Cidofovir and Weed
Edited by Hugh Soames
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Cidofovir and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Cidofovir. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Cidofovir and Weed.
Mixing Cidofovir and Weed
Cidofovir, brand name Vistide, is a topical or injectable antiviral medication primarily used as a treatment for cytomegalovirus (CMV) retinitis (an infection of the retina of the eye) in people with AIDS.
Cidofovir was approved for medical use in 1996.
Its only indication that has received regulatory approval worldwide is cytomegalovirus retinitis. Cidofovir has also shown efficacy in the treatment of aciclovir-resistant HSV infections. Cidofovir has also been investigated as a treatment for progressive multifocal leukoencephalopathy with successful case reports of its use. Despite this, the drug failed to demonstrate any efficacy in controlled studies. Cidofovir might have anti-smallpox efficacy and might be used on a limited basis in the event of a bioterror incident involving smallpox cases. Brincidofovir, a cidofovir derivative with much higher activity against smallpox that can be taken orally has been developed. It has inhibitory effects on varicella-zoster virus replication in vitro although no clinical trials have been done to date, likely due to the abundance of safer alternatives such as aciclovir. Cidofovir shows anti-BK virus activity in a subgroup of transplant recipients. Cidofovir is being investigated as a complementary intralesional therapy against papillomatosis caused by HPV.
It first received FDA approval on 26 June 1996, TGA approval on 30 April 1998 and EMA approval on 23 April 1997.
It has been used topically to treat warts.
It has been suggested as an antitumour agent, due to its suppression of FGF2.
Cidofovir is only available as an intravenous formulation. Cidofovir is to be administered with probenecid which decreases side effects to the kidney. Probenecid mitigates nephrotoxicity by inhibiting organic anion transport of the proximal tubule epithelial cells of the kidney. In addition, hydration must be administered to patients receiving cidofovir. 1 liter of normal saline is recommended in conjunction with each dose of cidofovir.
The major dose-limiting side effect of cidofovir is nephrotoxicity (i.e., kidney damage). Other common side effects (occurring in >1% of people treated with the drug) include:
Whereas uncommon side effects include: anaemia and elevated liver enzymes and rare side effects include: tachycardia and Fanconi syndrome. Probenecid (a uricosuric drug) and intravenous saline should always be administered with each cidofovir infusion to prevent this nephrotoxicity.
Hypersensitivity to cidofovir or probenecid (as probenecid needs to be given concurrently to avoid nephrotoxicity).
It is known to interact with nephrotoxic agents (e.g. amphotericin B, foscarnet, IV aminoglycosides, IV pentamide, vancomycin, tacrolimus, non-steroid anti-inflammatory drugs, etc.) to increase their nephrotoxic potential. As it must be given concurrently with probenecid it is advised that drugs that are known to interact with probenecid (e.g. drugs that probenecid interferes with the renal tubular secretion of, such as paracetamol, aciclovir, aminosalicylic acid, etc.) are also withheld.
Its active metabolite, cidofovir diphosphate, inhibits viral replication by selectively inhibiting viral DNA polymerases. It also inhibits human polymerases, but this action is 8–600 times weaker than its actions on viral DNA polymerases. It also incorporates itself into viral DNA, hence inhibiting viral DNA synthesis during reproduction.
It possesses in vitro activity against the following viruses:
Cidofovir was discovered at the Institute of Organic Chemistry and Biochemistry, Prague, by Antonín Holý, and developed by Gilead Sciences and is marketed with the brand name Vistide by Gilead in the US, and by Pfizer elsewhere.
Cidofovir can be synthesized from a pyrimidone derivative and a protected derivative of glycidol.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Cidofovir and Weed and an increase in anxiety.
Anyone mixing Cidofovir and weed is likely to experience side effects. This happens with all medications whether weed or Cidofovir is mixed with them. Side effects can be harmful when mixing Cidofovir and weed. Doctors are likely to refuse a patient a Cidofovir prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Cidofovir and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Cidofovir are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Cidofovir. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Cidofovir and Weed, dol not interact is wrong. There will always be an interaction between Cidofovir and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Cidofovir and Weed is Scromiting. This condition, reportedly caused by mixing Cidofovir and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Cidofovir and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Cidofovir and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Cidofovir?
The way in which the body absorbs and process Cidofovir may be affected by weed. Therefore, the potency of the Cidofovir may be less effective. Marijuana inhibits the metabolization of Cidofovir. Not having the right potency of Cidofovir means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Cidofovir medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Cidofovir medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Cidofovir and Weed
Many individuals may not realize that there are side effects and consequences to mixing Cidofovir and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Cidofovir and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Cidofovir and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Cidofovir and Weed is not recommended.
Taking Cidofovir and Weed together
People who take Cidofovir and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Cidofovir and weed depend on whether you consume more weed in relation to Cidofovir or more Cidofovir in relation to weed.
The use of significantly more weed and Cidofovir will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Cidofovir may experience effects such as:
- reduced motor reflexes from Cidofovir and Weed
- dizziness from Weed and Cidofovir
- nausea and vomiting due to Cidofovir and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Cidofovir leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Cidofovir
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Cidofovir this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Cidofovir affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Cidofovir and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Cidofovir can be just as harmful and there is no way of knowing exactly how Cidofovir and weed is going to affect an individual before they take it.
Taking Cidofovir and weed together
People who take Cidofovir and weed together will experience the effects of both substances. The use of significantly more Cidofovir with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Cidofovir may experience effects such as:
- reduced motor reflexes from Cidofovir and weed
- dizziness from weed and Cidofovir
- nausea and vomiting of the Cidofovir
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Cidofovir leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Cidofovir
Taking Cidofovir in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Cidofovir and weed may have difficulty forming new memories. With weed vs Cidofovir in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Cidofovir when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Cidofovir and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Cidofovir Vs Weed
Studies investigating the effects of drugs such as Cidofovir and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Cidofovir and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Cidofovir together.
When a small to medium amount of weed is combined with Cidofovir, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Cidofovir.
How long after taking Cidofovir can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Cidofovir has totally cleared your system before taking weed, even in small quantities.
Overdose on Cidofovir and weed
In the case of Overdose on Cidofovir or if you are worried after mixing Cidofovir and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Cidofovir or mixed weed with Cidofovir then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Cidofovir and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Cidofovir and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Cidofovir and weed. These individuals may not realize that there are side effects and consequences to consuming both Cidofovir, marijuana and a range of antidepressants.
Studies on weed, Cidofovir and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Cidofovir
A lot of people suffer from depression caused by weed and Cidofovir. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Cidofovir and weed
Quitting weed to take Cidofovir
Medical professionals say an individual prescribed or taking Cidofovir should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Cidofovir.
A person beginning to use Cidofovir should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Cidofovir can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Cidofovir may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Cidofovir and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Cidofovir or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Cidofovir from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Cidofovir.
If you take Cidofovir, and also drink Alcohol or MDMA, you can research the effects of Cidofovir and Alcohol , Cidofovir and Cocaine as well as Cidofovir and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Cidofovir and Weed
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