Cholecalciferol and Weed
Edited by Hugh Soames
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Cholecalciferol and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Cholecalciferol. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Cholecalciferol and Weed.
Mixing Cholecalciferol and Weed
Cholecalciferol, also known as vitamin D3 and colecalciferol, is a type of vitamin D that is made by the skin when exposed to sunlight; it is found in some foods and can be taken as a dietary supplement.
Cholecalciferol is made in the skin following UVB light exposure. It is converted in the liver to calcifediol (25-hydroxyvitamin D) which is then converted in the kidney to calcitriol (1,25-dihydroxyvitamin D). One of its actions is to increase calcium uptake by the intestines. It is found in food such as some fish, beef liver, eggs, and cheese. Plants, cow milk, fruit juice, yogurt, and margarine also may have cholecalciferol added to them in some countries, including the United States.
Cholecalciferol can be taken as an oral dietary supplement to prevent vitamin D deficiency or as a medication to treat associated diseases, including rickets. It is also used for familial hypophosphatemia, hypoparathyroidism that is causing low blood calcium, and Fanconi syndrome. Vitamin-D supplements may not be effective in people with severe kidney disease. Excessive doses in humans can result in vomiting, constipation, weakness, and confusion. Other risks include kidney stones. Doses greater than 40,000 IU (1,000 μg) per day are generally required before high blood calcium occurs. Normal doses, 800–2000 IU per day, are safe in pregnancy.
Cholecalciferol was first described in 1936. It is on the World Health Organization’s List of Essential Medicines. In 2020, it was the 60th most commonly prescribed medication in the United States, with more than 11 million prescriptions. Cholecalciferol is available as a generic medication and over the counter.
Cholecalciferol appears to stimulate the body’s interferon type I signaling system that protects against bacteria and viruses, unlike Vitamin D2.
Cholecalciferol is a form of vitamin D which is naturally synthesized in skin and functions as a pro-hormone, being converted to calcitriol. This is important for maintaining calcium levels and promoting bone health and development. As a medication, cholecalciferol may be taken as a dietary supplement to prevent or to treat vitamin D deficiency. One gram is 40,000,000 (40×106) IU, equivalently 1 IU is 0.025 μg or 25 ng. Dietary reference intake values for vitamin D (cholecalciferol and/or ergocalciferol) have been established and recommendations vary depending on the country:
Low levels of vitamin D are more commonly found in individuals living in northern latitudes, or with other reasons for a lack of regular sun exposure, including being housebound, frail, elderly, obese, having darker skin, or wearing clothes that cover most of the skin. Supplements are recommended for these groups of people.
The Institute of Medicine in 2010 recommended a maximum uptake of vitamin D of 4,000 IU/day, finding that the dose for lowest observed adverse effect level is 40,000 IU daily for at least 12 weeks, and that there was a single case of toxicity above 10,000 IU after more than 7 years of daily intake; this case of toxicity occurred in circumstances that have led other researchers to dispute it as a credible case to consider when making vitamin D intake recommendations. Patients with severe vitamin D deficiency will require treatment with a loading dose; its magnitude can be calculated based on the actual serum 25-hydroxy-vitamin D level and body weight.
There are conflicting reports concerning the relative effectiveness of cholecalciferol (D3) versus ergocalciferol (D2), with some studies suggesting less efficacy of D2, and others showing no difference. There are differences in absorption, binding and inactivation of the two forms, with evidence usually favoring cholecalciferol in raising levels in blood, although more research is needed.
A much less common use of cholecalciferol therapy in rickets utilizes a single large dose and has been called stoss therapy. Treatment is given either orally or by intramuscular injection of 300,000 IU (7,500 μg) to 500,000 IU (12,500 μg = 12.5 mg), in a single dose, or sometimes in two to four divided doses. There are concerns about the safety of such large doses.
Low circulating vitamin D levels have been associated with lower total testosterone levels in males. Vitamin D supplementation could potentially improve total testosterone concentration, although more research is needed.
A meta-analysis of 2007 concluded that daily intake of 1000 to 2000 IU per day of vitamin D3 could reduce the incidence of colorectal cancer with minimal risk. Also a 2008 study published in Cancer Research has shown the addition of vitamin D3 (along with calcium) to the diet of some mice fed a regimen similar in nutritional content to a new Western diet with 1000 IU cholecalciferol per day prevented colon cancer development. In humans, with 400 IU daily, there was no effect of cholecalciferol supplements on the risk of colorectal cancer.
Supplements are not recommended for prevention of cancer as any effects of cholecalciferol are very small. Although correlations exist between low levels of blood serum cholecalciferol and higher rates of various cancers, multiple sclerosis, tuberculosis, heart disease, and diabetes, the consensus is that supplementing levels is not beneficial. It is thought that tuberculosis may result in lower levels. It, however, is not entirely clear how the two are related.
