Carmustine and Weed
Edited by Hugh Soames
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Carmustine and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Carmustine. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Carmustine and Weed.
Mixing Carmustine and Weed
Carmustine, sold under the brand name BiCNU among others, is a medication used mainly for chemotherapy. It is a nitrogen mustard β-chloro-nitrosourea compound used as an alkylating agent.
Carmustine is an orange-yellow solid medication used mainly for chemotherapy. It is a nitrogen mustard β-chloro-nitrosourea compound.
As an alkylating agent, carmustine can form interstrand crosslinks in DNA, which prevents DNA replication and DNA transcription.
Carmustine is used as an alkylating agent to treat several types of brain cancer including glioma, glioblastoma multiforme, medulloblastoma and astrocytoma, multiple myeloma, and lymphoma (Hodgkin’s and non-Hodgkin).
Carmustine is sometimes used in conjunction with alkyl guanine transferase (AGT) inhibitors, such as O-benzylguanine. The AGT-inhibitors increase the efficacy of carmustine by inhibiting the direct reversal pathway of DNA repair, which will prevent formation of the interstrand crosslink between the N1 of guanine and the N of cytosine.
It is also used as part of a chemotherapeutic protocol in preparation for hematological stem cell transplantation, a type of bone marrow transplant, in order to reduce the white blood cell count in the recipient. Use under this protocol, usually with fludarabine and melphalan, was developed by oncologists at the University of Texas MD Anderson Cancer Center.[citation needed]
In the treatment of brain tumours, the U.S. Food and Drug Administration (FDA) approved biodegradable discs infused with carmustine (Gliadel). They are implanted under the skull during a surgery called a craniotomy. The disc allows for controlled release of carmustine in the extracellular fluid of the brain, thus eliminating the need for the encapsulated drug to cross the blood-brain barrier.
Carmustine for injection was marketed under the name BiCNU by Bristol-Myers Squibb and now[when?] by Emcure Pharmaceuticals. In India it is sold under various brand names, including Consium.[citation needed]. The product is available as a generic version with other manufacturers offering the product licensed in the US and EU markets.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Carmustine and Weed and an increase in anxiety.
Anyone mixing Carmustine and weed is likely to experience side effects. This happens with all medications whether weed or Carmustine is mixed with them. Side effects can be harmful when mixing Carmustine and weed. Doctors are likely to refuse a patient a Carmustine prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Carmustine and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Carmustine are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Carmustine. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Carmustine and Weed, dol not interact is wrong. There will always be an interaction between Carmustine and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Carmustine and Weed is Scromiting. This condition, reportedly caused by mixing Carmustine and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Carmustine and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Carmustine and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Carmustine?
The way in which the body absorbs and process Carmustine may be affected by weed. Therefore, the potency of the Carmustine may be less effective. Marijuana inhibits the metabolization of Carmustine. Not having the right potency of Carmustine means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Carmustine medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Carmustine medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Carmustine and Weed
Many individuals may not realize that there are side effects and consequences to mixing Carmustine and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Carmustine and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Carmustine and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Carmustine and Weed is not recommended.
Taking Carmustine and Weed together
People who take Carmustine and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Carmustine and weed depend on whether you consume more weed in relation to Carmustine or more Carmustine in relation to weed.
The use of significantly more weed and Carmustine will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Carmustine may experience effects such as:
- reduced motor reflexes from Carmustine and Weed
- dizziness from Weed and Carmustine
- nausea and vomiting due to Carmustine and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Carmustine leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Carmustine
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Carmustine this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Carmustine affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Carmustine and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Carmustine can be just as harmful and there is no way of knowing exactly how Carmustine and weed is going to affect an individual before they take it.
Taking Carmustine and weed together
People who take Carmustine and weed together will experience the effects of both substances. The use of significantly more Carmustine with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Carmustine may experience effects such as:
- reduced motor reflexes from Carmustine and weed
- dizziness from weed and Carmustine
- nausea and vomiting of the Carmustine
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Carmustine leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Carmustine
Taking Carmustine in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Carmustine and weed may have difficulty forming new memories. With weed vs Carmustine in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Carmustine when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Carmustine and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Carmustine Vs Weed
Studies investigating the effects of drugs such as Carmustine and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Carmustine and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Carmustine together.
When a small to medium amount of weed is combined with Carmustine, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Carmustine.
How long after taking Carmustine can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Carmustine has totally cleared your system before taking weed, even in small quantities.
Overdose on Carmustine and weed
In the case of Overdose on Carmustine or if you are worried after mixing Carmustine and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Carmustine or mixed weed with Carmustine then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Carmustine and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Carmustine and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Carmustine and weed. These individuals may not realize that there are side effects and consequences to consuming both Carmustine, marijuana and a range of antidepressants.
Studies on weed, Carmustine and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Carmustine
A lot of people suffer from depression caused by weed and Carmustine. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Carmustine and weed
Quitting weed to take Carmustine
Medical professionals say an individual prescribed or taking Carmustine should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Carmustine.
A person beginning to use Carmustine should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Carmustine can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Carmustine may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Carmustine and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Carmustine or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Carmustine from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Carmustine.
If you take Carmustine, and also drink Alcohol or MDMA, you can research the effects of Carmustine and Alcohol , Carmustine and Cocaine as well as Carmustine and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Carmustine and Weed
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