.
Common side effects include dry mouth, constipation, blurry vision, sleepiness, low blood pressure with standing, and weakness. Serious side effects may include seizures, an increased risk of suicide in those less than 25 years of age, urinary retention, glaucoma, mania, and a number of heart issues. Nortriptyline may cause problems if taken during pregnancy. Use during breastfeeding appears to be relatively safe. It is a tricyclic antidepressant (TCA) and is believed to work by altering levels of serotonin and norepinephrine.
Nortriptyline was approved for medical use in the United States in 1964. It is available as a generic medication. In 2020, it was the 155th most commonly prescribed medication in the United States, with more than 3 million prescriptions.
Nortriptyline is used to treat depression. This medication is in capsule or liquid and is taken by the mouth one to four times a day, with or without food. Usually people are started on a low dose and it is gradually increased. A level between 50 and 150 ng/mL of nortriptyline in the blood generally corresponds with an antidepressant effect.
In the United Kingdom, it may also be used for treating nocturnal enuresis, with courses of treatment lasting no more than three months. It is also used off-label for the treatment of panic disorder, irritable bowel syndrome, migraine prophylaxis and chronic pain or neuralgia modification, particularly temporomandibular joint disorder.
Although not approved by the FDA for neuropathic pain, many randomized controlled trials have demonstrated the effectiveness of TCAs for the treatment of this condition in both depressed and non-depressed individuals. In 2010, an evidence-based guideline sponsored by the International Association for the Study of Pain recommended nortriptyline as a first-line medication for neuropathic pain. However, in a 2015 Cochrane systematic review the authors did not recommend nortriptyline as a first-line agent for neuropathic pain.
Nortriptyline has also been used as an off-label treatment for Irritable Bowel Syndrome, or IBS.
Nortriptyline should not be used in the acute recovery phase after myocardial infarction (viz, heart attack). Use of tricyclic antidepressants along with a monoamine oxidase (MAO) inhibitor, linezolid, and IV methylene blue are contraindicated as it can cause an increased risk of developing serotonin syndrome.
Closer monitoring is required for those with a history of cardiovascular disease, stroke, glaucoma, or seizures, as well as in persons with hyperthyroidism or receiving thyroid hormones.
The most common side effects include dry mouth, sedation, constipation, increased appetite, blurred vision and tinnitus. An occasional side effect is a rapid or irregular heartbeat. Alcohol may exacerbate some of its side effects.
The symptoms and the treatment of an overdose are generally the same as for the other TCAs, including anticholinergic effects, serotonin syndrome and adverse cardiac effects. TCAs, particularly nortriptyline, have a relatively narrow therapeutic index, which increase the chance of an overdose (both accidental and intentional). Symptoms of overdose include: irregular heartbeat, seizures, coma, confusion, hallucination, widened pupils, drowsiness, agitation, fever, low body temperature, stiff muscles and vomiting.
Excessive consumption of alcohol in combination with nortriptyline therapy may have a potentiating effect, which may lead to the danger of increased suicidal attempts or overdosage, especially in patients with histories of emotional disturbances or suicidal ideation.
It may interact with the following drugs:
Nortriptyline is a strong norepinephrine reuptake inhibitor and a moderate serotonin reuptake inhibitor. Its pharmacologic profile is as the table shows with (inhibition or antagonism of all sites).
Nortriptyline is an active metabolite of amitriptyline by demethylation in the liver. Chemically, it is a secondary amine dibenzocycloheptene and pharmacologically it is classed as a first-generation antidepressant.
Nortriptyline may also have a sleep-improving effect due to antagonism of the H1 and 5-HT2A receptors. In the short term, however, nortriptyline may disturb sleep due to its activating effect.
In one study, nortriptyline had the highest affinity for the dopamine transporter among the TCAs (KD = 1,140 nM) besides amineptine (a norepinephrine–dopamine reuptake inhibitor), although its affinity for this transporter was still 261- and 63-fold lower than for the norepinephrine and serotonin transporters (KD = 4.37 and 18 nM, respectively).
