Bumex and Weed
Edited by Hugh Soames
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Bumex and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Bumex. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Bumex and Weed.
Mixing Bumex and Weed
Bumetanide, sold under the brand name Bumex among others, is a medication used to treat swelling and high blood pressure. This includes swelling as a result of heart failure, liver failure, or kidney problems. It may work for swelling when other medications have not. For high blood pressure it is not a preferred treatment. It is taken by mouth, or by injection into a vein or muscle. Effects generally begin within an hour and lasts for about six hours.
Common side effects include dizziness, low blood pressure, low blood potassium, muscle cramps, and kidney problems. Other serious side effects may include hearing loss and low blood platelets. Blood tests are recommended regularly for those on treatment. Safety during pregnancy and breastfeeding is unclear. Bumetanide is a loop diuretic and works by decreasing the reabsorption of sodium by the kidneys.
Bumetanide was patented in 1968 and came into medical use in 1972. It is on the World Health Organization’s List of Essential Medicines. It is available as a generic medication. In 2020, it was the 270th most commonly prescribed medication in the United States, with more than 1 million prescriptions.
It is used to treat swelling and high blood pressure. This includes swelling as a result of heart failure, liver failure, or kidney problems. For high blood pressure it is not a preferred treatment. It is taken by mouth, or by injection into a vein or muscle.
Common side effects include dizziness, low blood pressure, low blood potassium, muscle cramps, and kidney problems. Other serious side effects may include hearing loss and low blood platelets. A large observational study concluded that people with a sulfonamide antibiotic allergy may be allergic to sulfonamide non-antibiotics, such as bumetanide, but this is likely due to certain people being at an increased risk in general to developing allergic reactions rather than cross-reactivity between sulfonamide-containing drugs. In smaller studies, the lack of cross-reactivity between sulfonamide antibiotics and sulfonamide non-antibiotics has been demonstrated.
Safety during pregnancy and breastfeeding is unclear.
Bumetanide is a loop diuretic and works by decreasing the reabsorption of sodium by the kidneys.
The main difference between bumetanide and furosemide is in their bioavailability and potency. About 60% of furosemide is absorbed in the intestine, and there are substantial inter- and intraindividual differences in bioavailability (range 10-90%). About 80% of bumetanide is absorbed, and its absorption does not change when it is taken with food. It is said to be a more predictable diuretic, meaning that the predictable absorption is reflected in a more predictable effect. Bumetanide is 40 times more potent than furosemide for people with normal renal function.
Bumetanide is synthesized from 4-chlorobenzoic acid. In the first stage of synthesis, it undergoes sulfonylchlorination by chlorosulfonic acid, forming 4-chloro-3-chlorosulfonylbenzoic acid, which is further nitrated with nitric acid to 4-chloro-3-chlorosulfonyl-5-nitrobenzoic acid. Reacting this with ammonia gives 5-aminosulfonyl-4-chloro-3-nitrobenzoic acid, which when reacted with sodium phenolate is transformed into 5-amino-sulfonyl-3-nitro-5-phenoxybenzoic acid. Reduction of the nitro group in this product by hydrogen using a palladium on carbon catalyst gives 3-amino-5-aminosulfonyl-5-phenoxybenzoic acid. Finally, reacting this with butyl alcohol in the presence of sulfuric acid, followed by treatment with sodium hydroxide to hydrolyze the butyl ester, gives the desired bumetanide.
It 2008, ESPN reported that four NFL players were being suspended under the steroid policy as a result of taking bumetanide.
Bumetanide was an undisclosed active ingredient in the over-the-counter weight loss supplement StarCaps, which was removed from the market after its presence was discovered by the United States Food and Drug Administration.
In the brain, bumetanide blocks the NKCC1 cation-chloride co-transporter, and thus decreases internal chloride concentration in neurons. In turn, this concentration change makes the action of GABA more hyperpolarizing, which may be useful for treatment of neonatal seizures, which quite often are not responsive to traditional GABA-targeted treatment, such as barbiturates. Bumetanide is therefore under evaluation as a prospective antiepileptic drug.
The drug has also been studied as a treatment for autism.
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Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Bumex and Weed and an increase in anxiety.
Anyone mixing Bumex and weed is likely to experience side effects. This happens with all medications whether weed or Bumex is mixed with them. Side effects can be harmful when mixing Bumex and weed. Doctors are likely to refuse a patient a Bumex prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Bumex and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Bumex are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Bumex. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Bumex and Weed, dol not interact is wrong. There will always be an interaction between Bumex and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Bumex and Weed is Scromiting. This condition, reportedly caused by mixing Bumex and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Bumex and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Bumex and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Bumex?
The way in which the body absorbs and process Bumex may be affected by weed. Therefore, the potency of the Bumex may be less effective. Marijuana inhibits the metabolization of Bumex. Not having the right potency of Bumex means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Bumex medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Bumex medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Bumex and Weed
Many individuals may not realize that there are side effects and consequences to mixing Bumex and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Bumex and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Bumex and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Bumex and Weed is not recommended.
Taking Bumex and Weed together
People who take Bumex and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Bumex and weed depend on whether you consume more weed in relation to Bumex or more Bumex in relation to weed.
The use of significantly more weed and Bumex will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Bumex may experience effects such as:
- reduced motor reflexes from Bumex and Weed
- dizziness from Weed and Bumex
- nausea and vomiting due to Bumex and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Bumex leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Bumex
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Bumex this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Bumex affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Bumex and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Bumex can be just as harmful and there is no way of knowing exactly how Bumex and weed is going to affect an individual before they take it.
Taking Bumex and weed together
People who take Bumex and weed together will experience the effects of both substances. The use of significantly more Bumex with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Bumex may experience effects such as:
- reduced motor reflexes from Bumex and weed
- dizziness from weed and Bumex
- nausea and vomiting of the Bumex
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Bumex leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Bumex
Taking Bumex in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Bumex and weed may have difficulty forming new memories. With weed vs Bumex in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Bumex when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Bumex and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Bumex Vs Weed
Studies investigating the effects of drugs such as Bumex and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Bumex and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Bumex together.
When a small to medium amount of weed is combined with Bumex, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Bumex.
How long after taking Bumex can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Bumex has totally cleared your system before taking weed, even in small quantities.
Overdose on Bumex and weed
In the case of Overdose on Bumex or if you are worried after mixing Bumex and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Bumex or mixed weed with Bumex then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Bumex and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Bumex and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Bumex and weed. These individuals may not realize that there are side effects and consequences to consuming both Bumex, marijuana and a range of antidepressants.
Studies on weed, Bumex and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Bumex
A lot of people suffer from depression caused by weed and Bumex. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Bumex and weed
Quitting weed to take Bumex
Medical professionals say an individual prescribed or taking Bumex should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Bumex.
A person beginning to use Bumex should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Bumex can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Bumex may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Bumex and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Bumex or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Bumex from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Bumex.
If you take Bumex, and also drink Alcohol or MDMA, you can research the effects of Bumex and Alcohol , Bumex and Cocaine as well as Bumex and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Bumex and Weed
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