Carbatrol and Weed
Edited by Hugh Soames
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Carbatrol and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Carbatrol. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Carbatrol and Weed.
Mixing Carbatrol and Weed
Carbamazepine, sold under the brand name Tegretol among others, is an anticonvulsant medication used in the treatment of epilepsy and neuropathic pain. It is used as an adjunctive treatment in schizophrenia along with other medications and as a second-line agent in bipolar disorder. Carbamazepine appears to work as well as phenytoin and valproate for focal and generalized seizures. It is not effective for absence or myoclonic seizures.
Carbamazepine was discovered in 1953 by Swiss chemist Walter Schindler. It was first marketed in 1962. It is available as a generic medication. It is on the World Health Organization’s List of Essential Medicines. In 2020, it was the 185th most commonly prescribed medication in the United States, with more than 2 million prescriptions.
Carbamazepine is typically used for the treatment of seizure disorders and neuropathic pain. It is used off-label as a second-line treatment for bipolar disorder and in combination with an antipsychotic in some cases of schizophrenia when treatment with a conventional antipsychotic alone has failed. However, evidence does not support its usage for schizophrenia. It is not effective for absence seizures or myoclonic seizures. Although carbamazepine may have a similar effectiveness (as measured by people continuing to use a medication) and efficacy (as measured by the medicine reducing seizure recurrence and improving remission) when compared to phenytoin and valproate, choice of medication should be evaluated on an individual basis as further research is needed to determine which medication is most helpful for people with newly-onset seizures.
In the United States, carbamazepine is indicated for the treatment of epilepsy (including partial seizures, generalized tonic-clonic seizures and mixed seizures), and trigeminal neuralgia. Carbamazepine is the only medication that is approved by the Food and Drug Administration for the treatment of trigeminal neuralgia.
As of 2014, a controlled release formulation was available for which there is tentative evidence showing fewer side effects and unclear evidence with regard to whether there is a difference in efficacy.
In the US, the label for carbamazepine contains warnings concerning:
Common adverse effects may include drowsiness, dizziness, headaches and migraines, motor coordination impairment, nausea, vomiting, and/or constipation. Alcohol use while taking carbamazepine may lead to enhanced depression of the central nervous system. Less common side effects may include increased risk of seizures in people with mixed seizure disorders, abnormal heart rhythms, blurry or double vision. Also, rare case reports of an auditory side effect have been made, whereby patients perceive sounds about a semitone lower than previously; this unusual side effect is usually not noticed by most people, and disappears after the person stops taking carbamazepine.
In a systematic review, the authors identified seventy-three reports containing one-hundred ninety-one individuals who developed movement disorders associated with carbamazepine, oxcarbazepine, and eslicarbazepine. The abnormal movements encountered were myoclonus, dystonia, tics, dyskinesia, parkinsonism, akathisia, and unclear incoordination.
Serious skin reactions such as Stevens–Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) due to carbamazepine therapy are more common in people with a particular human leukocyte antigen gene-variant (allele), HLA-B*1502. Odds ratios for the development of SJS or TEN in people who carry the allele can be in the double, triple or even quadruple digits, depending on the population studied. HLA-B*1502 occurs almost exclusively in people with ancestry across broad areas of Asia, but has a very low or absent frequency in European, Japanese, Korean and African populations. However, the HLA-A*31:01 allele has been shown to be a strong predictor of both mild and severe adverse reactions, such as the DRESS form of severe cutaneous reactions, to carbamazepine among Japanese, Chinese, Korean, and Europeans. It is suggested that carbamazepine acts as a potent antigen that binds to the antigen-presenting area of HLA-B*1502 alike, triggering an everlasting activation signal on immature CD8-T cells, thus resulting in widespread cytotoxic reactions like SJS/TEN.
Carbamazepine has a potential for drug interactions. Drugs that decrease breaking down of carbamazepine or otherwise increase its levels include erythromycin, cimetidine, propoxyphene, and calcium channel blockers. Grapefruit juice raises the bioavailability of carbamazepine by inhibiting the enzyme CYP3A4 in the gut wall and in the liver. Lower levels of carbamazepine are seen when administrated with phenobarbital, phenytoin, or primidone, which can result in breakthrough seizure activity.
Valproic acid and valnoctamide both inhibit microsomal epoxide hydrolase (mEH), the enzyme responsible for the breakdown of the active metabolite carbamazepine-10,11-epoxide into inactive metabolites. By inhibiting mEH, valproic acid and valnoctamide cause a build-up of the active metabolite, prolonging the effects of carbamazepine and delaying its excretion.
Carbamazepine, as an inducer of cytochrome P450 enzymes, may increase clearance of many drugs, decreasing their concentration in the blood to subtherapeutic levels and reducing their desired effects. Drugs that are more rapidly metabolized with carbamazepine include warfarin, lamotrigine, phenytoin, theophylline, valproic acid, many benzodiazepines, and methadone. Carbamazepine also increases the metabolism of the hormones in birth control pills and can reduce their effectiveness, potentially leading to unexpected pregnancies.
Carbamazepine is a sodium channel blocker. It binds preferentially to voltage-gated sodium channels in their inactive conformation, which prevents repetitive and sustained firing of an action potential. Carbamazepine has effects on serotonin systems but the relevance to its antiseizure effects is uncertain. There is evidence that it is a serotonin releasing agent and possibly even a serotonin reuptake inhibitor. It has been suggested that carbamazepine can also block voltage-gated calcium channels, which will reduce neurotransmitter release.
Carbamazepine is relatively slowly but practically completely absorbed after administration by mouth. Highest concentrations in the blood plasma are reached after 4 to 24 hours depending on the dosage form. Slow release tablets result in about 15% lower absorption and 25% lower peak plasma concentrations than ordinary tablets, as well as in less fluctuation of the concentration, but not in significantly lower minimum concentrations.