Cholecalciferol is one of the five forms of vitamin D. Cholecalciferol is a secosteroid, that is, a steroid molecule with one ring open.
By itself cholecalciferol is inactive. It is converted to its active form by two hydroxylations: the first in the liver, by CYP2R1 or CYP27A1, to form 25-hydroxycholecalciferol (calcifediol, 25-OH vitamin D3). The second hydroxylation occurs mainly in the kidney through the action of CYP27B1 to convert 25-OH vitamin D3 into 1,25-dihydroxycholecalciferol (calcitriol, 1,25-(OH)2vitamin D3). All these metabolites are bound in blood to the vitamin D-binding protein. The action of calcitriol is mediated by the vitamin D receptor, a nuclear receptor which regulates the synthesis of hundreds of proteins and is present in virtually every cell in the body.
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7-Dehydrocholesterol is the precursor of cholecalciferol. Within the epidermal layer of skin, 7-dehydrocholesterol undergoes an electrocyclic reaction as a result of UVB light at wavelengths between 290 and 315 nm, with peak synthesis occurring between 295 and 300 nm. This results in the opening of the vitamin precursor B-ring through a conrotatory pathway making previtamin D3 (pre-cholecalciferol). In a process which is independent of UV light, the pre-cholecalciferol then undergoes a [1,7] antarafacial sigmatropic rearrangement and therein finally isomerizes to form vitamin D3.
The active UVB wavelengths are present in sunlight, and sufficient amounts of cholecalciferol can be produced with moderate exposure of the skin, depending on the strength of the sun. Time of day, season, latitude, and altitude affect the strength of the sun, and pollution, cloud cover or glass all reduce the amount of UVB exposure. Exposure of face, arms and legs, averaging 5–30 minutes twice per week, may be sufficient, but the darker the skin, and the weaker the sunlight, the more minutes of exposure are needed. Vitamin D overdose is impossible from UV exposure; the skin reaches an equilibrium where the vitamin degrades as fast as it is created.
Cholecalciferol can be produced in skin from the light emitted by the UV lamps in tanning beds, which produce ultraviolet primarily in the UVA spectrum, but typically produce 4% to 10% of the total UV emissions as UVB. Levels in blood are higher in frequent users of tanning salons.
Whether cholecalciferol and all forms of vitamin D are by definition “vitamins” can be disputed, since the definition of vitamins includes that the substance cannot be synthesized by the body and must be ingested. Cholecalciferol is synthesized by the body during UVB radiation exposure.
The three steps in the synthesis and activation of vitamin D3 are regulated as follows:
Cholecalciferol is produced industrially for use in vitamin supplements and to fortify foods. As a pharmaceutical drug it is called cholecalciferol (USAN) or colecalciferol (INN, BAN). It is produced by the ultraviolet irradiation of 7-dehydrocholesterol extracted from lanolin found in sheep’s wool. Cholesterol is extracted from wool grease and wool wax alcohols obtained from the cleaning of wool after shearing. The cholesterol undergoes a four-step process to make 7-dehydrocholesterol, the same compound that is produced in the skin of animals. The 7-dehydrocholesterol is then irradiated with ultraviolet light. Some unwanted isomers are formed during irradiation: these are removed by various techniques, leaving a resin which melts at about room temperature and usually has a potency of 25,000,000 to 30,000,000 International Units per gram.
Cholecalciferol is also produced industrially for use in vitamin supplements from lichens, which is suitable for vegans.
Cholecalciferol is very sensitive to UV radiation and will rapidly, but reversibly, break down to form supra-sterols, which can further irreversibly convert to ergosterol.
Rodents are somewhat more susceptible to high doses than other species, and cholecalciferol has been used in poison bait for the control of these pests.
The mechanism of high dose cholecalciferol is that it can produce “hypercalcemia, which results in systemic calcification of soft tissue, leading to kidney failure, cardiac abnormalities, hypertension, CNS depression, and GI upset. Signs generally develop within 18-36 hr of ingestion and can include depression, loss of appetite, polyuria, and polydipsia.” High-dose cholecalciferol will tend to rapidly accumulate in adipose tissue yet release more slowly which will tend to delay time of death for several days from the time that high-dose bait is introduced.
