Azilect and Weed
Edited by Hugh Soames
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Azilect and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Azilect. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Azilect and Weed.
Mixing Azilect and Weed
Rasagiline (Azilect, Azipron) is an irreversible inhibitor of monoamine oxidase-B used as a monotherapy to treat symptoms in early Parkinson’s disease or as an adjunct therapy in more advanced cases.
The racemic form of the drug was invented by Aspro Nicholas in the early 1970s. Moussa B.H. Youdim identified it as a potential drug for Parkinson’s disease, and working with collaborators at Technion – Israel Institute of Technology in Israel and the drug company, Teva Pharmaceuticals, identified the R-isomer as the active form of the drug. Teva brought it to market in partnership with Lundbeck in Europe and Eisai in the US and elsewhere. It was approved in Europe in 2005 and in the US in 2006.
Rasagiline is used to treat symptoms of Parkinson’s disease both alone and in combination with other drugs. It has shown efficacy in both early and advanced Parkinsons, and appears to be especially useful in dealing with non-motor symptoms like fatigue.
Rasagiline has not been tested in pregnant women and is Pregnancy Category C in the US.
The FDA label contains warnings that rasagiline may cause severe hypertension or hypotension, may make people sleepy, may make motor control worse in some people, may cause hallucinations and psychotic-like behavior, may cause impulse control disorder, may increase the risk of melanoma, and upon withdrawal may cause high fever or confusion.
Side effects when the drug is taken alone include flu-like symptoms, joint pain, depression, stomach upset, headache, dizziness, and insomnia. When taken with L-DOPA, side effects include increased movement problems, accidental injury, sudden drops in blood pressure, joint pain and swelling, dry mouth, rash, abnormal dreams and digestive problems including vomiting, loss of appetite, weight loss, abdominal pain, nausea, constipation. When taken with Parkinson’s drugs other than L-DOPA, side effects include peripheral edema, fall, joint pain, cough, and insomnia.
People who are taking meperidine, tramadol, methadone, propoxyphene, dextromethorphan, St. John’s wort, cyclobenzaprine, or another MAO inhibitor should not take rasagiline.
The FDA drug label carries a warning of the risk of serotonin syndrome when rasagiline is used with antidepressants or with meperidine. However the risk appears to be low, based on a multicenter retrospective study in 1504 people, which looked for serotonin syndrome in people with PD who were treated with rasagiline plus antidepressants, rasagiline without antidepressants, or antidepressants plus Parkinson’s drugs other than either rasagiline or selegiline; no cases were identified.
There is a risk of psychosis or bizarre behavior if rasagiline is used with dextromethorphan and there is a risk of non-selective MAO inhibition and hypertensive crisis if rasagiline is used with other MAO inhibitors.
Rasagiline is molecularly a propargylamine derivative. The form brought to market by Teva and its partners is the mesylate salt, and was designated chemically as: 1H-Inden-1-amine-2,3-dihydro-N-2-propynyl-(1R)-methanesulfonate.
Parkinson’s disease is characterized by the death of cells that produce dopamine, a neurotransmitter. An enzyme called monoamine oxidase (MAO) breaks down neurotransmitters. MAO has two forms, MAO-A and MAO-B. MAO-B is generally believed to break down dopamine; however, recent evidence suggests that MAO-A may mostly or entirely be responsible for dopamine metabolism. Rasagiline prevents the breakdown of dopamine by irreversibly binding to MAO-B. Dopamine is therefore more available, somewhat compensating for the diminished quantities made in the brains of people with Parkinson’s.
Selegiline was the first selective MAO-B inhibitor. It is partly metabolized to levomethamphetamine (l-methamphetamine), one of the two enantiomers of methamphetamine, in vivo. While these metabolites may contribute to selegiline’s ability to inhibit reuptake of the neurotransmitters dopamine and norepinephrine, they have also been associated with orthostatic hypotension and hallucinations in some people. Rasagiline metabolizes into 1(R)-aminoindan which has no amphetamine-like characteristics and has neuroprotective properties in cells and in animal models.
It is selective for MAO type B over type A by a factor of fourteen.
Rasagiline is broken down via CYP1A2, part of the cytochrome P450 metabolic path in the liver. It is contraindicated in patients with hepatic insufficiency and its use should be monitored carefully in patients taking other drugs that alter the normal effectiveness of this metabolic path.
Prior to the discovery of rasagiline, a closely related analog called SU-11739 (AGN 1133) was patented. At first, the N-methyl was necessary for the agent to be considered a ring cyclized analog of pargyline with ca. twenty-times the potency. However, the N-methyl compound was a non-selective MAOI.
Racemic rasagiline was discovered and patented by Aspro Nicholas in the 1970s as a drug candidate for treatment of hypertension.
Moussa B. H. Youdim, a biochemist, had been involved in developing selegiline as a drug for Parkinsons, in collaboration with Peter Reiderer. He wanted to find a similar compound that would have fewer side effects, and around 1977, at about the same time he moved from London to Haifa to join the faculty of Technion, he noticed that rasagiline could potentially be such a compound. He called that compound, AGN 1135.
