Azelastine Hydrochloride and Weed
Edited by Hugh Soames
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Azelastine Hydrochloride and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Azelastine Hydrochloride. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Azelastine Hydrochloride and Weed.
Mixing Azelastine Hydrochloride and Weed
Azelastine, sold under the brand name Optivar among others, is a H1 receptor-blocking medication primarily used as a nasal spray to treat allergic rhinitis (hay fever) and as eye drops for allergic conjunctivitis. Other uses may include asthma and skin rashes for which it is taken by mouth. Onset of effects is within minutes when used in the eyes and within an hour when used in the nose. Effects last for up to 12 hours.
Common side effects include headache, sleepiness, change in taste, and sore throat. It is unclear if use is safe during pregnancy or breastfeeding. It is a second-generation antihistamine and works by blocking the release of a number of inflammatory mediators including histamine.
Azelastine was patented in 1971 and came into medical use in 1986. It is available as a generic medication in the United States. In 2020, it was the 173rd most commonly prescribed medication in the United States, with more than 3 million prescriptions.
Azelastine nasal spray is indicated for the local treatment of the symptoms of seasonal allergic rhinitis and perennial allergic rhinitis, such as rhinorrhea, sneezing and nasal pruritus in people five years of age and older. In some countries, it is also indicated for the treatment of vasomotor rhinitis in adults and children ≥ 12 years old. Azelastine eye drops are indicated for the local treatment of seasonal and perennial allergic conjunctivitis.
Azelastine is safe and well tolerated in both adults and children with allergic rhinitis. Bitter taste, headache, nasal burning and somnolence are the most frequently reported adverse events. US prescribing recommendations warn against the concurrent use of alcohol and/or other central nervous system depressants, but to date there have been no studies to assess the effects of azelastine nasal spray on the CNS in humans[needs update?]. More recent studies have shown similar degrees of somnolence (approx. 2%) compared with placebo treatment.
The most common side effect is a bitter taste (about 20% of people). Due to this, the manufacturer has produced another formulation of azelastine with sucralose. The problem of bitter taste may also be reduced by correct application of the nasal spray (i.e. slightly tipping the head forward and not inhaling the medication too deeply), or alternatively using the azelastine/sucralose formulation.
In addition, anosmia (loss in the ability to smell) can occur with nasal spray antihistamines (including both formulations of azelastine).
Azelastine has a triple mode of action:
The systemic bioavailability of azelastine is approximately 40% when administered intranasally. Maximum plasma concentrations (Cmax) are observed within 2–3 hours. The elimination half life, steady-state volume of distribution and plasma clearance are 22 h, 14.5 L/kg and 0.5 L/h/kg respectively (based on intravenous and oral administration data). Approximately 75% of an oral dose is excreted in feces. Pharmacokinetics of orally administered azelastine is not affected by age, gender, or hepatic impairment.
Azelastine is oxidatively metabolized by the cytochrome P450 family into its active metabolite, desmethylazelastine, and two inactive carboxylic acid metabolites.
The chemical nomenclature of azelastine is (±)-1-(2H)-phthalazinone, 4-[(4-chlorophenyl) methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-monohydrochloride. It is white, almost odorless with a bitter taste.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Azelastine Hydrochloride and Weed and an increase in anxiety.
Anyone mixing Azelastine Hydrochloride and weed is likely to experience side effects. This happens with all medications whether weed or Azelastine Hydrochloride is mixed with them. Side effects can be harmful when mixing Azelastine Hydrochloride and weed. Doctors are likely to refuse a patient a Azelastine Hydrochloride prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Azelastine Hydrochloride and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Azelastine Hydrochloride are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Azelastine Hydrochloride. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Azelastine Hydrochloride and Weed, dol not interact is wrong. There will always be an interaction between Azelastine Hydrochloride and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Azelastine Hydrochloride and Weed is Scromiting. This condition, reportedly caused by mixing Azelastine Hydrochloride and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Azelastine Hydrochloride and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Azelastine Hydrochloride and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Azelastine Hydrochloride?
