Capoten and Weed
Edited by Hugh Soames
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Capoten and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Capoten. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Capoten and Weed.
Mixing Capoten and Weed
Captopril, sold under the brand name Capoten among others, is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of congestive heart failure. Captopril was the first oral ACE inhibitor found for the treatment of hypertension. It does not cause fatigue as associated with beta-blockers. Due to the adverse drug event of causing hyperkalemia, as seen with most ACE Inhibitors, the medication is usually paired with a diuretic.
Captopril was patented in 1976 and approved for medical use in 1980.
Captopril has an L-proline group which allows for it to be more bioavailable within oral formulations. The thiol moiety within the molecule has been associated with two significance adverse effects: the hapten or immune response. This immune response, also known as agranulocytosis, can explain the adverse drug events which may be seen in captopril with the allergic response, which would be: hives, severe stomach pain, difficulty breathing, swelling of the face, lips, tongue or throat.
In terms of interaction with the enzyme, the molecule’s thiol moiety will attach to the binding site of the ACE enzyme. This will inhibit the port at which the angiotensin-1 molecule would normally bind, therefore inhibiting the downstream effects within the renin-angiotensin system.
Captopril’s main uses are based on its vasodilation and inhibition of some renal function activities. These benefits are most clearly seen in:
Additionally, it has shown mood-elevating properties in some patients. This is consistent with the observation that animal screening models indicate putative antidepressant activity for this compound, although one study has been negative. Formal clinical trials in depressed patients have not been reported.
It has also been investigated for use in the treatment of cancer. Captopril stereoisomers were also reported to inhibit some metallo-β-lactamases.
Adverse effects of captopril include cough due to increase in the plasma levels of bradykinin, angioedema, agranulocytosis, proteinuria, hyperkalemia, taste alteration, teratogenicity, postural hypotension, acute renal failure, and leukopenia.
Except for postural hypotension, which occurs due to the short and fast mode of action of captopril, most of the side effects mentioned are common for all ACE inhibitors. Among these, cough is the most common adverse effect. Hyperkalemia can occur, especially if used with other drugs which elevate potassium level in blood, such as potassium-sparing diuretics. Other side effects are:
The adverse drug reaction (ADR) profile of captopril is similar to other ACE inhibitors, with cough being the most common ADR. However, captopril is also commonly associated with rash and taste disturbances (metallic or loss of taste), which are attributed to the unique thiol moiety.
ACE inhibitor overdose can be treated with naloxone.
In the late 1960s, John Vane of the Royal College of Surgeons of England was working on mechanisms by which the body regulates blood pressure. He was joined by Sérgio Henrique Ferreira of Brazil, who had been studying the venom of a Brazilian pit viper, the jararaca (Bothrops jararaca), and brought a sample of the viper’s venom. Vane’s team found that one of the venom’s peptides selectively inhibited the action of angiotensin-converting enzyme (ACE), which was thought to function in blood pressure regulation; the snake venom functions by severely depressing blood pressure. During the 1970s, ACE was found to elevate blood pressure by controlling the release of water and salts from the kidneys.
Captopril, an analog of the snake venom’s ACE-inhibiting peptide, was first synthesized in 1975 by three researchers at the U.S. drug company E.R. Squibb & Sons Pharmaceuticals (now Bristol-Myers Squibb): Miguel Ondetti, Bernard Rubin, and David Cushman. Squibb filed for U.S. patent protection on the drug in February 1976, which was granted in September 1977, and captopril was approved for medical use in 1980. It was the first ACE inhibitor developed and was considered a breakthrough both because of its mechanism of action and also because of the development process. In the 1980s, Vane received the Nobel prize and was knighted for his work and Ferreira received the National Order of Scientific Merit from Brazil.
The development of captopril was among the earliest successes of the revolutionary concept of ligand-based drug design. The renin–angiotensin–aldosterone system had been extensively studied in the mid-20th century, and this system presented several opportune targets in the development of novel treatments for hypertension. The first two targets that were attempted were renin and ACE. Captopril was the culmination of efforts by Squibb’s laboratories to develop an ACE inhibitor.
Ondetti, Cushman, and colleagues built on work that had been done in the 1960s by a team of researchers led by John Vane at the Royal College of Surgeons of England. The first breakthrough was made by Kevin K.F. Ng in 1967, when he found the conversion of angiotensin I to angiotensin II took place in the pulmonary circulation instead of in the plasma. In contrast, Sergio Ferreira found bradykinin disappeared in its passage through the pulmonary circulation. The conversion of angiotensin I to angiotensin II and the inactivation of bradykinin were thought to be mediated by the same enzyme.
