Metyrapone and Weed
Edited by Hugh Soames
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Metyrapone and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Metyrapone. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Metyrapone and Weed.
Mixing Metyrapone and Weed
Metyrapone, sold under the brand name Metopirone, is a medication which is used in the diagnosis of adrenal insufficiency and occasionally in the treatment of Cushing’s syndrome (hypercortisolism).
Metyrapone can be used in the diagnosis of adrenal insufficiency. Metyrapone 30 mg/kg, maximum dose 3,000 mg, is administered at midnight usually with a snack. The plasma cortisol and 11-deoxycortisol are measured the next morning between 8:00 and 9:00 am. A plasma cortisol less than 220 nmol/L indicates adequate inhibition of 11β-hydroxylase. In patients with intact Hypothalamo-pituitary-adrenal axis, CRH and ACTH levels rise as a response to the falling cortisol levels. This results in an increase of the steroid precursors in the pathway. Therefore, if 11-deoxycortisol levels do not rise and remain less than 7 µg/dL (202 nmol/L) and adrenocorticotropic hormone (ACTH) rises, then it is highly suggestive of adrenal insufficiency. If neither 11-deoxycortisol nor ACTH rise, it is highly suggestive of an impaired hypothalamic–pituitary–adrenal axis at either the pituitary or hypothalamus.
The metyrapone test may aid in verifying the cause of Cushing’s syndrome. Most patients with pituitary dysfunction and/or pituitary microadenoma will increase ACTH secretion in response to metyrapone, while most ectopic ACTH-producing tumors will not. Pituitary macroadenomas do not always respond to metyrapone.
Metyrapone is used for the medical control of hypercortisolism in Cushing’s syndrome (ACTH dependent or independent). The aim for medical treatment is to achieve pre-operative control of hypercortisolism, or for control of residual disease persisting post-operatively (TSS, adrenalectomy). It is not for long term definitive treatment/cure, only as an adjunct (surgery is the aim for cure in most causes of Cushing’s syndrome). Metyrapone hence acts by inhibiting adrenal steroidogenesis. One side effect is hirsutism (in women) because of the excess androgen precursors created. The other commonly used agent for medical treatment of Cushing’s is ketoconazole (an anti-fungal agent). This does not exhibit the side effect of hirsutism.
Metyrapone blocks cortisol steroidogenesis by acting as a reversible inhibitor of 11β-hydroxylase. This stimulates adrenocorticotropic hormone (ACTH) secretion, which in turn increases plasma 11-deoxycortisol levels.
Analogues of metyrapone include aminoglutethimide, amphenone B, and mitotane.
Metyrapone has been found in early human trials to reduce recollection of emotional memories in normal volunteers. The volunteers showed significant impairment in ability to retrieve memories with negative emotional content while not impairing memories with neutral content. This has significant implication in the study of the process of emotional healing in post traumatic stress disorder.
Due to the permissive action of cortisol on glucagon, partial blockade of cortisol may reduce
the effects of circulating glucagon in chronically increasing blood glucose in metabolic syndrome (syndrome X) and type 2 diabetes.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Metyrapone and Weed and an increase in anxiety.
Anyone mixing Metyrapone and weed is likely to experience side effects. This happens with all medications whether weed or Metyrapone is mixed with them. Side effects can be harmful when mixing Metyrapone and weed. Doctors are likely to refuse a patient a Metyrapone prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Metyrapone and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Metyrapone are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Metyrapone. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Metyrapone and Weed, dol not interact is wrong. There will always be an interaction between Metyrapone and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Metyrapone and Weed is Scromiting. This condition, reportedly caused by mixing Metyrapone and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Metyrapone and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Metyrapone and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Metyrapone?
The way in which the body absorbs and process Metyrapone may be affected by weed. Therefore, the potency of the Metyrapone may be less effective. Marijuana inhibits the metabolization of Metyrapone. Not having the right potency of Metyrapone means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Metyrapone medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Metyrapone medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Metyrapone and Weed
Many individuals may not realize that there are side effects and consequences to mixing Metyrapone and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Metyrapone and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Metyrapone and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Metyrapone and Weed is not recommended.
Taking Metyrapone and Weed together
People who take Metyrapone and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Metyrapone and weed depend on whether you consume more weed in relation to Metyrapone or more Metyrapone in relation to weed.
The use of significantly more weed and Metyrapone will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Metyrapone may experience effects such as:
- reduced motor reflexes from Metyrapone and Weed
- dizziness from Weed and Metyrapone
- nausea and vomiting due to Metyrapone and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Metyrapone leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Metyrapone
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Metyrapone this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Metyrapone affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Metyrapone and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Metyrapone can be just as harmful and there is no way of knowing exactly how Metyrapone and weed is going to affect an individual before they take it.
Taking Metyrapone and weed together
People who take Metyrapone and weed together will experience the effects of both substances. The use of significantly more Metyrapone with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Metyrapone may experience effects such as:
- reduced motor reflexes from Metyrapone and weed
- dizziness from weed and Metyrapone
- nausea and vomiting of the Metyrapone
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Metyrapone leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Metyrapone
Taking Metyrapone in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Metyrapone and weed may have difficulty forming new memories. With weed vs Metyrapone in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Metyrapone when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Metyrapone and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Metyrapone Vs Weed
Studies investigating the effects of drugs such as Metyrapone and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Metyrapone and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Metyrapone together.
When a small to medium amount of weed is combined with Metyrapone, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Metyrapone.
How long after taking Metyrapone can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Metyrapone has totally cleared your system before taking weed, even in small quantities.
Overdose on Metyrapone and weed
In the case of Overdose on Metyrapone or if you are worried after mixing Metyrapone and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Metyrapone or mixed weed with Metyrapone then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Metyrapone and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Metyrapone and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Metyrapone and weed. These individuals may not realize that there are side effects and consequences to consuming both Metyrapone, marijuana and a range of antidepressants.
Studies on weed, Metyrapone and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Metyrapone
A lot of people suffer from depression caused by weed and Metyrapone. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Metyrapone and weed
Quitting weed to take Metyrapone
Medical professionals say an individual prescribed or taking Metyrapone should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Metyrapone.
A person beginning to use Metyrapone should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Metyrapone can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Metyrapone may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Metyrapone and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Metyrapone or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Metyrapone from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Metyrapone.
If you take Metyrapone, and also drink Alcohol or MDMA, you can research the effects of Metyrapone and Alcohol , Metyrapone and Cocaine as well as Metyrapone and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Metyrapone and Weed
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