The way in which the body absorbs and process Azelastine Hydrochloride may be affected by weed. Therefore, the potency of the Azelastine Hydrochloride may be less effective. Marijuana inhibits the metabolization of Azelastine Hydrochloride. Not having the right potency of Azelastine Hydrochloride means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Azelastine Hydrochloride medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Azelastine Hydrochloride medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Azelastine Hydrochloride and Weed
Many individuals may not realize that there are side effects and consequences to mixing Azelastine Hydrochloride and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Azelastine Hydrochloride and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Azelastine Hydrochloride and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Azelastine Hydrochloride and Weed is not recommended.
Taking Azelastine Hydrochloride and Weed together
People who take Azelastine Hydrochloride and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Azelastine Hydrochloride and weed depend on whether you consume more weed in relation to Azelastine Hydrochloride or more Azelastine Hydrochloride in relation to weed.
The use of significantly more weed and Azelastine Hydrochloride will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Azelastine Hydrochloride may experience effects such as:
- reduced motor reflexes from Azelastine Hydrochloride and Weed
- dizziness from Weed and Azelastine Hydrochloride
- nausea and vomiting due to Azelastine Hydrochloride and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Azelastine Hydrochloride leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Azelastine Hydrochloride
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Azelastine Hydrochloride this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Azelastine Hydrochloride affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Azelastine Hydrochloride and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Azelastine Hydrochloride can be just as harmful and there is no way of knowing exactly how Azelastine Hydrochloride and weed is going to affect an individual before they take it.
Taking Azelastine Hydrochloride and weed together
People who take Azelastine Hydrochloride and weed together will experience the effects of both substances. The use of significantly more Azelastine Hydrochloride with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Azelastine Hydrochloride may experience effects such as:
- reduced motor reflexes from Azelastine Hydrochloride and weed
- dizziness from weed and Azelastine Hydrochloride
- nausea and vomiting of the Azelastine Hydrochloride
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Azelastine Hydrochloride leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Azelastine Hydrochloride
Taking Azelastine Hydrochloride in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Azelastine Hydrochloride and weed may have difficulty forming new memories. With weed vs Azelastine Hydrochloride in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Azelastine Hydrochloride when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Azelastine Hydrochloride and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Azelastine Hydrochloride Vs Weed
Studies investigating the effects of drugs such as Azelastine Hydrochloride and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Azelastine Hydrochloride and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Azelastine Hydrochloride together.
When a small to medium amount of weed is combined with Azelastine Hydrochloride, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Azelastine Hydrochloride.
How long after taking Azelastine Hydrochloride can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Azelastine Hydrochloride has totally cleared your system before taking weed, even in small quantities.
Overdose on Azelastine Hydrochloride and weed
In the case of Overdose on Azelastine Hydrochloride or if you are worried after mixing Azelastine Hydrochloride and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Azelastine Hydrochloride or mixed weed with Azelastine Hydrochloride then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Azelastine Hydrochloride and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Azelastine Hydrochloride and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Azelastine Hydrochloride and weed. These individuals may not realize that there are side effects and consequences to consuming both Azelastine Hydrochloride, marijuana and a range of antidepressants.
Studies on weed, Azelastine Hydrochloride and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Azelastine Hydrochloride
A lot of people suffer from depression caused by weed and Azelastine Hydrochloride. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Azelastine Hydrochloride and weed
Quitting weed to take Azelastine Hydrochloride
Medical professionals say an individual prescribed or taking Azelastine Hydrochloride should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Azelastine Hydrochloride.
A person beginning to use Azelastine Hydrochloride should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Azelastine Hydrochloride can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Azelastine Hydrochloride may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Azelastine Hydrochloride and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Azelastine Hydrochloride or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Azelastine Hydrochloride from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Azelastine Hydrochloride.
If you take Azelastine Hydrochloride, and also drink Alcohol or MDMA, you can research the effects of Azelastine Hydrochloride and Alcohol , Azelastine Hydrochloride and Cocaine as well as Azelastine Hydrochloride and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Azelastine Hydrochloride and Weed
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