Chlor-Trimeton and Weed
Edited by Hugh Soames
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Chlor-Trimeton and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Chlor-Trimeton. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Chlor-Trimeton and Weed.
Mixing Chlor-Trimeton and Weed
Chlorphenamine (CP, CPM), also known as chlorpheniramine, is an antihistamine used to treat the symptoms of allergic conditions such as allergic rhinitis (hay fever). It is taken orally (by mouth). The medication takes effect within two hours and lasts for about 4-6 hours.
Common side effects include sleepiness, restlessness, and weakness. Other side effects may include dry mouth and wheeziness. It is a first-generation antihistamine and works by blocking the H1 receptor.
Chlorpheniramine was patented in 1948 and came into medical use in 1949. It is available as a generic medication and over the counter.
Chlorphenamine is often combined with phenylpropanolamine to form an allergy medication with both antihistamine and decongestant properties, though phenylpropanolamine is no longer available in the US after studies showed it increased the risk of stroke in young women. Chlorphenamine remains available with no such risk.
Chlorphenamine may be combined with the opioid hydrocodone. Chlorphenamine/dihydrocodeine immediate-release syrups are also marketed. The antihistamine is helpful in cases where allergy or common cold is the reason for the cough; it is also a potentiator of opioids, allowing enhanced suppression of cough, analgesia, and other effects from a given quantity of the drug by itself. In various places in the world, cough and cold preparations containing codeine and chlorphenamine are available.
In the drug Coricidin, chlorphenamine is combined with the cough suppressant dextromethorphan. In the drug Cêgripe, chlorphenamine is combined with the analgesic paracetamol.
The adverse effects include drowsiness, dizziness, confusion, constipation, anxiety, nausea, blurred vision, restlessness, decreased coordination, dry mouth, shallow breathing, hallucinations, irritability, problems with memory or concentration, tinnitus and trouble urinating.
Chlorphenamine produces less sedation than other first-generation antihistamines.
A large study on people 65 years old or older, linked the development of Alzheimer’s disease and other forms of dementia to the “higher cumulative” use of chlorphenamine and other first-generation antihistamines, due to their anticholinergic properties.
Chlorphenamine acts primarily as a potent H1 antihistamine. It is specifically a potent inverse agonist of the histamine H1 receptor. The drug is also commonly described as possessing weak anticholinergic activity by acting as an antagonist of the muscarinic acetylcholine receptors. The dextrorotatory stereoisomer, dexchlorpheniramine, has been reported to possess Kd values of 15 nM for the H1 receptor and 1,300 nM for the muscarinic acetylcholine receptors in human brain tissue. The smaller the Kd value, the greater the binding affinity of the ligand for its target.
In addition to acting as an inverse agonist at the H1 receptor, chlorphenamine has been found to act as a serotonin reuptake inhibitor (Kd = 15.2 nM for the serotonin transporter). It has only weak affinity for the norepinephrine and dopamine transporters (Kd = 1,440 nM and 1,060 nM, respectively). A similar antihistamine, brompheniramine, led to the discovery of the selective serotonin reuptake inhibitor (SSRI) zimelidine.[citation needed]
A study found that dexchlorphenamine had Ki values for the human cloned H1 receptor of 2.67 to 4.81 nM while levchlorphenamine had Ki values of 211 to 361 nM for this receptor, indicating that dexchlorphenamine is the active enantiomer. Another study found that dexchlorphenamine had a Ki value of 20 to 30 μM for the muscarinic acetylcholine receptor using rat brain tissue while levchlorphenamine had a Ki value of 40 to 50 μM for this receptor, indicating that both enantiomers have very low affinity for it.
The elimination half-life of chlorphenamine has variously ranged between 13.9 and 43.4 hours in adults following a single dose in clinical studies.
Chlorphenamine is an alkylamine and is a part of a series of antihistamines including pheniramine (Naphcon) and its halogenated derivatives including fluorpheniramine, dexchlorphenamine (Polaramine), brompheniramine (Dimetapp), dexbrompheniramine (Drixoral), deschlorpheniramine, and iodopheniramine. The halogenated alkylamine antihistamines all exhibit optical isomerism, and chlorphenamine in the indicated products is racemic chlorphenamine maleate, whereas dexchlorphenamine is the dextrorotary stereoisomer.
There are several patented methods for the synthesis of chlorphenamine. In one example, 4-chlorophenylacetonitrile is reacted with 2-chloropyridine in the presence of sodium amide to form 4-chlorophenyl(2-pyridyl)acetonitrile. Alkylating this with 2-dimethylaminoethylchloride in the presence of sodium amide gives γ-(4-chlorphenyl)-γ-cyano-N,N-dimethyl-2-pyridinepropanamine, the hydrolysis and decarboxylation of which lead to chlorphenamine.
