Minipress and Weed
Edited by Hugh Soames
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Minipress and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Minipress. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Minipress and Weed.
Mixing Minipress and Weed
Prazosin, sold under the brand name Minipress among others, is a medication used to treat high blood pressure, symptoms of an enlarged prostate, and nightmares related to post-traumatic stress disorder (PTSD). It is an α1 blocker. It is a less preferred treatment of high blood pressure. Other uses may include heart failure and Raynaud syndrome. It is taken by mouth.
Common side effects include dizziness, sleepiness, nausea, and heart palpitations. Serious side effects may include low blood pressure with standing and depression. Prazosin is a non-selective inverse agonist of the α1-adrenergic receptors. It works to decrease blood pressure by dilating blood vessels and helps with an enlarged prostate by relaxing the outflow of the bladder. How it works in PTSD is not entirely clear.
Prazosin was patented in 1965 and came into medical use in 1974. It is available as a generic medication. In 2020, it was the 190th most commonly prescribed medication in the United States, with more than 2 million prescriptions.
Prazosin is active after taken by mouth and has a minimal effect on cardiac function due to its α1-adrenergic receptor selectivity. When prazosin is started, however, heart rate and contractility can increase in order to maintain the pre-treatment blood pressures because the body has reached homeostasis at its abnormally high blood pressure. The blood pressure lowering effect becomes apparent when prazosin is taken for longer periods of time. The heart rate and contractility go back down over time and blood pressure decreases.
The antihypertensive characteristics of prazosin make it a second-line choice for the treatment of high blood pressure.
Prazosin is also useful in treating urinary hesitancy associated with benign prostatic hyperplasia, blocking α1-adrenergic receptors, which control constriction of both the prostate and urethra. Although not a first-line choice for either hypertension or benign prostatic hyperplasia, it is a choice for people who present with both problems concomitantly.
During its use for urinary hesitancy in military veterans in the 1990s, Murray A. Raskind and colleagues discovered that prazosin appeared to be effective in reducing nightmares. Subsequent reviews indicate prazosin is effective in improving sleep quality and treating nightmares related to post-traumatic stress disorder (PTSD).
Prazosin is used off-label in the treatment of insomnia and can produce sedative effects.
The drug is usually recommended for severe stings from the Indian red scorpion.
Common (4–10% frequency) side effects of prazosin include dizziness, headache, drowsiness, lack of energy, weakness, palpitations, and nausea. Less frequent (1–4%) side effects include vomiting, diarrhea, constipation, edema, orthostatic hypotension, dyspnea, syncope, vertigo, depression, nervousness, nasal congestion and rash. A very rare side effect of prazosin is priapism. One phenomenon associated with prazosin is known as the “first dose response”, in which the side effects of the drug – specifically orthostatic hypotension, dizziness, and drowsiness – are especially pronounced in the first dose.
Orthostatic hypotension and syncope are associated with the body’s poor ability to control blood pressure without active α-adrenergic receptors. The nasal congestion is exacerbated by changing body positions, because α1-adrenergic receptors also control nasal vascular blood flow and alpha blockers inhibit this, in the same way that alpha-adrenergic agonists have the opposite effect of being a decongestant.
Prazosin is an α1-blocker that acts as a non-selective inverse agonist at α1-adrenergic receptors, including of the α1A-, α1B-, and α1D-adrenergic receptor subtypes. It binds to these receptors with affinity (Ki) values of 0.13 to 1.0 nM for the α1Α-adrenergic receptor, 0.06 to 0.62 nM for the α1B-adrenergic receptor, and 0.06 to 0.38 nM for the α1D-adrenergic receptor. It has much lower affinity for the α2-adrenergic receptors (Ki = 210–5,012 nM for the α2A-adrenergic receptor, 13–398 nM for the α2B-adrenergic receptor, and 10–200 nM for the α2C-adrenergic receptor). The α1-adrenergic receptors are found in vascular smooth muscle, where they are responsible for the vasoconstrictive action of norepinephrine. They are also found throughout the central nervous system. α1-Adrenergic receptors have additionally been found on immune cells, where catecholamine binding can stimulate and enhance cytokine production.
