Cinacalcet and Weed

Edited by Hugh Soames
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Cinacalcet and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Cinacalcet. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Cinacalcet and Weed.
Mixing Cinacalcet and Weed
Cinacalcet, sold under the brand name Sensipar among others, is a medication used to treat tertiary hyperparathyroidism, parathyroid carcinoma, and primary hyperparathyroidism. Cinacalcet acts as a calcimimetic (i.e., it mimics the action of calcium on tissues) by allosteric activation of the calcium-sensing receptor that is expressed in various human organ tissues.
The most common side effects include nausea (feeling sick) and vomiting.
Cinacalcet was approved in the United States in March 2004, and in the European Union in October 2004. It was the first allosteric G protein-coupled receptor modulator to enter the pharmaceutical market. In 2013, cinacalcet was the 76th top prescribed medicine in the United States.
In the United States, cinacalcet is indicated for the treatment of secondary hyperparathyroidism in people with chronic kidney disease on dialysis and hypercalcemia in people with parathyroid carcinoma. Cinacalcet can also be used to treat severe hypercalcemia in patients with primary hyperparathyroidism who are unable to undergo parathyroidectomy.
In the European Union cinacalcet is indicated for:
Cinacalcet has pregnancy category C in the US, meaning that adequate and well-controlled studies involving cinacalcet in pregnant women have not been done.
Studies have not been done in lactating women; therefore it is not known whether cinacalcet is excreted into human milk.
Hypocalcemia (decreased calcium levels) is a contraindication of cinacalcet. Those who have serum calcium levels less than 7.5 mg/dL should not be started on cinacalcet. Hypocalcemia symptoms include parethesias, myalgias, muscle cramping, tetany, and convulsions. Cinacalcet should not be administered until serum calcium levels are above 8.0 mg/dL and/or hypocalcemia symptoms are resolved. Cinacalcet is not approved for pediatric use in the United States.
Common side effects of cinacalcet include stomach upset, vomiting, diarrhea, dizziness, nausea, weakness, and chest pain.
Clinical trials conducted in the United States by Amgen to determine whether the drug is safe in children were halted by the U.S. Food and Drug Administration (FDA) in February 2013, following the death of a 14-year-old participant.
Serious side effects, including overdose symptoms, of cinacalcet include:
Cinacalcet is a strong inhibitor of the liver enzyme CYP2D6 and is partially metabolized by CYP3A4 and CYP1A2. Dose adjustments may be necessary if people are treated with CYP3A4 and CYP1A2 inhibitors and medications that are metabolized by CYP2D6.
Cinacalcet is a drug that acts as a calcimimetic (i.e. it mimics the action of calcium on tissues) by allosteric activation of the calcium-sensing receptor that is expressed in various human organ tissues. The calcium-sensing receptors on the surface of the chief cell of the parathyroid gland is the principal negative regulator of parathyroid hormone secretion. Cinacalcet increases the sensitivity of calcium receptors on parathyroid cells to reduce parathyroid hormone (PTH) levels and thus decrease serum calcium levels.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Cinacalcet and Weed and an increase in anxiety.
Anyone mixing Cinacalcet and weed is likely to experience side effects. This happens with all medications whether weed or Cinacalcet is mixed with them. Side effects can be harmful when mixing Cinacalcet and weed. Doctors are likely to refuse a patient a Cinacalcet prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Cinacalcet and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Cinacalcet are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Cinacalcet. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Cinacalcet and Weed, dol not interact is wrong. There will always be an interaction between Cinacalcet and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Cinacalcet and Weed is Scromiting. This condition, reportedly caused by mixing Cinacalcet and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Cinacalcet and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Cinacalcet and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Cinacalcet?
The way in which the body absorbs and process Cinacalcet may be affected by weed. Therefore, the potency of the Cinacalcet may be less effective. Marijuana inhibits the metabolization of Cinacalcet. Not having the right potency of Cinacalcet means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Cinacalcet medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Cinacalcet medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Cinacalcet and Weed
Many individuals may not realize that there are side effects and consequences to mixing Cinacalcet and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Cinacalcet and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Cinacalcet and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Cinacalcet and Weed is not recommended.
Taking Cinacalcet and Weed together
People who take Cinacalcet and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Cinacalcet and weed depend on whether you consume more weed in relation to Cinacalcet or more Cinacalcet in relation to weed.
The use of significantly more weed and Cinacalcet will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Cinacalcet may experience effects such as:
- reduced motor reflexes from Cinacalcet and Weed
- dizziness from Weed and Cinacalcet
- nausea and vomiting due to Cinacalcet and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Cinacalcet leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Cinacalcet
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Cinacalcet this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Cinacalcet affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Cinacalcet and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Cinacalcet can be just as harmful and there is no way of knowing exactly how Cinacalcet and weed is going to affect an individual before they take it.
Taking Cinacalcet and weed together
People who take Cinacalcet and weed together will experience the effects of both substances. The use of significantly more Cinacalcet with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Cinacalcet may experience effects such as:
- reduced motor reflexes from Cinacalcet and weed
- dizziness from weed and Cinacalcet
- nausea and vomiting of the Cinacalcet
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Cinacalcet leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Cinacalcet
Taking Cinacalcet in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Cinacalcet and weed may have difficulty forming new memories. With weed vs Cinacalcet in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Cinacalcet when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Cinacalcet and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Cinacalcet Vs Weed
Studies investigating the effects of drugs such as Cinacalcet and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Cinacalcet and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Cinacalcet together.
When a small to medium amount of weed is combined with Cinacalcet, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Cinacalcet.
How long after taking Cinacalcet can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Cinacalcet has totally cleared your system before taking weed, even in small quantities.
Overdose on Cinacalcet and weed
In the case of Overdose on Cinacalcet or if you are worried after mixing Cinacalcet and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Cinacalcet or mixed weed with Cinacalcet then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Cinacalcet and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Cinacalcet and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Cinacalcet and weed. These individuals may not realize that there are side effects and consequences to consuming both Cinacalcet, marijuana and a range of antidepressants.
Studies on weed, Cinacalcet and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Cinacalcet
A lot of people suffer from depression caused by weed and Cinacalcet. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Cinacalcet and weed
Quitting weed to take Cinacalcet
Medical professionals say an individual prescribed or taking Cinacalcet should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Cinacalcet.
A person beginning to use Cinacalcet should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Cinacalcet can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Cinacalcet may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Cinacalcet and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Cinacalcet or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Cinacalcet from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Cinacalcet.
If you take Cinacalcet, and also drink Alcohol or MDMA, you can research the effects of Cinacalcet and Alcohol , Cinacalcet and Cocaine as well as Cinacalcet and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.

Cinacalcet and Weed
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