In the circulation, carbamazepine itself comprises 20 to 30% of total residues. The remainder is in the form of metabolites; 70 to 80% of residues is bound to plasma proteins. Concentrations in breast milk are 25 to 60% of those in the blood plasma.
Carbamazepine itself is not pharmacologically active. It is activated, mainly by CYP3A4, to carbamazepine-10,11-epoxide, which is solely responsible for the drug’s anticonvulsant effects. The epoxide is then inactivated by microsomal epoxide hydrolase (mEH) to carbamazepine-trans-10,11-diol and further to its glucuronides. Other metabolites include various hydroxyl derivatives and carbamazepine-N-glucuronide.
The plasma half-life is about 35 to 40 hours when carbamazepine is given as single dose, but it is a strong inducer of liver enzymes, and the plasma half-life shortens to about 12 to 17 hours when it is given repeatedly. The half-life can be further shortened to 9–10 hours by other enzyme inducers such as phenytoin or phenobarbital. About 70% are excreted via the urine, almost exclusively in form of its metabolites, and 30% via the faeces.
Carbamazepine was discovered by chemist Walter Schindler at J.R. Geigy AG (now part of Novartis) in Basel, Switzerland, in 1953. It was first marketed as a drug to treat epilepsy in Switzerland in 1963 under the brand name Tegretol; its use for trigeminal neuralgia (formerly known as tic douloureux) was introduced at the same time. It has been used as an anticonvulsant and antiepileptic in the United Kingdom since 1965, and has been approved in the United States since 1968.
Carbamazepine was studied for bipolar disorder throughout the 1970s.
Carbamazepine and its bio-transformation products have been detected in wastewater treatment plant effluent: 224 and in streams receiving treated wastewater. Field and laboratory studies have been conducted to understand the accumulation of carbamazepine in food plants grown in soil treated with sludge, which vary with respect to the concentrations of carbamazepine present in sludge and in the concentrations of sludge in the soil. Taking into account only studies that used concentrations commonly found in the environment, a 2014 review concluded that “the accumulation of carbamazepine into plants grown in soil amended with biosolids poses a de minimis risk to human health according to the approach.”
Carbamazepine is available worldwide under many brand names including Tegretol.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Carbatrol and Weed and an increase in anxiety.
Anyone mixing Carbatrol and weed is likely to experience side effects. This happens with all medications whether weed or Carbatrol is mixed with them. Side effects can be harmful when mixing Carbatrol and weed. Doctors are likely to refuse a patient a Carbatrol prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Carbatrol and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Carbatrol are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Carbatrol. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Carbatrol and Weed, dol not interact is wrong. There will always be an interaction between Carbatrol and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Carbatrol and Weed is Scromiting. This condition, reportedly caused by mixing Carbatrol and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Carbatrol and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Carbatrol and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Carbatrol?
The way in which the body absorbs and process Carbatrol may be affected by weed. Therefore, the potency of the Carbatrol may be less effective. Marijuana inhibits the metabolization of Carbatrol. Not having the right potency of Carbatrol means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Carbatrol medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Carbatrol medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Carbatrol and Weed
Many individuals may not realize that there are side effects and consequences to mixing Carbatrol and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Carbatrol and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Carbatrol and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Carbatrol and Weed is not recommended.
Taking Carbatrol and Weed together
People who take Carbatrol and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Carbatrol and weed depend on whether you consume more weed in relation to Carbatrol or more Carbatrol in relation to weed.
The use of significantly more weed and Carbatrol will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Carbatrol may experience effects such as:
- reduced motor reflexes from Carbatrol and Weed
- dizziness from Weed and Carbatrol
- nausea and vomiting due to Carbatrol and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Carbatrol leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Carbatrol
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Carbatrol this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Carbatrol affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Carbatrol and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Carbatrol can be just as harmful and there is no way of knowing exactly how Carbatrol and weed is going to affect an individual before they take it.
Taking Carbatrol and weed together
People who take Carbatrol and weed together will experience the effects of both substances. The use of significantly more Carbatrol with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Carbatrol may experience effects such as:
- reduced motor reflexes from Carbatrol and weed
- dizziness from weed and Carbatrol
- nausea and vomiting of the Carbatrol
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Carbatrol leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Carbatrol
Taking Carbatrol in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Carbatrol and weed may have difficulty forming new memories. With weed vs Carbatrol in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Carbatrol when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Carbatrol and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Carbatrol Vs Weed
Studies investigating the effects of drugs such as Carbatrol and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Carbatrol and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Carbatrol together.
When a small to medium amount of weed is combined with Carbatrol, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Carbatrol.
How long after taking Carbatrol can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Carbatrol has totally cleared your system before taking weed, even in small quantities.
Overdose on Carbatrol and weed
In the case of Overdose on Carbatrol or if you are worried after mixing Carbatrol and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Carbatrol or mixed weed with Carbatrol then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Carbatrol and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Carbatrol and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Carbatrol and weed. These individuals may not realize that there are side effects and consequences to consuming both Carbatrol, marijuana and a range of antidepressants.
Studies on weed, Carbatrol and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Carbatrol
A lot of people suffer from depression caused by weed and Carbatrol. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Carbatrol and weed
Quitting weed to take Carbatrol
Medical professionals say an individual prescribed or taking Carbatrol should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Carbatrol.
A person beginning to use Carbatrol should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Carbatrol can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Carbatrol may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Carbatrol and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Carbatrol or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Carbatrol from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Carbatrol.
If you take Carbatrol, and also drink Alcohol or MDMA, you can research the effects of Carbatrol and Alcohol , Carbatrol and Cocaine as well as Carbatrol and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Carbatrol and Weed
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