Caffeine Citrate and Weed

Edited by Hugh Soames
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Caffeine Citrate and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Caffeine Citrate. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Caffeine Citrate and Weed.
Mixing Caffeine Citrate and Weed
Caffeine citrate, sold under the brand name Cafcit among others, is a medication used to treat a lack of breathing in premature babies. Specifically it is given to babies who are born at less than 35 weeks or weigh less than 2 kilograms (4.4 lb) once other causes are ruled out. It is given by mouth or slow injection into a vein.
Side effects can include problems feeding, increased heart rate, low blood sugar, necrotizing enterocolitis, and kidney problems. Testing blood caffeine levels is occasionally recommended. Although it is often referred to as a citric acid salt of caffeine, as implied by its name, caffeine citrate in fact consists of cocrystals of the two components. Caffeine citrate is in the xanthine family of medication. It works by stimulating the respiratory centers in the brain.
Caffeine was discovered in 1819. It is on the World Health Organization’s List of Essential Medicines. The intravenous form may also be taken by mouth.
In June 2020, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) recommended the approval of Gencebok. It was approved for use in the European Union in August 2020.
Caffeine citrate is generally the preferred treatment for apnea of prematurity for infants born 28 to 32 weeks or earlier than 28 weeks. It has fewer side effects as compared to theophylline.
Caffeine improves airway function in asthma, increasing forced expiratory volume (FEV1) by 5% to 18%, with this effect lasting for up to four hours.
In method of action, the preparation is identical to that of caffeine base as the citrate counter ion dissociates in water. Doses of caffeine citrate, due to the added weight of the citrate moiety, are understandably higher than with caffeine base, i.e., it takes a larger dose to get the same amount of caffeine. The ratio of therapeutic doses of caffeine base to its citrate salt is typically 1:2. Dosing should therefore be clearly distinguished.
The drug is prepared by combining anhydrous caffeine with citric acid monohydrate and sodium citrate dihydrate. Caffeine citrate cocrystals can take on at least two anhydrous polymorphs.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Caffeine Citrate and Weed and an increase in anxiety.
Anyone mixing Caffeine Citrate and weed is likely to experience side effects. This happens with all medications whether weed or Caffeine Citrate is mixed with them. Side effects can be harmful when mixing Caffeine Citrate and weed. Doctors are likely to refuse a patient a Caffeine Citrate prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Caffeine Citrate and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Caffeine Citrate are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Caffeine Citrate. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Caffeine Citrate and Weed, dol not interact is wrong. There will always be an interaction between Caffeine Citrate and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Caffeine Citrate and Weed is Scromiting. This condition, reportedly caused by mixing Caffeine Citrate and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Caffeine Citrate and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Caffeine Citrate and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Caffeine Citrate?
The way in which the body absorbs and process Caffeine Citrate may be affected by weed. Therefore, the potency of the Caffeine Citrate may be less effective. Marijuana inhibits the metabolization of Caffeine Citrate. Not having the right potency of Caffeine Citrate means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Caffeine Citrate medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Caffeine Citrate medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Caffeine Citrate and Weed
Many individuals may not realize that there are side effects and consequences to mixing Caffeine Citrate and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Caffeine Citrate and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Caffeine Citrate and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Caffeine Citrate and Weed is not recommended.
Taking Caffeine Citrate and Weed together
People who take Caffeine Citrate and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Caffeine Citrate and weed depend on whether you consume more weed in relation to Caffeine Citrate or more Caffeine Citrate in relation to weed.
The use of significantly more weed and Caffeine Citrate will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Caffeine Citrate may experience effects such as:
- reduced motor reflexes from Caffeine Citrate and Weed
- dizziness from Weed and Caffeine Citrate
- nausea and vomiting due to Caffeine Citrate and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Caffeine Citrate leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Caffeine Citrate
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Caffeine Citrate this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Caffeine Citrate affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Caffeine Citrate and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Caffeine Citrate can be just as harmful and there is no way of knowing exactly how Caffeine Citrate and weed is going to affect an individual before they take it.
Taking Caffeine Citrate and weed together
People who take Caffeine Citrate and weed together will experience the effects of both substances. The use of significantly more Caffeine Citrate with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Caffeine Citrate may experience effects such as:
- reduced motor reflexes from Caffeine Citrate and weed
- dizziness from weed and Caffeine Citrate
- nausea and vomiting of the Caffeine Citrate
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Caffeine Citrate leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Caffeine Citrate
Taking Caffeine Citrate in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Caffeine Citrate and weed may have difficulty forming new memories. With weed vs Caffeine Citrate in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Caffeine Citrate when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Caffeine Citrate and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Caffeine Citrate Vs Weed
Studies investigating the effects of drugs such as Caffeine Citrate and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Caffeine Citrate and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Caffeine Citrate together.
When a small to medium amount of weed is combined with Caffeine Citrate, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Caffeine Citrate.
How long after taking Caffeine Citrate can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Caffeine Citrate has totally cleared your system before taking weed, even in small quantities.
Overdose on Caffeine Citrate and weed
In the case of Overdose on Caffeine Citrate or if you are worried after mixing Caffeine Citrate and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Caffeine Citrate or mixed weed with Caffeine Citrate then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Caffeine Citrate and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Caffeine Citrate and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Caffeine Citrate and weed. These individuals may not realize that there are side effects and consequences to consuming both Caffeine Citrate, marijuana and a range of antidepressants.
Studies on weed, Caffeine Citrate and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Caffeine Citrate
A lot of people suffer from depression caused by weed and Caffeine Citrate. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Caffeine Citrate and weed
Quitting weed to take Caffeine Citrate
Medical professionals say an individual prescribed or taking Caffeine Citrate should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Caffeine Citrate.
A person beginning to use Caffeine Citrate should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Caffeine Citrate can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Caffeine Citrate may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Caffeine Citrate and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Caffeine Citrate or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Caffeine Citrate from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Caffeine Citrate.
If you take Caffeine Citrate, and also drink Alcohol or MDMA, you can research the effects of Caffeine Citrate and Alcohol , Caffeine Citrate and Cocaine as well as Caffeine Citrate and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.

Caffeine Citrate and Weed
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