Caplyta and Weed
Edited by Hugh Soames
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Caplyta and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Caplyta. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Caplyta and Weed.
Mixing Caplyta and Weed
Lumateperone, sold under the brand name Caplyta, is an atypical antipsychotic medication of the butyrophenone class. It is approved for the treatment of schizophrenia as well as bipolar depression, as either monotherapy or adjunctive therapy (with lithium or valproate). It is developed by Intra-Cellular Therapies, licensed from Bristol-Myers Squibb. Lumateperone was approved for medical use in the United States in December 2019 with an initial indication for schizophrenia, and became available in February 2020. It has since demonstrated efficacy in bipolar depression and received FDA approval in December 2021 for depressive episodes associated with both bipolar I and II disorders.
On December 20, 2019, the United States Food and Drug Administration (FDA) approved lumateperone for the treatment of schizophrenia in adults.
In December 2021, the FDA approved lumateperone for the treatment of bipolar depression in adults as monotherapy and as adjunctive therapy with lithium or valproate. The number needed to treat (NNT) for bipolar depression at a dose of 42mg daily is 7 patients.
Lumateperone acts as a receptor antagonist of 5-HT2A receptor and antagonizes several dopamine receptors (D1, D2, and D4) with lower affinity. It has moderate serotonin transporter reuptake inhibition. It has additional off-target antagonism at alpha-1 receptors, without appreciable antimuscarinic or antihistaminergic properties, limiting side effects associated with other atypical antipsychotics.
After taking the medication by mouth, lumateperone reaches maximum plasma concentrations within 1–2 hours and has a terminal elimination half-life of 18 hours. Lumateperone is a substrate for numerous metabolic enzymes, including various glucuronosyltransferase (UGT) isoforms (UGT1A1, 1A4, and 2B15), aldo-keto reductase (AKR) isoforms (AKR1C1, 1B10, and 1C4), and cytochrome P450 (CYP) enzymes (CYP3A4, 2C8, and 1A2).
Lumateperone does not cause appreciable inhibition of any common CYP450 enzymes. It is not a substrate for p-glycoprotein.
The FDA approved lumateperone based on evidence from three clinical trials (Trial 1/NCT01499563, Trial 2/NCT02282761 and Trial 3/NCT02469155) that enrolled 818 adult participants with schizophrenia. The trials were conducted at 33 sites in the United States. Trials 1 and 2 provided data on the benefits and side effects of lumateperone, and Trial 3 provided data on side effects only.
Three trials provided data for the approval of lumateperone. In each trial, hospitalized participants with schizophrenia were randomly assigned to receive either lumateperone or a comparison treatment (placebo or active comparator) once daily for four weeks (Trials 1 and 2) or six weeks (Trial 3). Neither the participants nor the health care providers knew which treatment was being given until after the trials were completed.
Trials 1 and 2 provided data for the assessment of benefits and side effects through four weeks of therapy. Benefit was assessed by measuring the overall improvement in the symptoms of schizophrenia. Trial 3 provided data for the assessment of side effects only during six weeks of therapy.
Two Phase III lumateperone monotherapy studies were conducted and completed for the treatment of bipolar depression, those being trial Study 401 and Study 404. A third trial, Study 402, aims to test lumateperone in addition to lithium or valproate, the data pertaining this trial is due out in 2020.
Study 401 was conducted solely in the United States while Study 404 was a global study and included patients from the US. Of the entire Study 404 population (381 patients), two-thirds were from Russia and Colombia. At the completion of the two monotherapy Phase III trials only Study 404 met its primary endpoint and one of its secondary endpoints. In Study 404, patients received 42 mg lumateperone once daily or placebo for six weeks. Study 404 patients saw an improvement of depressive symptoms compared to placebo as documented by a change in MADRS total score of 4.6.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Caplyta and Weed and an increase in anxiety.
Anyone mixing Caplyta and weed is likely to experience side effects. This happens with all medications whether weed or Caplyta is mixed with them. Side effects can be harmful when mixing Caplyta and weed. Doctors are likely to refuse a patient a Caplyta prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Caplyta and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Caplyta are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Caplyta. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Caplyta and Weed, dol not interact is wrong. There will always be an interaction between Caplyta and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Caplyta and Weed is Scromiting. This condition, reportedly caused by mixing Caplyta and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Caplyta and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Caplyta and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Caplyta?
The way in which the body absorbs and process Caplyta may be affected by weed. Therefore, the potency of the Caplyta may be less effective. Marijuana inhibits the metabolization of Caplyta. Not having the right potency of Caplyta means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Caplyta medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Caplyta medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Caplyta and Weed
Many individuals may not realize that there are side effects and consequences to mixing Caplyta and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Caplyta and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Caplyta and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Caplyta and Weed is not recommended.
Taking Caplyta and Weed together
People who take Caplyta and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Caplyta and weed depend on whether you consume more weed in relation to Caplyta or more Caplyta in relation to weed.
The use of significantly more weed and Caplyta will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Caplyta may experience effects such as:
- reduced motor reflexes from Caplyta and Weed
- dizziness from Weed and Caplyta
- nausea and vomiting due to Caplyta and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Caplyta leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Caplyta
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Caplyta this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Caplyta affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Caplyta and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Caplyta can be just as harmful and there is no way of knowing exactly how Caplyta and weed is going to affect an individual before they take it.
Taking Caplyta and weed together
People who take Caplyta and weed together will experience the effects of both substances. The use of significantly more Caplyta with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Caplyta may experience effects such as:
- reduced motor reflexes from Caplyta and weed
- dizziness from weed and Caplyta
- nausea and vomiting of the Caplyta
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Caplyta leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Caplyta
Taking Caplyta in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Caplyta and weed may have difficulty forming new memories. With weed vs Caplyta in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Caplyta when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Caplyta and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Caplyta Vs Weed
Studies investigating the effects of drugs such as Caplyta and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Caplyta and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Caplyta together.
When a small to medium amount of weed is combined with Caplyta, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Caplyta.
How long after taking Caplyta can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Caplyta has totally cleared your system before taking weed, even in small quantities.
Overdose on Caplyta and weed
In the case of Overdose on Caplyta or if you are worried after mixing Caplyta and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Caplyta or mixed weed with Caplyta then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Caplyta and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Caplyta and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Caplyta and weed. These individuals may not realize that there are side effects and consequences to consuming both Caplyta, marijuana and a range of antidepressants.
Studies on weed, Caplyta and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Caplyta
A lot of people suffer from depression caused by weed and Caplyta. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Caplyta and weed
Quitting weed to take Caplyta
Medical professionals say an individual prescribed or taking Caplyta should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Caplyta.
A person beginning to use Caplyta should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Caplyta can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Caplyta may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Caplyta and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Caplyta or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Caplyta from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Caplyta.
If you take Caplyta, and also drink Alcohol or MDMA, you can research the effects of Caplyta and Alcohol , Caplyta and Cocaine as well as Caplyta and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Caplyta and Weed
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