Mylotarg and Weed
Edited by Hugh Soames
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Mylotarg and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Mylotarg. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Mylotarg and Weed.
Mixing Mylotarg and Weed
Gemtuzumab ozogamicin, sold under the brand name Mylotarg, is an antibody-drug conjugate (a drug-linked monoclonal antibody) that is used to treat acute myeloid leukemia.
The most common side effects include infection, febrile neutropenia, decreased appetite, hyperglycemia, mucositis, hypoxia, hemorrhage, increased transaminase, diarrhea, nausea, and hypotension.
In the United States, gemtuzumab ozogamicin is indicated for newly diagnosed CD33-positive acute myeloid leukemia (AML) for adults and children one month and older and for the treatment of relapsed or refractory CD33-positive AML in adults and children two years and older.
Gemtuzumab is a monoclonal antibody to CD33 linked to a cytotoxic agent from the class of calicheamicins (ozogamicin). CD33 is expressed in most leukemic blast cells but also in normal hematopoietic cells, the intensity diminishing with maturation of stem cells.
Gemtuzumab ozogamicin was created in a collaboration between Celltech and Wyeth that began in 1991. The same collaboration later produced inotuzumab ozogamicin. Celltech was acquired by UCB in 2004 and Wyeth was acquired by Pfizer in 2009.
In the United States, it was approved under an accelerated-approval process by the FDA in 2000, for use in patients over the age of 60 with relapsed acute myelogenous leukemia (AML); or those who are not considered candidates for standard chemotherapy.
The accelerated approval was based on the surrogate endpoint of response rate. It was the first antibody-drug conjugate to be approved.
Within the first year after approval, the FDA required a black box warning be added to gemtuzumab packaging. The drug was noted to increase the risk of veno-occlusive disease in the absence of bone marrow transplantation. Later the onset of VOD was shown to occur at increased frequency in gemtuzumab patients even following bone marrow transplantation. The drug was discussed in a 2008 JAMA article, which criticized the inadequacy of postmarketing surveillance of biologic agents.
A randomized Phase III comparative controlled trial (SWOG S0106) was initiated in 2004, by Wyeth in accordance with the FDA accelerated-approval process. The study was stopped on August 20, 2009, prior to completion due to worrisome outcomes. Among the patients evaluated for early toxicity, fatal toxicity rate was significantly higher in the gemtuzumab combination therapy group vs the standard therapy group. Mortality was 5.7% with gemtuzumab and 1.4% without the agent (16/283 = 5.7% vs 4/281 = 1.4%; P = .01).
In June 2010, Pfizer withdrew Mylotarg from the market at the request of the US FDA. However, some other regulatory authorities did not agree with the FDA decision, with Japan’s Pharmaceuticals and Medical Devices Agency stating in 2011 that the “risk-benefit balance of gemtuzumab ozogamicin has not changed from its state at the time of approval”.
In 2017, Pfizer reapplied for US and EU approval, based on a meta-analysis of prior trials and results of the ALFA-0701 clinical trial, an open-label Phase III trial in 280 older people with AML. In September 2017, gemtuzumab ozogamicin was approved again for use in the United States and in the European Union.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Mylotarg and Weed and an increase in anxiety.
Anyone mixing Mylotarg and weed is likely to experience side effects. This happens with all medications whether weed or Mylotarg is mixed with them. Side effects can be harmful when mixing Mylotarg and weed. Doctors are likely to refuse a patient a Mylotarg prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Mylotarg and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Mylotarg are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Mylotarg. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Mylotarg and Weed, dol not interact is wrong. There will always be an interaction between Mylotarg and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Mylotarg and Weed is Scromiting. This condition, reportedly caused by mixing Mylotarg and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Mylotarg and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Mylotarg and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Mylotarg?
The way in which the body absorbs and process Mylotarg may be affected by weed. Therefore, the potency of the Mylotarg may be less effective. Marijuana inhibits the metabolization of Mylotarg. Not having the right potency of Mylotarg means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Mylotarg medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Mylotarg medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Mylotarg and Weed
Many individuals may not realize that there are side effects and consequences to mixing Mylotarg and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Mylotarg and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Mylotarg and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Mylotarg and Weed is not recommended.
Taking Mylotarg and Weed together
People who take Mylotarg and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Mylotarg and weed depend on whether you consume more weed in relation to Mylotarg or more Mylotarg in relation to weed.
The use of significantly more weed and Mylotarg will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Mylotarg may experience effects such as:
- reduced motor reflexes from Mylotarg and Weed
- dizziness from Weed and Mylotarg
- nausea and vomiting due to Mylotarg and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Mylotarg leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Mylotarg
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Mylotarg this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Mylotarg affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Mylotarg and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Mylotarg can be just as harmful and there is no way of knowing exactly how Mylotarg and weed is going to affect an individual before they take it.
Taking Mylotarg and weed together
People who take Mylotarg and weed together will experience the effects of both substances. The use of significantly more Mylotarg with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Mylotarg may experience effects such as:
- reduced motor reflexes from Mylotarg and weed
- dizziness from weed and Mylotarg
- nausea and vomiting of the Mylotarg
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Mylotarg leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Mylotarg
Taking Mylotarg in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Mylotarg and weed may have difficulty forming new memories. With weed vs Mylotarg in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Mylotarg when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Mylotarg and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Mylotarg Vs Weed
Studies investigating the effects of drugs such as Mylotarg and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Mylotarg and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Mylotarg together.
When a small to medium amount of weed is combined with Mylotarg, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Mylotarg.
How long after taking Mylotarg can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Mylotarg has totally cleared your system before taking weed, even in small quantities.
Overdose on Mylotarg and weed
In the case of Overdose on Mylotarg or if you are worried after mixing Mylotarg and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Mylotarg or mixed weed with Mylotarg then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Mylotarg and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Mylotarg and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Mylotarg and weed. These individuals may not realize that there are side effects and consequences to consuming both Mylotarg, marijuana and a range of antidepressants.
Studies on weed, Mylotarg and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Mylotarg
A lot of people suffer from depression caused by weed and Mylotarg. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Mylotarg and weed
Quitting weed to take Mylotarg
Medical professionals say an individual prescribed or taking Mylotarg should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Mylotarg.
A person beginning to use Mylotarg should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Mylotarg can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Mylotarg may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Mylotarg and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Mylotarg or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Mylotarg from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Mylotarg.
If you take Mylotarg, and also drink Alcohol or MDMA, you can research the effects of Mylotarg and Alcohol , Mylotarg and Cocaine as well as Mylotarg and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Mylotarg and Weed
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