Cesamet and Weed
Edited by Hugh Soames
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Cesamet and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Cesamet. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Cesamet and Weed.
Mixing Cesamet and Weed
Nabilone, sold under the brand name Cesamet among others, is a synthetic cannabinoid with therapeutic use as an antiemetic and as an adjunct analgesic for neuropathic pain. It mimics tetrahydrocannabinol (THC), the primary psychoactive compound found naturally occurring in Cannabis.
The Food and Drug Administration in the United States has indicated nabilone for chemotherapy-induced nausea/vomiting. In other countries, such as Canada, it is widely used as an adjunct therapy for chronic pain management. Numerous trials and case studies have demonstrated modest effectiveness for relieving fibromyalgia and multiple sclerosis.
Nabilone is used to treat nausea and vomiting in people under chemotherapy.
Nabilone has shown modest effectiveness in relieving fibromyalgia. A 2011 systematic review of cannabinoids for chronic pain determined there was evidence of safety and modest efficacy for some conditions.
The main settings that have seen published clinical trials of nabilone include movement disorders such as parkinsonism, chronic pain, dystonia and spasticity neurological disorders, multiple sclerosis, and the nausea of cancer chemotherapy. Nabilone is also effective in the treatment of inflammatory bowel disease, especially ulcerative colitis.
In one study of current daily users of cannabis, oral nabilone at 4, 6, and 8 mg produced sustained and dose-dependent mood elevation and psychomotor slowing comparable to 10 or 20 mg oral dronabinol (THC). Nabilone had a slower onset of peak action and a greater dose-dependence of effects, which the investigators attributed to greater bioavailability.
A study comparing nabilone with metoclopramide, conducted before the development of modern 5-HT3 antagonist anti-emetics such as ondansetron, revealed that patients taking cisplatin chemotherapy preferred metoclopramide, while patients taking carboplatin preferred nabilone to control nausea and vomiting.
Nabilone is sometimes used for nightmares in post-traumatic stress disorder, but there have not been studies longer than nine weeks, so effects of longer-term use are not known. Nabilone has also been used for medication overuse headache.
Nabilone can increase – rather than decrease – postoperative pain. In the treatment of fibromyalgia, adverse effects limit the useful dose. Adverse effects of nabilone include, but are not limited to: dizziness/vertigo, euphoria, drowsiness, dry mouth, ataxia, sleep disturbance, headache, nausea, disorientation, depersonalization, hallucinations, and asthenia.
Nabilone is a partial agonist of the cannabinoid CB1 and CB2 receptors.
Nabilone is given in 1 or 2 mg doses multiple times a day up to a total of 6 mg. It is completely absorbed from oral administration and highly plasma protein bound. Multiple cytochrome P450 enzymes extensively metabolize nabilone to various metabolites that have not been fully characterized.
Nabilone is a racemic mixture consisting of (S,S)-(+)- and (R,R)-(−)-isomers.
Nabilone was originally developed by Eli Lilly and Company; and was first approved by Health Canada in 1981; shortly followed by its approval in Mexico, the United Kingdom, and Germany. Lilly received FDA approval in 1985 to market it, but withdrew that approval in 1989 for commercial reasons. Valeant Pharmaceuticals acquired the rights from Lilly in 2004. Valeant tried and failed to get the medication approved by the FDA again in 2005 and then succeeded in 2006.
In 2007, Valeant acquired the United Kingdom and European Union rights to market nabilone from Cambridge Laboratories.
Nabilone was approved in Austria to treat chemotherapy-induced nausea in 2013; it was already approved in Spain for the same indication and was legal in Belgium to treat glaucoma, spasticity in multiple sclerosis, wasting due to AIDS, and chronic pain.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Cesamet and Weed and an increase in anxiety.
Anyone mixing Cesamet and weed is likely to experience side effects. This happens with all medications whether weed or Cesamet is mixed with them. Side effects can be harmful when mixing Cesamet and weed. Doctors are likely to refuse a patient a Cesamet prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Cesamet and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Cesamet are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Cesamet. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Cesamet and Weed, dol not interact is wrong. There will always be an interaction between Cesamet and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Cesamet and Weed is Scromiting. This condition, reportedly caused by mixing Cesamet and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Cesamet and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Cesamet and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Cesamet?
The way in which the body absorbs and process Cesamet may be affected by weed. Therefore, the potency of the Cesamet may be less effective. Marijuana inhibits the metabolization of Cesamet. Not having the right potency of Cesamet means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Cesamet medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Cesamet medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Cesamet and Weed
Many individuals may not realize that there are side effects and consequences to mixing Cesamet and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Cesamet and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Cesamet and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Cesamet and Weed is not recommended.
Taking Cesamet and Weed together
People who take Cesamet and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Cesamet and weed depend on whether you consume more weed in relation to Cesamet or more Cesamet in relation to weed.
The use of significantly more weed and Cesamet will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Cesamet may experience effects such as:
- reduced motor reflexes from Cesamet and Weed
- dizziness from Weed and Cesamet
- nausea and vomiting due to Cesamet and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Cesamet leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Cesamet
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Cesamet this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Cesamet affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Cesamet and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Cesamet can be just as harmful and there is no way of knowing exactly how Cesamet and weed is going to affect an individual before they take it.
Taking Cesamet and weed together
People who take Cesamet and weed together will experience the effects of both substances. The use of significantly more Cesamet with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Cesamet may experience effects such as:
- reduced motor reflexes from Cesamet and weed
- dizziness from weed and Cesamet
- nausea and vomiting of the Cesamet
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Cesamet leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Cesamet
Taking Cesamet in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Cesamet and weed may have difficulty forming new memories. With weed vs Cesamet in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Cesamet when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Cesamet and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Cesamet Vs Weed
Studies investigating the effects of drugs such as Cesamet and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Cesamet and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Cesamet together.
When a small to medium amount of weed is combined with Cesamet, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Cesamet.
How long after taking Cesamet can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Cesamet has totally cleared your system before taking weed, even in small quantities.
Overdose on Cesamet and weed
In the case of Overdose on Cesamet or if you are worried after mixing Cesamet and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Cesamet or mixed weed with Cesamet then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Cesamet and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Cesamet and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Cesamet and weed. These individuals may not realize that there are side effects and consequences to consuming both Cesamet, marijuana and a range of antidepressants.
Studies on weed, Cesamet and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Cesamet
A lot of people suffer from depression caused by weed and Cesamet. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Cesamet and weed
Quitting weed to take Cesamet
Medical professionals say an individual prescribed or taking Cesamet should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Cesamet.
A person beginning to use Cesamet should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Cesamet can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Cesamet may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Cesamet and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Cesamet or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Cesamet from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Cesamet.
If you take Cesamet, and also drink Alcohol or MDMA, you can research the effects of Cesamet and Alcohol , Cesamet and Cocaine as well as Cesamet and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Cesamet and Weed
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