In New Zealand, possums have become a significant pest animal. For possum control, cholecalciferol has been used as the active ingredient in lethal baits. The LD50 is 16.8 mg/kg, but only 9.8 mg/kg if calcium carbonate is added to the bait. Kidneys and heart are target organs. LD50 of 4.4 mg/kg has been reported in rabbits, with lethality to almost all rabbits ingesting doses greater than 15 mg/kg. Toxicity has been reported across a wide range of cholecalciferol dosages, with LD50 as high as 88 mg/kg or as low as 2 mcg/kg reported for dogs.
Researchers have reported that the compound is less toxic to non-target species than earlier generations of anticoagulant rodenticides (Warfarin and congeners) or Bromethalin, and that relay toxicosis (poisoning by eating a poisoned animal) has not been documented. Nevertheless, the same source reports that use of cholecalciferol in rodenticides may still pose a significant hazard to other animals, such as dogs and cats, when rodenticide bait or other forms of cholecalciferol are directly ingested.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Cholecalciferol and Weed and an increase in anxiety.
Anyone mixing Cholecalciferol and weed is likely to experience side effects. This happens with all medications whether weed or Cholecalciferol is mixed with them. Side effects can be harmful when mixing Cholecalciferol and weed. Doctors are likely to refuse a patient a Cholecalciferol prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Cholecalciferol and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Cholecalciferol are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Cholecalciferol. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Cholecalciferol and Weed, dol not interact is wrong. There will always be an interaction between Cholecalciferol and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Cholecalciferol and Weed is Scromiting. This condition, reportedly caused by mixing Cholecalciferol and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Cholecalciferol and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Cholecalciferol and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Cholecalciferol?
The way in which the body absorbs and process Cholecalciferol may be affected by weed. Therefore, the potency of the Cholecalciferol may be less effective. Marijuana inhibits the metabolization of Cholecalciferol. Not having the right potency of Cholecalciferol means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Cholecalciferol medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Cholecalciferol medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Cholecalciferol and Weed
Many individuals may not realize that there are side effects and consequences to mixing Cholecalciferol and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Cholecalciferol and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Cholecalciferol and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Cholecalciferol and Weed is not recommended.
Taking Cholecalciferol and Weed together
People who take Cholecalciferol and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Cholecalciferol and weed depend on whether you consume more weed in relation to Cholecalciferol or more Cholecalciferol in relation to weed.
The use of significantly more weed and Cholecalciferol will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Cholecalciferol may experience effects such as:
- reduced motor reflexes from Cholecalciferol and Weed
- dizziness from Weed and Cholecalciferol
- nausea and vomiting due to Cholecalciferol and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Cholecalciferol leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Cholecalciferol
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Cholecalciferol this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Cholecalciferol affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Cholecalciferol and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Cholecalciferol can be just as harmful and there is no way of knowing exactly how Cholecalciferol and weed is going to affect an individual before they take it.
Taking Cholecalciferol and weed together
People who take Cholecalciferol and weed together will experience the effects of both substances. The use of significantly more Cholecalciferol with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Cholecalciferol may experience effects such as:
- reduced motor reflexes from Cholecalciferol and weed
- dizziness from weed and Cholecalciferol
- nausea and vomiting of the Cholecalciferol
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Cholecalciferol leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Cholecalciferol
Taking Cholecalciferol in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Cholecalciferol and weed may have difficulty forming new memories. With weed vs Cholecalciferol in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Cholecalciferol when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Cholecalciferol and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Cholecalciferol Vs Weed
Studies investigating the effects of drugs such as Cholecalciferol and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Cholecalciferol and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Cholecalciferol together.
When a small to medium amount of weed is combined with Cholecalciferol, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Cholecalciferol.
How long after taking Cholecalciferol can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Cholecalciferol has totally cleared your system before taking weed, even in small quantities.
Overdose on Cholecalciferol and weed
In the case of Overdose on Cholecalciferol or if you are worried after mixing Cholecalciferol and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Cholecalciferol or mixed weed with Cholecalciferol then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Cholecalciferol and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Cholecalciferol and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Cholecalciferol and weed. These individuals may not realize that there are side effects and consequences to consuming both Cholecalciferol, marijuana and a range of antidepressants.
Studies on weed, Cholecalciferol and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Cholecalciferol
A lot of people suffer from depression caused by weed and Cholecalciferol. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Cholecalciferol and weed
Quitting weed to take Cholecalciferol
Medical professionals say an individual prescribed or taking Cholecalciferol should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Cholecalciferol.
A person beginning to use Cholecalciferol should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Cholecalciferol can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Cholecalciferol may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Cholecalciferol and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Cholecalciferol or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Cholecalciferol from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Cholecalciferol.
If you take Cholecalciferol, and also drink Alcohol or MDMA, you can research the effects of Cholecalciferol and Alcohol , Cholecalciferol and Cocaine as well as Cholecalciferol and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Cholecalciferol and Weed
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