Bisoprolol Fumarate and Weed
Edited by Hugh Soames
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Bisoprolol Fumarate and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Bisoprolol Fumarate. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Bisoprolol Fumarate and Weed.
Mixing Bisoprolol Fumarate and Weed
Bisoprolol, sold under the brand name Zebeta among others, is a beta blocker medication used for heart diseases. This includes tachyarrhythmias, high blood pressure, chest pain from not enough blood flow to the heart, and heart failure. It is taken by mouth.
Common side effects include headache, feeling tired, diarrhea, and swelling in the legs. More severe side effects include worsening asthma, blocking the ability to recognize low blood sugar, and worsening heart failure. There are concerns that use during pregnancy may be harmful to the baby. Bisoprolol is in the beta blocker family of medications and is of the β1 selective type.
Bisoprolol is on the World Health Organization’s List of Essential Medicines. Bisoprolol is available as a generic medication. In 2020, it was the 267th most commonly prescribed medication in the United States, with more than 1 million prescriptions.
Bisoprolol is currently used for prevention of cardiovascular events following a heart attack in patients with risk factors for disease progression, in the management of congestive heart failure with reduced ejection fraction, and as a second-line agent for hypertension.
Bisoprolol may be beneficial in the treatment of high blood pressure, but it is not recommended as a first-line antihypertensive agent. It can be an adjunct to first-line antihypertensive agents in patients with accompanying comorbidities, for example, congestive heart failure, where selected beta blockers can be added in patients who remain mildly to moderately symptomatic despite appropriate doses of an angiotensin-converting-enzyme inhibitor.
In cardiac ischemia, the drug is used to reduce the activity of the heart muscle, thereby reducing its oxygen and nutrient demands and allowing its reduced blood supply to still transport sufficient amounts of oxygen and nutrients to meet its needs.
An overdose of bisoprolol can lead to fatigue, hypotension, hypoglycemia, bronchospasms, and bradycardia. Bronchospasms and hypoglycemia occur because at high doses, the drug can be an antagonist for β2 adrenergic receptors located in the lungs and liver. Bronchospasm occurs due to the blockage of β2 receptors in the lungs. Hypoglycemia occurs due to decreased stimulation of glycogenolysis and gluconeogenesis in the liver via β2 receptors.
Non-selective beta-blockers should be avoided in people with asthma or bronchospasm as they may cause exacerbations and worsening of symptoms. β1 selective beta-blockers like bisoprolol have not been shown to cause an increase in asthma exacerbations, and may be cautiously tried in those with controlled, mild-to-moderate asthma with cardiac comorbidities. A 2014 meta-analysis found that unlike non-selective beta-blockers, β1 selective beta-blockers (bisoprolol) showed only a small impact on lung function, with patients remaining responsive to Salbutamol (β2 -agonist) rescue therapy and endorses the use of bisoprolol in select patients with controlled asthma. This was supported by a 2020 clinical trial where bisoprolol had no significant impact on bronchodilation post Salbutamol administration.
Bisoprolol is cardioprotective because it selectively and competitively blocks catecholamine (adrenaline) stimulation of β1 adrenergic receptors (adrenoreceptors), which are mainly found in the heart muscle cells and heart conduction tissue (cardiospecific), but also found in juxtaglomerular cells in the kidney. Normally, adrenaline and noradrenaline stimulation of the β1 adrenoreceptor activates a signalling cascade (Gs protein and cAMP) which ultimately leads to increased myocardial contractility and increased heart rate of the heart muscle and heart pacemaker, respectively. Bisoprolol competitively blocks the activation of this cascade, so decreases the adrenergic tone/stimulation of the heart muscle and pacemaker cells. Decreased adrenergic tone shows less contractility of heart muscle and lowered heart rate of pacemakers.
Bisoprolol β1-selectivity is especially important in comparison to other nonselective beta blockers. The effects of the drug are limited to areas containing β1 adrenoreceptors, which is mainly the heart and part of the kidney. Bisoprolol, whilst β1 adrenoceptor selective can help patients to avoid certain side-effects associated with non-selective beta-blocker activity at additional adrenoceptors (α1 and β2), it does not signify its superiority in treating beta-blocker indicated cardiac conditions such as heart failure but could prove beneficial to patients with specific comorbidities.
Bisoprolol has a higher degree of β1-selectivity compared to atenolol, metoprolol and betaxolol. With a selectivity ranging from being 11-15 times more selective for β1over β2 However nebivolol is approximately 3.5 times more β1-selective.
Bisoprolol inhibits renin secretion by about 65% and tachycardia by about 30%.
After ingestion, bisoprolol is absorbed and has a high bioavailability of approximately 90% with plasma half-life of 10-12 hours. When being eliminated, the body evenly distributes it (50–50) between kidney excretion and liver biotransformation (then excreted).
Bisoprolol has both lipid- and water-soluble properties.
The plasma protein binding of bisoprolol is approximately 35%, the volume of distribution is 3.5 L/kg and the total clearance is approximately 15 L/h. Bisoprolol is eliminated from the body in two ways – 50% of the substance is converted in the liver to inactive metabolites, which are then excreted in the kidneys. The remaining 50% is eliminated unchanged via the kidneys. Since elimination is equal in liver and kidney, no dose adjustment is required in patients with hepatic or renal impairment.
The pharmacokinetics of bisoprolol are linear and independent of age.
In patients with chronic heart failure, the plasma level of bisoprolol is higher and the half-life is longer than in healthy subjects when compared across studies. Currently, there is a lack of evidence directly comparing bisoprolol pharmacokinetics between healthy subjects and chronic heart failure subjects.
