BenzaClin and Weed
Edited by Hugh Soames
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BenzaClin and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including BenzaClin. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing BenzaClin and Weed.
Mixing BenzaClin and Weed
Clindamycin/benzoyl peroxide is a topical gel used for the treatment of acne. It is a fixed-dose combination of clindamycin, as the phosphate, an antibiotic, and benzoyl peroxide, an antiseptic.
Common side effects include peeling, itching, and dryness of the skin where the gel was applied.
Clindamycin/benzoyl peroxide was approved for medical use in the United States in December 2000. It is available as a generic medication.
The gel is used on the skin to treat light to medium acne vulgaris in people 12 years and older.
There is an average 52% decrease in inflammatory acne lesions by week 12.
The combination is less effective than benzoyl peroxide/salicylic acid after short-term treatment of two to four weeks, but the two treatments showed similar effectiveness after ten to twelve weeks.
Studies on whether or not the use of clindamycin/benzoyl peroxide gels is teratogenic or has adverse effects on nursing infants have not been performed. While oral clindamycin passes into breast milk, no such data are available for clindamycin in gel form. Limited data regarding topical clindamycin and benzoyl peroxide have shown no safety problems.
The gel is not recommended for those who are allergic to clindamycin, benzoyl peroxide, any components of the formulation, or lincomycin. Individuals previously diagnosed with regional enteritis, ulcerative colitis, or antibiotic-associated colitis are also recommended not to use it.
Common side effects are peeling, itching, redness, dryness, burning, and dermatitis. Benzoyl peroxide bleaches hair, clothes, towels, bedclothing, and the like. Prolonged exposure to natural or artificial sun light (UV rays) is not recommended because the gel may cause photosensitivity. Irritation due to benzoyl peroxide can be reduced by avoiding harsh facial cleansers and wearing sunscreen prior to sun exposure.
Clinical studies have shown systemic absorption of clindamycin through topical application, in some cases leading to diarrhea, bloody diarrhea, and colitis. Reports of anaphylaxis were also seen. However, the sources of these reports were personal accounts without controls and of an unknown population, thus it is difficult to attribute their cause to the clindamycin/benzoyl peroxide gel.
No formal interaction studies have been done. Combination with topical products containing alcohol or astringents, as well as skin peelings, may increase the irritant effect of clindamycin/benzoyl peroxide. Topical erythromycin may antagonise the effect of clindamycin, although this has only be demonstrated in in vitro studies. Topical tretinoin and other retinoids may be inactivated by benzoyl peroxide or increase its irritant effect.
Clindamycin phosphate is a water-soluble ester of the semi-synthetic antibiotic clindamycin, which is synthesized from lincomycin. Like the macrolide antibiotics, it acts as a bacteriostatic agent by interfering with the 50S subunit of the ribosome of Cutibacterium acnes, inhibiting bacterial protein synthesis and preventing bacteria from replicating. C. acnes plays a role in the development of acne.
Benzoyl peroxide also kills C. acnes, but by releasing free radical oxygen species, thus oxidizing bacterial proteins. Also, it dries out the area by reducing sebum production, prevents clogged pores, and is a keratolytic agent. Since benzoyl peroxide is an oxidizer, not an antibiotic, it is not subject to C. acnes resistance unlike clindamycin.
Both ingredients have been shown to reduce the number of acne lesions with statistical significance.
Clindamycin phosphate is an inactive prodrug. It is quickly activated to clindamycin by hydrolysis. After four weeks of application during a study, 0.043% of the used clindamycin dose were found in the blood. Benzoyl peroxide is only absorbed through the skin after reduction to benzoic acid, which is subsequently metabolized to hippuric acid and eliminated via the kidneys.
The combination is sold under various brand names including Acanya, Benzaclin, Duac, and Onexton.
Dow Pharmaceuticals filed the patent for Onexton, and the United States Patent and Trademark Office issued the patent on 16 October 2012. On 24 November 2014, the US Food and Drug Administration (FDA) approved the new drug application (NDA) No. 050819 for Onexton, with Dow Pharmaceutical as the holder. The patent is set to expire on 5 August 2029.
