Azopt and Weed
Edited by Hugh Soames
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Azopt and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Azopt. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Azopt and Weed.
Mixing Azopt and Weed
Brinzolamide (trade name Azopt) is a carbonic anhydrase inhibitor used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
Brinzolamide was approved as a generic medication in the United States in November 2020.
Brinzolamide is a carbonic anhydrase inhibitor (specifically, carbonic anhydrase II). Carbonic anhydrase is found primarily in erythrocytes (but also in other tissues including the eye). It exists as a number of isoenzymes, the most active of which is carbonic anhydrase II (CA-II).
Use for the treatment of open-angle glaucoma and raised intraocular pressure due to either excess aqueous humor production or inadequate drainage of the humor via the trabecular meshwork.
Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion and thus lowers the intraocular pressure in the anterior chamber, presumably by reducing the rate of formation of bicarbonate ions with subsequent reduction in sodium and fluid transport; this may alleviate the effects of open-angle glaucoma.
The recommended frequency for topical application is two times per day. Following ocular instillation, the suspension is systemically absorbed to some degree; however the plasma concentrations are low and generally below the limits of detection (less than 10 ng/mL) due to extensive binding by tissues and erythrocytes. Oral administration is less-favored due to variable absorption from the stomach mucosa and an increased side-effect profile versus ophthalmic administration.
The compound is fairly well protein-bound (60%), but adheres extensively to the carbonic anhydrase-containing erythrocytes. Due to the abundance of readily-bound erythrocytes and minimal known metabolism, Brinzolamide’s whole blood half-life is very long (111 days).
While definitive sites of metabolism have not been firmly established, there are several metabolites worthy of note. N-Desethylbrinzolamide is an active metabolite of the parent compound, and thus exhibits carbonic anhydrase inhibitory activity (largely carbonic anhydrase-I, when in the presence of Brinzolamide) and also accumulates in the erythrocytes. However, Brinzolamide’s other known metabolites (N-Desmethoxypropylbrinzolamide and O-Desmethylbrinzolamide) either have no activity or their activity is currently unknown.
Brinzolamide is excreted primarily unchanged (60%) in the urine, although the renal clearance rate has not been definitively determined. N-Desethylbrinzolamide is also found in the urine along with lower concentrations of the inactive metabolites, N-Desmethoxypropylbrinzolamide and O-Desmethylbrinzolamide; exact levels have not been definitively determined.
The combination of brinzolamide with timolol is marketed under the trade name Azarga. This combination may be more effective than either medication alone.
The combination of brinzolamide with brimonidine is marketed under the trade name Simbrinza. This combination may be more effective than either medication alone.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Azopt and Weed and an increase in anxiety.
Anyone mixing Azopt and weed is likely to experience side effects. This happens with all medications whether weed or Azopt is mixed with them. Side effects can be harmful when mixing Azopt and weed. Doctors are likely to refuse a patient a Azopt prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Azopt and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Azopt are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Azopt. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Azopt and Weed, dol not interact is wrong. There will always be an interaction between Azopt and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Azopt and Weed is Scromiting. This condition, reportedly caused by mixing Azopt and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Azopt and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Azopt and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Azopt?
The way in which the body absorbs and process Azopt may be affected by weed. Therefore, the potency of the Azopt may be less effective. Marijuana inhibits the metabolization of Azopt. Not having the right potency of Azopt means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Azopt medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Azopt medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Azopt and Weed
Many individuals may not realize that there are side effects and consequences to mixing Azopt and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Azopt and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Azopt and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Azopt and Weed is not recommended.
Taking Azopt and Weed together
People who take Azopt and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Azopt and weed depend on whether you consume more weed in relation to Azopt or more Azopt in relation to weed.
The use of significantly more weed and Azopt will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Azopt may experience effects such as:
- reduced motor reflexes from Azopt and Weed
- dizziness from Weed and Azopt
- nausea and vomiting due to Azopt and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Azopt leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Azopt
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Azopt this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Azopt affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Azopt and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Azopt can be just as harmful and there is no way of knowing exactly how Azopt and weed is going to affect an individual before they take it.
Taking Azopt and weed together
People who take Azopt and weed together will experience the effects of both substances. The use of significantly more Azopt with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Azopt may experience effects such as:
- reduced motor reflexes from Azopt and weed
- dizziness from weed and Azopt
- nausea and vomiting of the Azopt
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Azopt leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Azopt
Taking Azopt in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Azopt and weed may have difficulty forming new memories. With weed vs Azopt in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Azopt when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Azopt and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Azopt Vs Weed
Studies investigating the effects of drugs such as Azopt and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Azopt and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Azopt together.
When a small to medium amount of weed is combined with Azopt, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Azopt.
How long after taking Azopt can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Azopt has totally cleared your system before taking weed, even in small quantities.
Overdose on Azopt and weed
In the case of Overdose on Azopt or if you are worried after mixing Azopt and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Azopt or mixed weed with Azopt then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Azopt and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Azopt and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Azopt and weed. These individuals may not realize that there are side effects and consequences to consuming both Azopt, marijuana and a range of antidepressants.
Studies on weed, Azopt and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Azopt
A lot of people suffer from depression caused by weed and Azopt. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Azopt and weed
Quitting weed to take Azopt
Medical professionals say an individual prescribed or taking Azopt should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Azopt.
A person beginning to use Azopt should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Azopt can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Azopt may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Azopt and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Azopt or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Azopt from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Azopt.
If you take Azopt, and also drink Alcohol or MDMA, you can research the effects of Azopt and Alcohol , Azopt and Cocaine as well as Azopt and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Azopt and Weed
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