Berinert and Weed
Edited by Hugh Soames
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Berinert and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Berinert. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Berinert and Weed.
Mixing Berinert and Weed
C1-inhibitor (C1-inh, C1 esterase inhibitor) is a protease inhibitor belonging to the serpin superfamily. Its main function is the inhibition of the complement system to prevent spontaneous activation but also as the major regulator of the contact system. C1-inhibitor is an acute-phase protein that circulates in blood at levels of around 0.25 g/L. The levels rise ~2-fold during inflammation. C1-inhibitor irreversibly binds to and inactivates C1r and C1s proteases in the C1 complex of classical pathway of complement. MASP-1 and MASP-2 proteases in MBL complexes of the lectin pathway are also inactivated. This way, C1-inhibitor prevents the proteolytic cleavage of later complement components C4 and C2 by C1 and MBL. Although named after its complement inhibitory activity, C1-inhibitor also inhibits proteases of the fibrinolytic, clotting, and kinin pathways. Note that C1-inhibitor is the most important physiological inhibitor of plasma kallikrein, FXIa, and FXIIa.
C1-inhibitor is the largest member among the serpin superfamily of proteins. It can be noted that, unlike most family members, C1-inhibitor has a 2-domain structure. The C-terminal serpin domain is similar to other serpins, which is the part of C1-inhibitor that provides the inhibitory activity. The N-terminal domain (also some times referred to as the N-terminal tail) is not essential for C1-inhibitor to inhibit proteases. This domain has no similarity to other proteins. C1-inhibitor is highly glycosylated, bearing both N- and O-glycans. N-terminal domain is especially heavily glycosylated.
The human C1-inhibitor gene (SERPING1) is located on the eleventh chromosome (11q11-q13.1).
Deficiency of this protein is associated with hereditary angioedema (“hereditary angioneurotic edema”), or swelling due to leakage of fluid from blood vessels into connective tissue. Deficiency of C1-inhibitor permits plasma kallikrein activation, which leads to the production of the vasoactive peptide bradykinin. Also, C4 and C2 cleavage goes unchecked, resulting in auto-activation of the complement system. In its most common form, it presents as marked swelling of the face, mouth and/or airway that occurs spontaneously or to minimal triggers (such as mild trauma), but such swelling can occur in any part of the body. In 85% of the cases, the levels of C1-inhibitor are low, while in 15% the protein circulates in normal amounts but it is dysfunctional. In addition to the episodes of facial swelling and/or abdominal pain, it also predisposes to autoimmune diseases, most markedly lupus erythematosus, due to its consumptive effect on complement factors 3 and 4. Mutations in the gene that codes for C1-inhibitor, SERPING1, may also play a role in the development of age-related macular degeneration. At least 97 disease-causing mutations in this gene have been discovered.
Despite uncontrolled auto-activation, it is important to note that levels of key complement components are low during an acute attack because they are being consumed – indeed, low levels of C4 are a key diagnostic test for hereditary angioedema. This situation is analogous to the low levels of clotting factors found in disseminated intravascular coagulation (DIC).
Blood-derived C1-inhibitor is effective but does carry the risk associated with the use of any human blood product. Cinryze, a pharmaceutical-grade C1-inhibitor, was approved for the use of HAE in 2008 in the US after having been available in Europe for decades. It is a highly purified, pasteurized and nanofiltered plasma-derived C1 esterase inhibitor product; it has been approved for routine prophylaxis against angioedema attacks in adolescent and adult patients with HAE.
A recombinant C1-inhibitor obtained from the milk of transgenic rabbits, conestat alfa (trade name Ruconest), is approved for the treatment of acute HAE attacks in adults.
While C1-inhibitor therapy has been used acutely for more than 35 years in Europe in patients with C1-inhibitor deficiency, new methods of treating acute attacks have emerged: a plasma kallikrein inhibitor and the bradykinin receptor antagonist icatibant.
Other products also have been introduced including plasma-derived products such as Berinert and Haegarda.
