Etanercept and Weed
Edited by Hugh Soames
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Etanercept and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Etanercept. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Etanercept and Weed.
Mixing Etanercept and Weed
Etanercept, sold under the brand name Enbrel among others, is a biologic medical product that is used to treat autoimmune diseases by interfering with tumor necrosis factor (TNF), a soluble inflammatory cytokine, by acting as a TNF inhibitor. It has US Food and Drug Administration (FDA) approval to treat rheumatoid arthritis, juvenile idiopathic arthritis and psoriatic arthritis, plaque psoriasis and ankylosing spondylitis. Tumor necrosis factor alpha (TNFα) is the “master regulator” of the inflammatory (immune) response in many organ systems. Autoimmune diseases are caused by an overactive immune response. Etanercept has the potential to treat these diseases by inhibiting TNF-alpha.
Etanercept is a fusion protein produced by recombinant DNA. It fuses the TNF receptor to the constant end of the IgG1 antibody. First, the developers isolated the DNA sequence that codes the human gene for soluble TNF receptor 2, which is a receptor that binds to tumor necrosis factor-alpha. Second, they isolated the DNA sequence that codes the human gene for the Fc end of immunoglobulin G1 (IgG1). Third, they linked the DNA for TNF receptor 2 to the DNA for IgG1 Fc. Finally, they expressed the linked DNA to produce a protein that links the protein for TNF receptor 2 to the protein for IgG1 Fc.
The prototypic fusion protein was first synthesized and shown to be highly active and unusually stable as a modality for blockade of TNF in vivo in the early 1990s by Bruce A. Beutler, an academic researcher then at the University of Texas Southwestern Medical Center at Dallas, and his colleagues.
These investigators also patented the protein, selling all rights to its use to Immunex, a Seattle biotechnology company that was acquired by Amgen in 2002.
It is a large molecule, with a molecular weight of 150 kDa, that binds to TNFα and decreases its role in disorders involving excess inflammation in humans and other animals, including autoimmune diseases such as ankylosing spondylitis, juvenile rheumatoid arthritis, psoriasis, psoriatic arthritis, rheumatoid arthritis, and, potentially, in a variety of other disorders mediated by excess TNFα. It is on the World Health Organization’s List of Essential Medicines.
In the United States, etanercept is indicated for:
In the European Union, etanercept is indicated to treat:
An American physician, Edward Tobinick, has attempted to use etanercept to treat chronic neurological dysfunction after stroke and brain injury and issued U.S. and foreign patents. Writing for Science-Based Medicine, Steven Novella said that it was “unethical for physicians to practice outside of their area of competence and expertise”. Tobinick attempted unsuccessfully to sue Novella in response. Of this treatment, the American Academy of Neurology advise “there is insufficient evidence to determine its effectiveness and that the treatment may be associated with adverse outcomes and high cost”.
On May 2, 2008, the US Food and Drug Administration (FDA) placed a black box warning on etanercept due to a number of serious infections associated with the drug. Serious infections and sepsis, including fatalities, have been reported with the use of etanercept including reactivation of latent tuberculosis and hepatitis B infections.
Etanercept reduces the effect of naturally present TNF, and hence is a TNF inhibitor, functioning as a decoy receptor that binds to TNF.
Tumor necrosis factor-alpha (TNFα) is a cytokine produced by lymphocytes and macrophages, two types of white blood cells. It mediates the immune response by attracting additional white blood cells to sites of inflammation and through additional molecular mechanisms that initiate and amplify inflammation. Inhibition of its action by etanercept reduces the inflammatory response, which is especially useful for treating autoimmune diseases.
There are two types of TNF receptors: those found embedded in white blood cells that respond to TNF by releasing other cytokines, and soluble TNF receptors that are used to deactivate TNF and blunt the immune response. In addition, TNF receptors are found on the surface of virtually all nucleated cells (red blood cells, which are not nucleated, do not contain TNF receptors on their surface). Etanercept mimics the inhibitory effects of naturally occurring soluble TNF receptors, the difference being that etanercept, because it is a fusion protein rather than a simple TNF receptor, has a greatly extended half-life in the bloodstream, and therefore a more profound and long-lasting biologic effect than a naturally occurring soluble TNF receptor.
Etanercept is made from the combination of two naturally occurring soluble human 75-kilodalton TNF receptors linked to an Fc portion of an IgG1. The effect is an artificially engineered dimeric fusion protein. Etanercept is a complex molecule containing 6 N-glycans, up to 14 O-glycans and 29 disulfide bridge structures.
The first etanercept-related patent was filed by Immunex on September 5, 1989. The fusion protein was developed by Bruce A. Beutler, an academic researcher then at the University of Texas Southwestern Medical Center at Dallas, and colleagues, who patented it and licensed the rights in 1995 to Immunex. Another patent on such fusion protein technology from Brian Seed at Massachusetts General Hospital was licensed to Immmunex in 1997.
Etanercept was approved for use in the United States in November 1998.
Etanercept was approved for use in the European Union in February 2000.