In 1970, using bradykinin potentiating factor (BPF) provided by Sergio Ferreira, Ng and Vane found the conversion of angiotensin I to angiotensin II was inhibited during its passage through the pulmonary circulation. BPF was later found to be a peptide in the venom of a lancehead viper (Bothrops jararaca), which was a “collected-product inhibitor” of the converting enzyme. Captopril was developed from this peptide after it was found via QSAR-based modification that the terminal sulfhydryl moiety of the peptide provided a high potency of ACE inhibition.
Captopril gained FDA approval on April 6, 1981. The drug became a generic medicine in the U.S. in February 1996, when the market exclusivity held by Bristol-Myers Squibb for captopril expired.
A chemical synthesis of captopril by treatment of L-proline with (2S)-3-acetylthio-2-methylpropanoyl chloride under basic conditions (NaOH), followed by aminolysis of the protective acetyl group to unmask the drug’s free thiol, is depicted in the figure at right.
Procedure 2 taken out of patent US4105776. See examples 28, 29a and 36.
Captopril blocks the conversion of angiotensin I to angiotensin II and prevents the degradation of vasodilatory prostaglandins, thereby inhibiting vasoconstriction and promoting systemic vasodilation.
Unlike the majority of ACE inhibitors, captopril is not administered as a prodrug (the only other being lisinopril). About 70% of orally administered captopril is absorbed. Bioavailability is reduced by presence of food in stomach. It is partly metabolised and partly excreted unchanged in urine. Captopril also has a relatively poor pharmacokinetic profile. The short half-life necessitates dosing two or three times per day, which may reduce patient compliance. Captopril has a short half-life of 2–3 hours and a duration of action of 12–24 hours.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Capoten and Weed and an increase in anxiety.
Anyone mixing Capoten and weed is likely to experience side effects. This happens with all medications whether weed or Capoten is mixed with them. Side effects can be harmful when mixing Capoten and weed. Doctors are likely to refuse a patient a Capoten prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Capoten and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Capoten are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Capoten. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Capoten and Weed, dol not interact is wrong. There will always be an interaction between Capoten and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Capoten and Weed is Scromiting. This condition, reportedly caused by mixing Capoten and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Capoten and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Capoten and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Capoten?
The way in which the body absorbs and process Capoten may be affected by weed. Therefore, the potency of the Capoten may be less effective. Marijuana inhibits the metabolization of Capoten. Not having the right potency of Capoten means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Capoten medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Capoten medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Capoten and Weed
Many individuals may not realize that there are side effects and consequences to mixing Capoten and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Capoten and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Capoten and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Capoten and Weed is not recommended.
Taking Capoten and Weed together
People who take Capoten and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Capoten and weed depend on whether you consume more weed in relation to Capoten or more Capoten in relation to weed.
The use of significantly more weed and Capoten will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Capoten may experience effects such as:
- reduced motor reflexes from Capoten and Weed
- dizziness from Weed and Capoten
- nausea and vomiting due to Capoten and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Capoten leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Capoten
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Capoten this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Capoten affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Capoten and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Capoten can be just as harmful and there is no way of knowing exactly how Capoten and weed is going to affect an individual before they take it.
Taking Capoten and weed together
People who take Capoten and weed together will experience the effects of both substances. The use of significantly more Capoten with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Capoten may experience effects such as:
- reduced motor reflexes from Capoten and weed
- dizziness from weed and Capoten
- nausea and vomiting of the Capoten
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Capoten leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Capoten
Taking Capoten in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Capoten and weed may have difficulty forming new memories. With weed vs Capoten in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Capoten when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Capoten and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Capoten Vs Weed
Studies investigating the effects of drugs such as Capoten and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Capoten and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Capoten together.
When a small to medium amount of weed is combined with Capoten, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Capoten.
How long after taking Capoten can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Capoten has totally cleared your system before taking weed, even in small quantities.
Overdose on Capoten and weed
In the case of Overdose on Capoten or if you are worried after mixing Capoten and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Capoten or mixed weed with Capoten then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Capoten and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Capoten and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Capoten and weed. These individuals may not realize that there are side effects and consequences to consuming both Capoten, marijuana and a range of antidepressants.
Studies on weed, Capoten and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Capoten
A lot of people suffer from depression caused by weed and Capoten. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Capoten and weed
Quitting weed to take Capoten
Medical professionals say an individual prescribed or taking Capoten should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Capoten.
A person beginning to use Capoten should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Capoten can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Capoten may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Capoten and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Capoten or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Capoten from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Capoten.
If you take Capoten, and also drink Alcohol or MDMA, you can research the effects of Capoten and Alcohol , Capoten and Cocaine as well as Capoten and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Capoten and Weed
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