The activation of the complement cascade can cause damage to cells, therefore the inhibition of the complement cascade can work as a medicine in certain conditions. When someone has a heart attack, for instance, the lack of oxygen in heart cells causes necrosis in heart cells: Dying heart cells spill their contents in the extracellular environment, which triggers the complement cascade. Activation of the complement cascade attracts phagocytes that leak peroxide and other reagents, which may increase the damage for the surviving heart cells. Inhibition of the complement cascade can decrease this damage.
C1-inhibitor is contained in the human blood; it can, therefore, be isolated from donated blood. Risks of infectious disease transmission (viruses, prions, etc.) and relative expense of isolation prevented widespread use. It is also possible to produce it by recombinant technology, but Escherichia coli (the most commonly used organism for this purpose) lacks the eukaryotic ability to glycosylate proteins; as C1-inhibitor is particularly heavily glycosylated, this sialylated recombinant form would have a short circulatory life (the carbohydrates are not relevant to the inhibitor function). Therefore, C1-inhibitor has also been produced in glycosylated form using transgenic rabbits. This form of recombinant C1-inhibitor also has been given orphan drug status for delayed graft function following organ transplantation and for capillary leakage syndrome.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Berinert and Weed and an increase in anxiety.
Anyone mixing Berinert and weed is likely to experience side effects. This happens with all medications whether weed or Berinert is mixed with them. Side effects can be harmful when mixing Berinert and weed. Doctors are likely to refuse a patient a Berinert prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Berinert and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Berinert are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Berinert. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Berinert and Weed, dol not interact is wrong. There will always be an interaction between Berinert and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Berinert and Weed is Scromiting. This condition, reportedly caused by mixing Berinert and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Berinert and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Berinert and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Berinert?
The way in which the body absorbs and process Berinert may be affected by weed. Therefore, the potency of the Berinert may be less effective. Marijuana inhibits the metabolization of Berinert. Not having the right potency of Berinert means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Berinert medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Berinert medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Berinert and Weed
Many individuals may not realize that there are side effects and consequences to mixing Berinert and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Berinert and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Berinert and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Berinert and Weed is not recommended.
Taking Berinert and Weed together
People who take Berinert and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Berinert and weed depend on whether you consume more weed in relation to Berinert or more Berinert in relation to weed.
The use of significantly more weed and Berinert will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Berinert may experience effects such as:
- reduced motor reflexes from Berinert and Weed
- dizziness from Weed and Berinert
- nausea and vomiting due to Berinert and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Berinert leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Berinert
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Berinert this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Berinert affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Berinert and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Berinert can be just as harmful and there is no way of knowing exactly how Berinert and weed is going to affect an individual before they take it.
Taking Berinert and weed together
People who take Berinert and weed together will experience the effects of both substances. The use of significantly more Berinert with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Berinert may experience effects such as:
- reduced motor reflexes from Berinert and weed
- dizziness from weed and Berinert
- nausea and vomiting of the Berinert
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Berinert leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Berinert
Taking Berinert in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Berinert and weed may have difficulty forming new memories. With weed vs Berinert in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Berinert when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Berinert and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Berinert Vs Weed
Studies investigating the effects of drugs such as Berinert and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Berinert and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Berinert together.
When a small to medium amount of weed is combined with Berinert, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Berinert.
How long after taking Berinert can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Berinert has totally cleared your system before taking weed, even in small quantities.
Overdose on Berinert and weed
In the case of Overdose on Berinert or if you are worried after mixing Berinert and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Berinert or mixed weed with Berinert then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Berinert and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Berinert and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Berinert and weed. These individuals may not realize that there are side effects and consequences to consuming both Berinert, marijuana and a range of antidepressants.
Studies on weed, Berinert and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Berinert
A lot of people suffer from depression caused by weed and Berinert. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Berinert and weed
Quitting weed to take Berinert
Medical professionals say an individual prescribed or taking Berinert should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Berinert.
A person beginning to use Berinert should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Berinert can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Berinert may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Berinert and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Berinert or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Berinert from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Berinert.
If you take Berinert, and also drink Alcohol or MDMA, you can research the effects of Berinert and Alcohol , Berinert and Cocaine as well as Berinert and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Berinert and Weed
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