Bisoprolol was patented in 1976 and approved for medical use in 1986. It was approved for medical use in the United States in 1992.
In India, it is sold under trade name Bisotab and is available in 2 strengths of 2.5 mg and 5 mg.
In Italy, it is sold under trade name Congescor and is available in 6 strengths of 1.25 mg, 2.5 mg, 3.75 mg, 5 mg, 7.5 mg and 10 mg.
In Germany and Eastern Europe bisoprolol is marketed as Bisoprolol-ratiopharm by Ratiopharm (Teva).
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Bisoprolol Fumarate and Weed and an increase in anxiety.
Anyone mixing Bisoprolol Fumarate and weed is likely to experience side effects. This happens with all medications whether weed or Bisoprolol Fumarate is mixed with them. Side effects can be harmful when mixing Bisoprolol Fumarate and weed. Doctors are likely to refuse a patient a Bisoprolol Fumarate prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Bisoprolol Fumarate and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Bisoprolol Fumarate are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Bisoprolol Fumarate. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Bisoprolol Fumarate and Weed, dol not interact is wrong. There will always be an interaction between Bisoprolol Fumarate and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Bisoprolol Fumarate and Weed is Scromiting. This condition, reportedly caused by mixing Bisoprolol Fumarate and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Bisoprolol Fumarate and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Bisoprolol Fumarate and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Bisoprolol Fumarate?
The way in which the body absorbs and process Bisoprolol Fumarate may be affected by weed. Therefore, the potency of the Bisoprolol Fumarate may be less effective. Marijuana inhibits the metabolization of Bisoprolol Fumarate. Not having the right potency of Bisoprolol Fumarate means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Bisoprolol Fumarate medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Bisoprolol Fumarate medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Bisoprolol Fumarate and Weed
Many individuals may not realize that there are side effects and consequences to mixing Bisoprolol Fumarate and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Bisoprolol Fumarate and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Bisoprolol Fumarate and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Bisoprolol Fumarate and Weed is not recommended.
Taking Bisoprolol Fumarate and Weed together
People who take Bisoprolol Fumarate and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Bisoprolol Fumarate and weed depend on whether you consume more weed in relation to Bisoprolol Fumarate or more Bisoprolol Fumarate in relation to weed.
The use of significantly more weed and Bisoprolol Fumarate will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Bisoprolol Fumarate may experience effects such as:
- reduced motor reflexes from Bisoprolol Fumarate and Weed
- dizziness from Weed and Bisoprolol Fumarate
- nausea and vomiting due to Bisoprolol Fumarate and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Bisoprolol Fumarate leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Bisoprolol Fumarate
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Bisoprolol Fumarate this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Bisoprolol Fumarate affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Bisoprolol Fumarate and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Bisoprolol Fumarate can be just as harmful and there is no way of knowing exactly how Bisoprolol Fumarate and weed is going to affect an individual before they take it.
Taking Bisoprolol Fumarate and weed together
People who take Bisoprolol Fumarate and weed together will experience the effects of both substances. The use of significantly more Bisoprolol Fumarate with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Bisoprolol Fumarate may experience effects such as:
- reduced motor reflexes from Bisoprolol Fumarate and weed
- dizziness from weed and Bisoprolol Fumarate
- nausea and vomiting of the Bisoprolol Fumarate
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Bisoprolol Fumarate leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Bisoprolol Fumarate
Taking Bisoprolol Fumarate in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Bisoprolol Fumarate and weed may have difficulty forming new memories. With weed vs Bisoprolol Fumarate in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Bisoprolol Fumarate when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Bisoprolol Fumarate and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Bisoprolol Fumarate Vs Weed
Studies investigating the effects of drugs such as Bisoprolol Fumarate and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Bisoprolol Fumarate and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Bisoprolol Fumarate together.
When a small to medium amount of weed is combined with Bisoprolol Fumarate, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Bisoprolol Fumarate.
How long after taking Bisoprolol Fumarate can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Bisoprolol Fumarate has totally cleared your system before taking weed, even in small quantities.
Overdose on Bisoprolol Fumarate and weed
In the case of Overdose on Bisoprolol Fumarate or if you are worried after mixing Bisoprolol Fumarate and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Bisoprolol Fumarate or mixed weed with Bisoprolol Fumarate then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Bisoprolol Fumarate and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Bisoprolol Fumarate and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Bisoprolol Fumarate and weed. These individuals may not realize that there are side effects and consequences to consuming both Bisoprolol Fumarate, marijuana and a range of antidepressants.
Studies on weed, Bisoprolol Fumarate and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Bisoprolol Fumarate
A lot of people suffer from depression caused by weed and Bisoprolol Fumarate. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Bisoprolol Fumarate and weed
Quitting weed to take Bisoprolol Fumarate
Medical professionals say an individual prescribed or taking Bisoprolol Fumarate should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Bisoprolol Fumarate.
A person beginning to use Bisoprolol Fumarate should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Bisoprolol Fumarate can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Bisoprolol Fumarate may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Bisoprolol Fumarate and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Bisoprolol Fumarate or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Bisoprolol Fumarate from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Bisoprolol Fumarate.
If you take Bisoprolol Fumarate, and also drink Alcohol or MDMA, you can research the effects of Bisoprolol Fumarate and Alcohol , Bisoprolol Fumarate and Cocaine as well as Bisoprolol Fumarate and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Bisoprolol Fumarate and Weed
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