The US retail price of etanercept has risen over time. In 2008, the cost of etanercept was $1,500 per month or $18,000 per year. By 2011, the cost had exceeded $20,000 per year. In 2013, a survey by the International Federation of Health Plans (IFHP) found that the average US cost for etanercept was $2,225 per month, or $26,700 per year. The IFHP report also found wide variation in prices charged to various US health plans, between $1,946 per month at the 25th percentile and $4,006 per month at the 95th percentile.
Etanercept is more expensive in the US than in other countries. As of 2013, average monthly costs in surveyed nations ranged from $1,017 in Switzerland to $1,646 in Canada, compared to an average monthly cost of $2,225 per month in the US.
Amgen sells etanercept within the US and Canada, while Pfizer, Inc. sells the drug outside of the US and Canada. Sales within the US and Canada were $3.5 billion in 2010. Sales of etanercept outside the US and Canada were $3.3 billion in 2010.
The patent on etanercept was set to expire on October 23, 2012, but, in the United States, a second patent, granting exclusivity for another 16 years, has been granted.
Before the extension it seemed unlikely that a generic would have been available. As a biologic, etanercept is subject to different laws from those applicable to chemical formulations. Many countries do not permit the manufacture of generic biologics. However, the European Union and the United States (Biologics Price Competition and Innovation Act of 2009) do have in place a system to approve generic biologics (biosimilars) which “requires mandatory clinical testing and periodic review”.
In April 2013, the Indian pharma major Cipla made an announcement about launching the first biosimilar of Etanercept in India under the brand name Etacept for the treatment of rheumatic disorders.
In January 2016, Benepali was approved for use in the European Union.
In February 2017, Lifmior was approved for use in the European Union. It was withdrawn from the market in February 2020.
In June 2017, Erelzi was approved for use in the European Union.
In March 2019, YLB113 (Etanercept biosimilar by YL Biologics) was approved in Japan.
In May 2020, Nepexto was approved for use in the European Union.
Rymti and Etera were approved for medical use in Australia in October 2020.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Etanercept and Weed and an increase in anxiety.
Anyone mixing Etanercept and weed is likely to experience side effects. This happens with all medications whether weed or Etanercept is mixed with them. Side effects can be harmful when mixing Etanercept and weed. Doctors are likely to refuse a patient a Etanercept prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Etanercept and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Etanercept are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Etanercept. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Etanercept and Weed, dol not interact is wrong. There will always be an interaction between Etanercept and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Etanercept and Weed is Scromiting. This condition, reportedly caused by mixing Etanercept and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Etanercept and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Etanercept and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Etanercept?
The way in which the body absorbs and process Etanercept may be affected by weed. Therefore, the potency of the Etanercept may be less effective. Marijuana inhibits the metabolization of Etanercept. Not having the right potency of Etanercept means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Etanercept medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Etanercept medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Etanercept and Weed
Many individuals may not realize that there are side effects and consequences to mixing Etanercept and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Etanercept and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Etanercept and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Etanercept and Weed is not recommended.
Taking Etanercept and Weed together
People who take Etanercept and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Etanercept and weed depend on whether you consume more weed in relation to Etanercept or more Etanercept in relation to weed.
The use of significantly more weed and Etanercept will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Etanercept may experience effects such as:
- reduced motor reflexes from Etanercept and Weed
- dizziness from Weed and Etanercept
- nausea and vomiting due to Etanercept and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Etanercept leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Etanercept
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Etanercept this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Etanercept affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Etanercept and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Etanercept can be just as harmful and there is no way of knowing exactly how Etanercept and weed is going to affect an individual before they take it.
Taking Etanercept and weed together
People who take Etanercept and weed together will experience the effects of both substances. The use of significantly more Etanercept with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Etanercept may experience effects such as:
- reduced motor reflexes from Etanercept and weed
- dizziness from weed and Etanercept
- nausea and vomiting of the Etanercept
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Etanercept leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Etanercept
Taking Etanercept in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Etanercept and weed may have difficulty forming new memories. With weed vs Etanercept in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Etanercept when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Etanercept and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Etanercept Vs Weed
Studies investigating the effects of drugs such as Etanercept and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Etanercept and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Etanercept together.
When a small to medium amount of weed is combined with Etanercept, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Etanercept.
How long after taking Etanercept can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Etanercept has totally cleared your system before taking weed, even in small quantities.
Overdose on Etanercept and weed
In the case of Overdose on Etanercept or if you are worried after mixing Etanercept and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Etanercept or mixed weed with Etanercept then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Etanercept and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Etanercept and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Etanercept and weed. These individuals may not realize that there are side effects and consequences to consuming both Etanercept, marijuana and a range of antidepressants.
Studies on weed, Etanercept and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Etanercept
A lot of people suffer from depression caused by weed and Etanercept. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Etanercept and weed
Quitting weed to take Etanercept
Medical professionals say an individual prescribed or taking Etanercept should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Etanercept.
A person beginning to use Etanercept should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Etanercept can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Etanercept may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Etanercept and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Etanercept or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Etanercept from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Etanercept.
If you take Etanercept, and also drink Alcohol or MDMA, you can research the effects of Etanercept and Alcohol , Etanercept and Cocaine as well as Etanercept and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Etanercept and Weed
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