Metyrapone and Alcohol

{Drug} and Alcohol

  1. Authored by Philippa Gold Edited by Hugh Soames Reviewed by Michael Por, MD
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What happens when you mix Metyrapone and alcohol


Side effects of mixing alcohol and Metyrapone can include


  • Dizziness
  • Sluggishness
  • Drowsiness
  • Shortness of breath
  • Itching
  • Hives
  • Palpitations
  • Respiratory Depression
  • Cardiac Arrest
  • Coma
  • Seizures
  • Death


Interestingly, it is impossible to tell what effect Metyrapone and alcohol will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Metyrapone and alcohol due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Metyrapone and Alcohol it’s imperative that you head to your local emergency room.


Alcohol and Metyrapone


Alcohol and Metyrapone creates a that has different effects depending on the dose: many people feel stimulated and strengthened at low doses of alcohol and Metyrapone and even mixing a small amount of Metyrapone and alcohol is not recommended.


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Mixing alcohol and Metyrapone


The primary effect of alcohol is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters that are excitatory. When alcohol is combined with Metyrapone this primary effect is exaggerated, increasing the strain on the body with unpredictable results.


Alcohol and Metyrapone affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Metyrapone and alcohol have a greater adverse effect yet leading medic al recommendation is that smaller does can be just as harmful and there is no way of knowing exactly how Metyrapone and alcohol is going to affect an individual before they take it.


Taking Metyrapone and alcohol together


People who take alcohol and Metyrapone together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Metyrapone and alcohol depend on whether you consume more alcohol in relation to Metyrapone or more Metyrapone in relation to alcohol.


The use of significantly more Metyrapone with alcohol will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.


People who take both alcohol and Metyrapone may experience effects such as:


  • reduced motor reflexes from alcohol and Metyrapone
  • dizziness from alcohol and Metyrapone
  • nausea and vomiting of the Metyrapone


Some people may also experience more euphoria, depression, irritability or all three. A combination of alcohol and Metyrapone leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.  Be cautious about continuing on with your daily life as a functioning alcoholic as it can disguise some of the more serious health impacts.

Alcohol Vs Metyrapone


Taking Metyrapone in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Metyrapone and alcohol may have difficulty forming new memories. With alcohol vs Metyrapone in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Metyrapone when mixed with alcohol it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Metyrapone and alcohol can lead to permanent changes in the brain.  Stopping Alcohol Consumption can cause alcohol withdrawals while stopping Metyrapone can also cause withdrawals.


Metyrapone Vs alcohol


Studies investigating the effects of drugs such as Metyrapone and alcohol have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Metyrapone and alcohol are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking alcohol and Metyrapone together.


When a small to medium amount of alcohol is combined with Metyrapone, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much alcohol were associated with other substances such as Metyrapone.


Metyrapone and alcohol


Metyrapone, sold under the brand name Metopirone, is a medication which is used in the diagnosis of adrenal insufficiency and occasionally in the treatment of Cushing’s syndrome (hypercortisolism).

Metyrapone can be used in the diagnosis of adrenal insufficiency. Metyrapone 30 mg/kg, maximum dose 3,000 mg, is administered at midnight usually with a snack. The plasma cortisol and 11-deoxycortisol are measured the next morning between 8:00 and 9:00 am. A plasma cortisol less than 220 nmol/L indicates adequate inhibition of 11β-hydroxylase. In patients with intact Hypothalamo-pituitary-adrenal axis, CRH and ACTH levels rise as a response to the falling cortisol levels. This results in an increase of the steroid precursors in the pathway. Therefore, if 11-deoxycortisol levels do not rise and remain less than 7 µg/dL (202 nmol/L) and adrenocorticotropic hormone (ACTH) rises, then it is highly suggestive of adrenal insufficiency. If neither 11-deoxycortisol nor ACTH rise, it is highly suggestive of an impaired hypothalamic–pituitary–adrenal axis at either the pituitary or hypothalamus.



How long after taking Metyrapone can I drink alcohol


To avoid any residual toxicity it is advisable to wait until the Metyrapone has totally cleared your system before drinking alcohol, even in small quantities.


Overdose on Metyrapone and alcohol


Overdose on Metyrapone and alcohol is alarmingly common and can often be fatal. In the case of Overdose on Metyrapone or if you are worried after mixing Metyrapone and alcohol call a first responder or proceed to the nearest Emergency Room immediately.


If you are worried about someone who has taken too much Metyrapone or mixed alcohol with Metyrapone then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Metyrapone and alcohol. The combination of alcohol and Metyrapone increases the likelihood that a person would be transferred to intensive care.


If you take Metyrapone, and also smoke weed or take MDMA, you can research the effects of Metyrapone and weed , Metyrapone and Cocaine as well as Metyrapone and MDMA here.


To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z

Or you could find what you are looking for in our Alcohol and Other Drugs index A to L or Alcohol and Other Drugs index M to Z or our MDMA and Other Drugs Index A to L or MDMA and Other Drugs Index M to Z. or Cocaine and Other Drugs index A to L or Cocaine and Other Drugs index M to Z

To find information on Drug rehab and addiction treatment all over the world

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If you are drinking too much alcohol it may be worth understanding if you are suffering from alcoholism.  If you are please consider reaching out for help.


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Metyrapone and Alcohol

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