Prazosin has an onset of action of 30 to 90 minutes, the elimination half-life of prazosin is 2 to 3 hours, and its duration of action is 10 to 24 hours.
Prazosin has been said to be the only selective α1-adrenergic receptor antagonist which has been used in the treatment of insomnia to any significant degree. It is used at doses of 1 to 12 mg for this purpose. The combination of prazosin and the beta blocker timolol may produce greater sedative effects than either of them alone.
Prazosin has been shown to prevent death in animal models of cytokine storm. As a repurposed drug, prazosin is being investigated for the prevention of cytokine storm syndrome and complications of COVID-19 where it is thought to decrease cytokine dysregulation.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Minipress and Weed and an increase in anxiety.
Anyone mixing Minipress and weed is likely to experience side effects. This happens with all medications whether weed or Minipress is mixed with them. Side effects can be harmful when mixing Minipress and weed. Doctors are likely to refuse a patient a Minipress prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Minipress and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Minipress are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Minipress. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Minipress and Weed, dol not interact is wrong. There will always be an interaction between Minipress and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Minipress and Weed is Scromiting. This condition, reportedly caused by mixing Minipress and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Minipress and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Minipress and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Minipress?
The way in which the body absorbs and process Minipress may be affected by weed. Therefore, the potency of the Minipress may be less effective. Marijuana inhibits the metabolization of Minipress. Not having the right potency of Minipress means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Minipress medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Minipress medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Minipress and Weed
Many individuals may not realize that there are side effects and consequences to mixing Minipress and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Minipress and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Minipress and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Minipress and Weed is not recommended.
Taking Minipress and Weed together
People who take Minipress and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Minipress and weed depend on whether you consume more weed in relation to Minipress or more Minipress in relation to weed.
The use of significantly more weed and Minipress will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Minipress may experience effects such as:
- reduced motor reflexes from Minipress and Weed
- dizziness from Weed and Minipress
- nausea and vomiting due to Minipress and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Minipress leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Minipress
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Minipress this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Minipress affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Minipress and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Minipress can be just as harmful and there is no way of knowing exactly how Minipress and weed is going to affect an individual before they take it.
Taking Minipress and weed together
People who take Minipress and weed together will experience the effects of both substances. The use of significantly more Minipress with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Minipress may experience effects such as:
- reduced motor reflexes from Minipress and weed
- dizziness from weed and Minipress
- nausea and vomiting of the Minipress
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Minipress leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Minipress
Taking Minipress in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Minipress and weed may have difficulty forming new memories. With weed vs Minipress in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Minipress when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Minipress and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Minipress Vs Weed
Studies investigating the effects of drugs such as Minipress and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Minipress and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Minipress together.
When a small to medium amount of weed is combined with Minipress, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Minipress.
How long after taking Minipress can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Minipress has totally cleared your system before taking weed, even in small quantities.
Overdose on Minipress and weed
In the case of Overdose on Minipress or if you are worried after mixing Minipress and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Minipress or mixed weed with Minipress then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Minipress and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Minipress and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Minipress and weed. These individuals may not realize that there are side effects and consequences to consuming both Minipress, marijuana and a range of antidepressants.
Studies on weed, Minipress and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Minipress
A lot of people suffer from depression caused by weed and Minipress. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Minipress and weed
Quitting weed to take Minipress
Medical professionals say an individual prescribed or taking Minipress should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Minipress.
A person beginning to use Minipress should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Minipress can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Minipress may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Minipress and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Minipress or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Minipress from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Minipress.
If you take Minipress, and also drink Alcohol or MDMA, you can research the effects of Minipress and Alcohol , Minipress and Cocaine as well as Minipress and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Minipress and Weed
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