Brukinsa and Weed

{Fulldrug} and Weed

Authored by Pin Ng PhD

Edited by Hugh Soames

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Brukinsa and Weed

 

Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Brukinsa. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Brukinsa and Weed.

 

Mixing Brukinsa and Weed

 

Zanubrutinib, sold under the brand name Brukinsa, is an anticancer medication used for the treatment of mantle cell lymphoma (MCL), Waldenström’s macroglobulinemia (WM), marginal zone lymphoma (MZL), and chronic lymphocytic leukemia (CLL). Zanubrutinib is classified as a Bruton’s tyrosine kinase (BTK) inhibitor. It is given by mouth.

It was approved for medical use in the United States in November 2019.

Zanubrutinib is indicated for the treatment of adults with mantle cell lymphoma who have received at least one prior therapy, and for the treatment of Waldenström’s macroglobulinemia. It is also indicated for the treatment of adults with relapsed or refractory marginal zone lymphoma who have received at least one anti-CD20-based regimen.

In January 2023, the US Food and Drug Administration (FDA) approved zanubrutinib for chronic lymphocytic leukemia or small lymphocytic lymphoma.

Efficacy was evaluated in BGB-3111-206 (NCT03206970), a phase II open-label, multicenter, single-arm trial of 86 participants with mantle cell lymphoma (MCL) who received at least one prior therapy. Zanubrutinib was given orally at 160 mg twice daily until disease progression or unacceptable toxicity. Efficacy was also assessed in BGB-3111-AU-003 (NCT02343120), a phase I/II, open-label, dose-escalation, global, multicenter, single-arm trial of B‑cell malignancies, including 32 previously treated MCL participants treated with zanubrutinib administered orally at 160 mg twice daily or 320 mg once daily.

The primary efficacy outcome measure in both trials was overall response rate (ORR), as assessed by an independent review committee. In trial BGB-3111-206, FDG-PET scans were required and the ORR was 84% (95% CI: 74, 91), with a complete response rate of 59% (95% CI 48, 70) and a median response duration of 19.5 months (95% CI: 16.6, not estimable). In trial BGB-3111-AU-003, FDG-PET scans were not required and the ORR was 84% (95% CI: 67, 95), with a complete response rate of 22% (95% CI: 9, 40) and a median response duration of 18.5 months (95% CI: 12.6, not estimable). Trial 1 was conducted at 13 sites in China, and Trial 2 was conducted at 25 sites in the United States, United Kingdom, Australia, New Zealand, Italy, and South Korea.

The U.S. Food and Drug Administration (FDA) granted zanubrutinib priority review, accelerated approval, breakthrough therapy designation, and orphan drug designation. The FDA approved zanubrutinib in November 2019, and granted the application for Brukinsa to BeiGene USA Inc.

In August 2021, the FDA approved zanubrutinib for the treatment of Waldenström’s macroglobulinemia and in September 2021, for marginal zone lymphoma (MZL).

Zanubrutinib was investigated in ASPEN (NCT03053440), a randomized, active control, open-label trial, comparing zanubrutinib and ibrutinib in participants with MYD88 L265P mutation (MYD88MUT) WM. Participants in Cohort 1 (n=201) were randomized 1:1 to receive zanubrutinib 160 mg twice daily or ibrutinib 420 mg once daily until disease progression or unacceptable toxicity. Cohort 2 enrolled participants with MYD88 wildtype (MYD88WT) or MYD88 mutation unknown WM (n=26 and 2, respectively) and received zanubrutinib 160 mg twice daily.

Approval of zanubrutinib for marginal zone lymphoma is based on two open-label, multicenter, single-arm trials: BGB-3111-214 (NCT03846427), which evaluated 66 participants with MZL who received at least one prior anti-CD20-based therapy, and BGB-3111-AU-003 (NCT02343120), which included 20 participants with previously treated MZL.

On 16 September 2021, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Brukinsa, intended for the treatment of Waldenström’s macroglobulinaemia (WM). The applicant for this medicinal product is BeiGene Ireland Ltd. Zanubrutinib was approved for medical use in the European Union in November 2021.

 

Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Brukinsa and Weed and an increase in anxiety.

 

Anyone mixing Brukinsa and weed is likely to experience side effects. This happens with all medications whether weed or Brukinsa is mixed with them. Side effects can be harmful when mixing Brukinsa and weed. Doctors are likely to refuse a patient a Brukinsa prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Brukinsa and Weed.

 

Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Brukinsa are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Brukinsa. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Brukinsa and Weed, dol not interact is wrong. There will always be an interaction between Brukinsa and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.

 

One of the milder side effects of mixing Brukinsa and Weed is Scromiting. This condition, reportedly caused by mixing Brukinsa and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Brukinsa and Weed is cannabinoid hyperemesis syndrome, or CHS.  For these reasons, some people choose to quit smoking weed.