On 12 January 2016, Dow Pharmaceutical Sciences and Valeant Pharmaceuticals North America LLC filed a lawsuit against Taro USA and Taro Industries, an Israel-based corporation. The lawsuit was filed for infringement upon their Onexton patent, by Taro attempting to submit an abbreviated new drug application (ANDA) to the Food and Drug Administration (FDA) for its generic 3.75% benzoyl peroxide and 1.2% clindamycin phosphate topical gel. The court concluded that Taro was guilty of attempting to submit an ANDA patent request before the Onexton patent expired. Perrigo settled its patent litigation with Valeant and Dow.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between BenzaClin and Weed and an increase in anxiety.
Anyone mixing BenzaClin and weed is likely to experience side effects. This happens with all medications whether weed or BenzaClin is mixed with them. Side effects can be harmful when mixing BenzaClin and weed. Doctors are likely to refuse a patient a BenzaClin prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of BenzaClin and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including BenzaClin are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of BenzaClin. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, BenzaClin and Weed, dol not interact is wrong. There will always be an interaction between BenzaClin and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing BenzaClin and Weed is Scromiting. This condition, reportedly caused by mixing BenzaClin and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing BenzaClin and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and BenzaClin and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of BenzaClin?
The way in which the body absorbs and process BenzaClin may be affected by weed. Therefore, the potency of the BenzaClin may be less effective. Marijuana inhibits the metabolization of BenzaClin. Not having the right potency of BenzaClin means a person may either have a delay in the relief of their underlying symptoms.
A person seeking BenzaClin medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right BenzaClin medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of BenzaClin and Weed
Many individuals may not realize that there are side effects and consequences to mixing BenzaClin and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix BenzaClin and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing BenzaClin and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of BenzaClin and Weed is not recommended.
Taking BenzaClin and Weed together
People who take BenzaClin and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of BenzaClin and weed depend on whether you consume more weed in relation to BenzaClin or more BenzaClin in relation to weed.
The use of significantly more weed and BenzaClin will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and BenzaClin may experience effects such as:
- reduced motor reflexes from BenzaClin and Weed
- dizziness from Weed and BenzaClin
- nausea and vomiting due to BenzaClin and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and BenzaClin leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and BenzaClin
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with BenzaClin this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and BenzaClin affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of BenzaClin and weed have a greater adverse effect yet leading medical recommendation is that smaller does of BenzaClin can be just as harmful and there is no way of knowing exactly how BenzaClin and weed is going to affect an individual before they take it.
Taking BenzaClin and weed together
People who take BenzaClin and weed together will experience the effects of both substances. The use of significantly more BenzaClin with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and BenzaClin may experience effects such as:
- reduced motor reflexes from BenzaClin and weed
- dizziness from weed and BenzaClin
- nausea and vomiting of the BenzaClin
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and BenzaClin leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs BenzaClin
Taking BenzaClin in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of BenzaClin and weed may have difficulty forming new memories. With weed vs BenzaClin in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of BenzaClin when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of BenzaClin and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
BenzaClin Vs Weed
Studies investigating the effects of drugs such as BenzaClin and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when BenzaClin and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and BenzaClin together.
When a small to medium amount of weed is combined with BenzaClin, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as BenzaClin.
How long after taking BenzaClin can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the BenzaClin has totally cleared your system before taking weed, even in small quantities.
Overdose on BenzaClin and weed
In the case of Overdose on BenzaClin or if you are worried after mixing BenzaClin and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much BenzaClin or mixed weed with BenzaClin then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of BenzaClin and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing BenzaClin and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use BenzaClin and weed. These individuals may not realize that there are side effects and consequences to consuming both BenzaClin, marijuana and a range of antidepressants.
Studies on weed, BenzaClin and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and BenzaClin
A lot of people suffer from depression caused by weed and BenzaClin. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing BenzaClin and weed
Quitting weed to take BenzaClin
Medical professionals say an individual prescribed or taking BenzaClin should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take BenzaClin.
A person beginning to use BenzaClin should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and BenzaClin can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and BenzaClin may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing BenzaClin and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing BenzaClin or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent BenzaClin from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with BenzaClin.
If you take BenzaClin, and also drink Alcohol or MDMA, you can research the effects of BenzaClin and Alcohol , BenzaClin and Cocaine as well as BenzaClin and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
BenzaClin and Weed
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