A second method boom starts from pyridine, which undergoes alkylation by 4-chlorophenylacetonitrile, giving 2-(4-chlorobenzyl)pyridine. Alkylating this with 2-dimethylaminoethylchloride in the presence of sodium amide gives chlorphenamine.
Chlorphenamine is the INN while chlorpheniramine is the USAN and former BAN.
Brand names include Chlor-Trimeton, Demazin, Allerest 12 Hour, Piriton, Chlorphen-12, Tylenol Cold/Allergy, and numerous others according to country.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Chlor-Trimeton and Weed and an increase in anxiety.
Anyone mixing Chlor-Trimeton and weed is likely to experience side effects. This happens with all medications whether weed or Chlor-Trimeton is mixed with them. Side effects can be harmful when mixing Chlor-Trimeton and weed. Doctors are likely to refuse a patient a Chlor-Trimeton prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Chlor-Trimeton and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Chlor-Trimeton are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Chlor-Trimeton. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Chlor-Trimeton and Weed, dol not interact is wrong. There will always be an interaction between Chlor-Trimeton and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Chlor-Trimeton and Weed is Scromiting. This condition, reportedly caused by mixing Chlor-Trimeton and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Chlor-Trimeton and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Chlor-Trimeton and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Chlor-Trimeton?
The way in which the body absorbs and process Chlor-Trimeton may be affected by weed. Therefore, the potency of the Chlor-Trimeton may be less effective. Marijuana inhibits the metabolization of Chlor-Trimeton. Not having the right potency of Chlor-Trimeton means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Chlor-Trimeton medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Chlor-Trimeton medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Chlor-Trimeton and Weed
Many individuals may not realize that there are side effects and consequences to mixing Chlor-Trimeton and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Chlor-Trimeton and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Chlor-Trimeton and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Chlor-Trimeton and Weed is not recommended.
Taking Chlor-Trimeton and Weed together
People who take Chlor-Trimeton and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Chlor-Trimeton and weed depend on whether you consume more weed in relation to Chlor-Trimeton or more Chlor-Trimeton in relation to weed.
The use of significantly more weed and Chlor-Trimeton will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Chlor-Trimeton may experience effects such as:
- reduced motor reflexes from Chlor-Trimeton and Weed
- dizziness from Weed and Chlor-Trimeton
- nausea and vomiting due to Chlor-Trimeton and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Chlor-Trimeton leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Chlor-Trimeton
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Chlor-Trimeton this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Chlor-Trimeton affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Chlor-Trimeton and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Chlor-Trimeton can be just as harmful and there is no way of knowing exactly how Chlor-Trimeton and weed is going to affect an individual before they take it.
Taking Chlor-Trimeton and weed together
People who take Chlor-Trimeton and weed together will experience the effects of both substances. The use of significantly more Chlor-Trimeton with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Chlor-Trimeton may experience effects such as:
- reduced motor reflexes from Chlor-Trimeton and weed
- dizziness from weed and Chlor-Trimeton
- nausea and vomiting of the Chlor-Trimeton
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Chlor-Trimeton leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Chlor-Trimeton
Taking Chlor-Trimeton in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Chlor-Trimeton and weed may have difficulty forming new memories. With weed vs Chlor-Trimeton in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Chlor-Trimeton when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Chlor-Trimeton and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Chlor-Trimeton Vs Weed
Studies investigating the effects of drugs such as Chlor-Trimeton and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Chlor-Trimeton and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Chlor-Trimeton together.
When a small to medium amount of weed is combined with Chlor-Trimeton, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Chlor-Trimeton.
How long after taking Chlor-Trimeton can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Chlor-Trimeton has totally cleared your system before taking weed, even in small quantities.
Overdose on Chlor-Trimeton and weed
In the case of Overdose on Chlor-Trimeton or if you are worried after mixing Chlor-Trimeton and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Chlor-Trimeton or mixed weed with Chlor-Trimeton then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Chlor-Trimeton and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Chlor-Trimeton and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Chlor-Trimeton and weed. These individuals may not realize that there are side effects and consequences to consuming both Chlor-Trimeton, marijuana and a range of antidepressants.
Studies on weed, Chlor-Trimeton and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Chlor-Trimeton
A lot of people suffer from depression caused by weed and Chlor-Trimeton. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Chlor-Trimeton and weed
Quitting weed to take Chlor-Trimeton
Medical professionals say an individual prescribed or taking Chlor-Trimeton should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Chlor-Trimeton.
A person beginning to use Chlor-Trimeton should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Chlor-Trimeton can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Chlor-Trimeton may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Chlor-Trimeton and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Chlor-Trimeton or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Chlor-Trimeton from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Chlor-Trimeton.
If you take Chlor-Trimeton, and also drink Alcohol or MDMA, you can research the effects of Chlor-Trimeton and Alcohol , Chlor-Trimeton and Cocaine as well as Chlor-Trimeton and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Chlor-Trimeton and Weed
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