 

It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.

 

In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Brukinsa and weed can cause health issues the more a person consumes it.

 

How does Weed effect the potency of Brukinsa?

 

The way in which the body absorbs and process Brukinsa may be affected by weed. Therefore, the potency of the Brukinsa may be less effective. Marijuana inhibits the metabolization of Brukinsa. Not having the right potency of Brukinsa means a person may either have a delay in the relief of their underlying symptoms.

 

A person seeking Brukinsa medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Brukinsa medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.

 

Sideffects of Brukinsa and Weed

 

Many individuals may not realize that there are side effects and consequences to mixing Brukinsa and Weed such as:

 

  • Dizziness
  • Sluggishness
  • Drowsiness
  • Shortness of breath
  • Itching
  • Hives
  • Palpitations
  • Respiratory Depression
  • Cardiac Arrest
  • Coma
  • Seizures
  • Death

 

Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Brukinsa and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Brukinsa and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Brukinsa and Weed is not recommended.

 

Taking Brukinsa and Weed together

 

People who take Brukinsa and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Brukinsa and weed depend on whether you consume more weed in relation to Brukinsa or more Brukinsa in relation to weed.

 

The use of significantly more weed and Brukinsa will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.

 

People who take both weed and Brukinsa may experience effects such as:

 

  • reduced motor reflexes from Brukinsa and Weed
  • dizziness from Weed and Brukinsa
  • nausea and vomiting due to Brukinsa and Weed

 

Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Brukinsa leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.

Mixing weed and Brukinsa

 

The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Brukinsa this primary effect is exaggerated, increasing the strain on the body with unpredictable results.

 

Weed and Brukinsa affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Brukinsa and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Brukinsa can be just as harmful and there is no way of knowing exactly how Brukinsa and weed is going to affect an individual before they take it.

 

Taking Brukinsa and weed together

 

People who take Brukinsa and weed together will experience the effects of both substances. The use of significantly more Brukinsa with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.

 

People who take both weed and Brukinsa may experience effects such as:

 

  • reduced motor reflexes from Brukinsa and weed
  • dizziness from weed and Brukinsa
  • nausea and vomiting of the Brukinsa

 

Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Brukinsa leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.

Weed Vs Brukinsa

 

Taking Brukinsa in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Brukinsa and weed may have difficulty forming new memories. With weed vs Brukinsa in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Brukinsa when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Brukinsa and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.

 

Brukinsa Vs Weed

 

Studies investigating the effects of drugs such as Brukinsa and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Brukinsa and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Brukinsa together.

 

When a small to medium amount of weed is combined with Brukinsa, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Brukinsa.

 

How long after taking Brukinsa can I smoke weed or take edibles?

 

To avoid any residual toxicity it is advisable to wait until the Brukinsa has totally cleared your system before taking weed, even in small quantities.

 

Overdose on Brukinsa and weed

 

In the case of Overdose on Brukinsa or if you are worried after mixing Brukinsa and weed, call a first responder or proceed to the nearest Emergency Room immediately.

 

If you are worried about someone who has taken too much Brukinsa or mixed weed with Brukinsa then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Brukinsa and weed in their system.

 

Excessive Weed intake and result in scromiting, chs, and anxiety disorder.  It is advisable to quit vaping weed if you are feeling these symptoms.

Mixing Brukinsa and weed and antidepressants

 

Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Brukinsa and weed. These individuals may not realize that there are side effects and consequences to consuming both Brukinsa, marijuana and a range of antidepressants.

 

Studies on weed, Brukinsa and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.

 

Self-medicating with Weed and Brukinsa

 

A lot of people suffer from depression caused by weed and Brukinsa. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.

 

Potential side effects from mixing Brukinsa and weed

 

Quitting weed to take Brukinsa

 

Medical professionals say an individual prescribed or taking Brukinsa should not stop using weed cold turkey.  Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Brukinsa.

 

A person beginning to use Brukinsa should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.

 

Weed and Brukinsa can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Brukinsa may include:

 

  • loss of motor skills
  • poor or lack of coordination
  • lowered blood pressure
  • short-term memory loss
  • increased heart rate
  • increased blood pressure
  • anxiety
  • paranoia
  • increased energy
  • increased motivation

 

Mixing Brukinsa and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Brukinsa or other mental health drugs with weed can cause even more unwanted side effects.

 

Mixing drugs and weed conclusion

 

Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Brukinsa from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Brukinsa.

 

If you take Brukinsa, and also drink Alcohol or MDMA, you can research the effects of Brukinsa and Alcohol , Brukinsa and Cocaine as well as Brukinsa and MDMA here.

 

To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.

Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.

 

Brukinsa and Weed

Brukinsa and Weed

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  • 1
    1.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/
  • 2
    2.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/
  • 3
    3.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/