BiDil and Weed
Edited by Hugh Soames
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BiDil and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including BiDil. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing BiDil and Weed.
Mixing BiDil and Weed
Hydralazine/isosorbide dinitrate, sold under the brand name Bidil, is a fixed-dose combination medication used to treat self-identified Black people with congestive heart failure. It is a combination of hydralazine hydrochloride (an arteriolar vasodilator) and isosorbide dinitrate (a nitrate vasodilator).
The American Food and Drug Administration (FDA) approved this race-specific medication to treat congestive heart failure in specifically self-identified Black patients. It provoked controversy as the first drug approved by the FDA marketed for a single racial-ethnic group.
From 1980 to 1985, Dr. Jay Cohn of the University of Minnesota led a clinical trial in collaboration with the US Veterans Administration called the Vasodilator-Heart Failure Trial (V-HeFT I) that tested whether the combination of isosorbide dinitrate and hydralazine increased survival in patients with heart failure. The results were promising and a follow-up study, V-HeFT II, tested the novel combination against enalapril. Cohn applied for a patent on the combination treatment, which was issued in 1989 as US Patent 4868179. Cohn then licensed the patent to Medco Pharmaceuticals who went on to prepare a New Drug Application (NDA) to approve BiDil on the basis of the V-HeFT trials.
The V-HeFT data was re-analyzed and found that the drug combination appeared to be more effective in treating self-identified African-Americans. This was a significant finding due to prior studies which showed that African-Americans with congestive heart failure (CHF) appeared to respond less effectively to conventional CHF treatments (particularly ACE inhibitors) than White Americans. A new paper was published on these findings and MedCo filed for a new patent for the drug as a treatment for heart failure specifically in black patients.
The new patent and the old patent were then licensed to a company called NitroMed, which ran a clinical called the African-American Heart Failure Trial (A-HeFT), the results of which were published in 2004 in the New England Journal of Medicine. The clinical trial was stopped early because the drug showed significant benefit; it reduced mortality by 43%, reduced hospitalizations by 39%, and improved quality of life markers in African-American patients with CHF.
On the basis of A-HeFT, the FDA approved BiDil in June 2005. In 2006, the Heart Failure Society of America included the use of the fixed dose combination of isosorbide dinitrate/hydralazine as the standard of care in the treatment of heart failure in blacks.
The new drug application claiming treatment of a single, self-identified racial group raised a storm of controversy. Some hailed the development of BiDil as a breakthrough for Black Americans (such groups included the congressional Black Caucus, the Association of Black Cardiologists, the National Medical Association, and the National Association for the Advancement of Colored People) and a step to addressing the unique health care needs and health disparities of the African American community.
Others who criticized the preliminary studies argued that the original study did not have a significant number of African-American subjects to make the BiDil’s race specific claims, and that the results of only one clinical trial where African-Americans were tested does not provide a full and comprehensive study. Furthermore, critics argued that self-identified racial identifications from patients as an indicator for race during the trials were not a sufficient categorization method because these self-identifications were socially constructed and have no biological connection to genomic data. They argued that the trials represented a new form of scientific racism where race, a socially constructed category, would continue to be present in research as a placeholder for genomic identification.
The A-HeFT trial has been the subject of further criticism due to its study design that failed to include a non-African American test group to control for racial factors. According to Jay Cohn, the pill’s developer, the reason for including only African American test subjects was the lack of funding for doing a trial in the full population.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between BiDil and Weed and an increase in anxiety.
Anyone mixing BiDil and weed is likely to experience side effects. This happens with all medications whether weed or BiDil is mixed with them. Side effects can be harmful when mixing BiDil and weed. Doctors are likely to refuse a patient a BiDil prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of BiDil and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including BiDil are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of BiDil. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, BiDil and Weed, dol not interact is wrong. There will always be an interaction between BiDil and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing BiDil and Weed is Scromiting. This condition, reportedly caused by mixing BiDil and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing BiDil and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and BiDil and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of BiDil?
The way in which the body absorbs and process BiDil may be affected by weed. Therefore, the potency of the BiDil may be less effective. Marijuana inhibits the metabolization of BiDil. Not having the right potency of BiDil means a person may either have a delay in the relief of their underlying symptoms.
A person seeking BiDil medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right BiDil medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of BiDil and Weed
Many individuals may not realize that there are side effects and consequences to mixing BiDil and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix BiDil and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing BiDil and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of BiDil and Weed is not recommended.
Taking BiDil and Weed together
People who take BiDil and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of BiDil and weed depend on whether you consume more weed in relation to BiDil or more BiDil in relation to weed.
The use of significantly more weed and BiDil will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and BiDil may experience effects such as:
- reduced motor reflexes from BiDil and Weed
- dizziness from Weed and BiDil
- nausea and vomiting due to BiDil and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and BiDil leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and BiDil
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with BiDil this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and BiDil affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of BiDil and weed have a greater adverse effect yet leading medical recommendation is that smaller does of BiDil can be just as harmful and there is no way of knowing exactly how BiDil and weed is going to affect an individual before they take it.
Taking BiDil and weed together
People who take BiDil and weed together will experience the effects of both substances. The use of significantly more BiDil with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and BiDil may experience effects such as:
- reduced motor reflexes from BiDil and weed
- dizziness from weed and BiDil
- nausea and vomiting of the BiDil
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and BiDil leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs BiDil
Taking BiDil in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of BiDil and weed may have difficulty forming new memories. With weed vs BiDil in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of BiDil when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of BiDil and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
BiDil Vs Weed
Studies investigating the effects of drugs such as BiDil and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when BiDil and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and BiDil together.
When a small to medium amount of weed is combined with BiDil, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as BiDil.
How long after taking BiDil can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the BiDil has totally cleared your system before taking weed, even in small quantities.
Overdose on BiDil and weed
In the case of Overdose on BiDil or if you are worried after mixing BiDil and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much BiDil or mixed weed with BiDil then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of BiDil and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing BiDil and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use BiDil and weed. These individuals may not realize that there are side effects and consequences to consuming both BiDil, marijuana and a range of antidepressants.
Studies on weed, BiDil and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and BiDil
A lot of people suffer from depression caused by weed and BiDil. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing BiDil and weed
Quitting weed to take BiDil
Medical professionals say an individual prescribed or taking BiDil should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take BiDil.
A person beginning to use BiDil should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and BiDil can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and BiDil may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing BiDil and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing BiDil or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent BiDil from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with BiDil.
If you take BiDil, and also drink Alcohol or MDMA, you can research the effects of BiDil and Alcohol , BiDil and Cocaine as well as BiDil and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
BiDil and Weed
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