Nortriptyline is metabolized in the liver by the hepatic enzyme CYP2D6, and genetic variations within the gene coding for this enzyme can affect its metabolism, leading to changes in the concentrations of the drug in the body. Increased concentrations of nortriptyline may increase the risk for side effects, including anticholinergic and nervous system adverse effects, while decreased concentrations may reduce the drug’s efficacy.
Individuals can be categorized into different types of CYP2D6 metabolizers depending on which genetic variations they carry. These metabolizer types include poor, intermediate, extensive, and ultrarapid metabolizers. Most individuals (about 77–92%) are extensive metabolizers, and have “normal” metabolism of nortriptyline. Poor and intermediate metabolizers have reduced metabolism of the drug as compared to extensive metabolizers; patients with these metabolizer types may have an increased probability of experiencing side effects. Ultrarapid metabolizers use nortriptyline much faster than extensive metabolizers; patients with this metabolizer type may have a greater chance of experiencing pharmacological failure.
The Clinical Pharmacogenetics Implementation Consortium recommends avoiding nortriptyline in persons who are CYP2D6 ultrarapid or poor metabolizers, due to the risk of a lack of efficacy and side effects, respectively. A reduction in starting dose is recommended for patients who are CYP2D6 intermediate metabolizers. If use of nortriptyline is warranted, therapeutic drug monitoring is recommended to guide dose adjustments. The Dutch Pharmacogenetics Working Group recommends reducing the dose of nortriptyline in CYP2D6 poor or intermediate metabolizers, and selecting an alternative drug or increasing the dose in ultrarapid metabolizers.
Nortriptyline is a tricyclic compound, specifically a dibenzocycloheptadiene, and possesses three rings fused together with a side chain attached in its chemical structure. Other dibenzocycloheptadiene TCAs include amitriptyline (N-methylnortriptyline), protriptyline, and butriptyline. Nortriptyline is a secondary amine TCA, with its N-methylated parent amitriptyline being a tertiary amine. Other secondary amine TCAs include desipramine and protriptyline. The chemical name of nortriptyline is 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine and its free base form has a chemical formula of C19H21N1 with a molecular weight of 263.384 g/mol. The drug is used commercially mostly as the hydrochloride salt; the free base form is used rarely. The CAS Registry Number of the free base is 72-69-5 and of the hydrochloride is 894-71-3.
Nortriptyline was developed by Geigy. It first appeared in the literature in 1962 and was patented the same year. The drug was first introduced for the treatment of depression in 1963.
Nortriptyline is the English and French generic name of the drug and its INN, BAN, and DCF, while nortriptyline hydrochloride is its USAN, USP, BANM, and JAN. Its generic name in Spanish and Italian and its DCIT are nortriptilina, in German is nortriptylin, and in Latin is nortriptylinum.
Brand names of nortriptyline include Allegron, Aventyl, Noritren, Norpress, Nortrilen, Norventyl, Norzepine, Pamelor, and Sensoval, among many others.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Nortriptyline Hydrochloride and Weed and an increase in anxiety.
Anyone mixing Nortriptyline Hydrochloride and weed is likely to experience side effects. This happens with all medications whether weed or Nortriptyline Hydrochloride is mixed with them. Side effects can be harmful when mixing Nortriptyline Hydrochloride and weed. Doctors are likely to refuse a patient a Nortriptyline Hydrochloride prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Nortriptyline Hydrochloride and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Nortriptyline Hydrochloride are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Nortriptyline Hydrochloride. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Nortriptyline Hydrochloride and Weed, dol not interact is wrong. There will always be an interaction between Nortriptyline Hydrochloride and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Nortriptyline Hydrochloride and Weed is Scromiting. This condition, reportedly caused by mixing Nortriptyline Hydrochloride and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Nortriptyline Hydrochloride and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Nortriptyline Hydrochloride and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Nortriptyline Hydrochloride?