In 1996 Youdim, in collaboration with scientists from Technion and the US National Institutes of Health, and using compounds developed with Teva Pharmaceuticals, published a paper in which the authors wrote that they were inspired by the racemic nature of deprenyl and the greater activity of one of its stereoisomers, L-deprenyl, which became selegiline, to explore the qualities of the isomers of the Aspro compound, and they found that the R-isomer had almost all the activity; this is the compound that became rasagiline. They called the mesylate salt of the R-isomer TVP-1012 and the hydrochloride salt, TVP-101.
Teva and Technion filed patent applications for this racemically pure compound, methods to make it, and methods to use it to treat Parkinsons and other disorders, and Technion eventually assigned its rights to Teva.
Teva began development of rasagiline, and by 1999 was in Phase III trials, and entered into a partnership with Lundbeck in which Lundbeck agreed to share the costs and obtained the joint right to market the drug in Europe. In 2003 Teva partnered with Eisai, giving Eisai the right to jointly market the drug for Parkinson’s in the US, and to co-develop and co-market the drug for Alzheimers and other neurological diseases.
It was approved by the European Medicines Agency for Parkinson’s in 2005 and in the US in 2006.
Rasagiline was tested for efficacy in people with multiple system atrophy in a large randomized, placebo-controlled, double-blind disease-modification trial; the drug failed.
Teva conducted clinical trials attempting to prove that rasagiline did not just treat symptoms, but was a disease-modifying drug – that it actually prevented the death of the dopaminergic neurons that characterize Parkinson’s disease and slowed disease progression. They conducted two clinical trials, called TEMPO and ADAGIO, to try to prove this. The FDA advisory committee rejected their claim in 2011, saying that the clinical trial results did not prove that rasagiline was neuroprotective. The main reason was that in one of the trials, the lower dose was effective at slowing progression, but the higher dose was not, and this made no sense in light of standard dose-response pharmacology.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Azilect and Weed and an increase in anxiety.
Anyone mixing Azilect and weed is likely to experience side effects. This happens with all medications whether weed or Azilect is mixed with them. Side effects can be harmful when mixing Azilect and weed. Doctors are likely to refuse a patient a Azilect prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Azilect and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Azilect are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Azilect. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Azilect and Weed, dol not interact is wrong. There will always be an interaction between Azilect and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Azilect and Weed is Scromiting. This condition, reportedly caused by mixing Azilect and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Azilect and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Azilect and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Azilect?
The way in which the body absorbs and process Azilect may be affected by weed. Therefore, the potency of the Azilect may be less effective. Marijuana inhibits the metabolization of Azilect. Not having the right potency of Azilect means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Azilect medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Azilect medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Azilect and Weed
Many individuals may not realize that there are side effects and consequences to mixing Azilect and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Azilect and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Azilect and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Azilect and Weed is not recommended.
Taking Azilect and Weed together
People who take Azilect and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Azilect and weed depend on whether you consume more weed in relation to Azilect or more Azilect in relation to weed.
The use of significantly more weed and Azilect will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Azilect may experience effects such as:
- reduced motor reflexes from Azilect and Weed
- dizziness from Weed and Azilect
- nausea and vomiting due to Azilect and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Azilect leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Azilect
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Azilect this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Azilect affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Azilect and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Azilect can be just as harmful and there is no way of knowing exactly how Azilect and weed is going to affect an individual before they take it.
Taking Azilect and weed together
People who take Azilect and weed together will experience the effects of both substances. The use of significantly more Azilect with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Azilect may experience effects such as:
- reduced motor reflexes from Azilect and weed
- dizziness from weed and Azilect
- nausea and vomiting of the Azilect
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Azilect leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Azilect
Taking Azilect in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Azilect and weed may have difficulty forming new memories. With weed vs Azilect in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Azilect when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Azilect and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Azilect Vs Weed
Studies investigating the effects of drugs such as Azilect and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Azilect and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Azilect together.
When a small to medium amount of weed is combined with Azilect, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Azilect.
How long after taking Azilect can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Azilect has totally cleared your system before taking weed, even in small quantities.
Overdose on Azilect and weed
In the case of Overdose on Azilect or if you are worried after mixing Azilect and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Azilect or mixed weed with Azilect then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Azilect and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Azilect and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Azilect and weed. These individuals may not realize that there are side effects and consequences to consuming both Azilect, marijuana and a range of antidepressants.
Studies on weed, Azilect and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Azilect
A lot of people suffer from depression caused by weed and Azilect. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Azilect and weed
Quitting weed to take Azilect
Medical professionals say an individual prescribed or taking Azilect should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Azilect.
A person beginning to use Azilect should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Azilect can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Azilect may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Azilect and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Azilect or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Azilect from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Azilect.
If you take Azilect, and also drink Alcohol or MDMA, you can research the effects of Azilect and Alcohol , Azilect and Cocaine as well as Azilect and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Azilect and Weed
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