The way in which the body absorbs and process Nortriptyline Hydrochloride may be affected by weed. Therefore, the potency of the Nortriptyline Hydrochloride may be less effective. Marijuana inhibits the metabolization of Nortriptyline Hydrochloride. Not having the right potency of Nortriptyline Hydrochloride means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Nortriptyline Hydrochloride medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Nortriptyline Hydrochloride medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Nortriptyline Hydrochloride and Weed
Many individuals may not realize that there are side effects and consequences to mixing Nortriptyline Hydrochloride and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Nortriptyline Hydrochloride and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Nortriptyline Hydrochloride and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Nortriptyline Hydrochloride and Weed is not recommended.
Taking Nortriptyline Hydrochloride and Weed together
People who take Nortriptyline Hydrochloride and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Nortriptyline Hydrochloride and weed depend on whether you consume more weed in relation to Nortriptyline Hydrochloride or more Nortriptyline Hydrochloride in relation to weed.
The use of significantly more weed and Nortriptyline Hydrochloride will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Nortriptyline Hydrochloride may experience effects such as:
- reduced motor reflexes from Nortriptyline Hydrochloride and Weed
- dizziness from Weed and Nortriptyline Hydrochloride
- nausea and vomiting due to Nortriptyline Hydrochloride and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Nortriptyline Hydrochloride leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Nortriptyline Hydrochloride
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Nortriptyline Hydrochloride this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Nortriptyline Hydrochloride affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Nortriptyline Hydrochloride and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Nortriptyline Hydrochloride can be just as harmful and there is no way of knowing exactly how Nortriptyline Hydrochloride and weed is going to affect an individual before they take it.
Taking Nortriptyline Hydrochloride and weed together
People who take Nortriptyline Hydrochloride and weed together will experience the effects of both substances. The use of significantly more Nortriptyline Hydrochloride with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Nortriptyline Hydrochloride may experience effects such as:
- reduced motor reflexes from Nortriptyline Hydrochloride and weed
- dizziness from weed and Nortriptyline Hydrochloride
- nausea and vomiting of the Nortriptyline Hydrochloride
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Nortriptyline Hydrochloride leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Nortriptyline Hydrochloride
Taking Nortriptyline Hydrochloride in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Nortriptyline Hydrochloride and weed may have difficulty forming new memories. With weed vs Nortriptyline Hydrochloride in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Nortriptyline Hydrochloride when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Nortriptyline Hydrochloride and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Nortriptyline Hydrochloride Vs Weed
Studies investigating the effects of drugs such as Nortriptyline Hydrochloride and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Nortriptyline Hydrochloride and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Nortriptyline Hydrochloride together.
When a small to medium amount of weed is combined with Nortriptyline Hydrochloride, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Nortriptyline Hydrochloride.
How long after taking Nortriptyline Hydrochloride can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Nortriptyline Hydrochloride has totally cleared your system before taking weed, even in small quantities.
Overdose on Nortriptyline Hydrochloride and weed
In the case of Overdose on Nortriptyline Hydrochloride or if you are worried after mixing Nortriptyline Hydrochloride and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Nortriptyline Hydrochloride or mixed weed with Nortriptyline Hydrochloride then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Nortriptyline Hydrochloride and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Nortriptyline Hydrochloride and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Nortriptyline Hydrochloride and weed. These individuals may not realize that there are side effects and consequences to consuming both Nortriptyline Hydrochloride, marijuana and a range of antidepressants.
Studies on weed, Nortriptyline Hydrochloride and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Nortriptyline Hydrochloride
A lot of people suffer from depression caused by weed and Nortriptyline Hydrochloride. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Nortriptyline Hydrochloride and weed
Quitting weed to take Nortriptyline Hydrochloride
Medical professionals say an individual prescribed or taking Nortriptyline Hydrochloride should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Nortriptyline Hydrochloride.
A person beginning to use Nortriptyline Hydrochloride should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Nortriptyline Hydrochloride can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Nortriptyline Hydrochloride may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Nortriptyline Hydrochloride and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Nortriptyline Hydrochloride or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Nortriptyline Hydrochloride from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Nortriptyline Hydrochloride.
If you take Nortriptyline Hydrochloride, and also drink Alcohol or MDMA, you can research the effects of Nortriptyline Hydrochloride and Alcohol , Nortriptyline Hydrochloride and Cocaine as well as Nortriptyline Hydrochloride and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Nortriptyline Hydrochloride and Weed
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