Atgam and Weed
Edited by Hugh Soames
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Atgam and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Atgam. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Atgam and Weed.
Mixing Atgam and Weed
Anti-thymocyte globulin (ATG) is an infusion of horse or rabbit-derived antibodies against human T cells and their precursors (thymocytes), which is used in the prevention and treatment of acute rejection in organ transplantation and therapy of aplastic anemia due to bone marrow insufficiency.
Two antithymocyte globulin (ATG) agents licensed for clinical use in the United States are Thymoglobulin (rabbit ATG, rATG, Genzyme) and Atgam (equine ATG, eATG, Pfizer). Thymoglobulin and Atgam are currently licensed for use in the treatment of renal allograft rejection; Atgam is additionally licensed for use in the treatment of aplastic anemia. Both drugs are used in off-label applications, especially as immunosuppression induction agents before and/or during kidney transplantation. A rabbit anti-T lymphocyte globulin made by Neovii Pharmaceuticals is marketed outside of the United States under the name Grafalon.
ATG administration very substantially reduces immune competence in patients with normal immune systems, through a combination of actions, some explicitly understood and some more hypothetical. rATG in particular effects large reductions (through cell lysis) in the number of circulating T lymphocytes, hence preventing (or at least delaying) the cellular rejection of transplanted organs. However, medical opinion remains divided as to when the benefit of this profound reduction in T cells outweighs the concomitant increased risks of infection and malignancy.
In the United States it is frequently given at the time of the transplant to prevent graft-versus-host disease, although many European centers prefer to reserve its use for the treatment of steroid-resistant acute rejection, as European centres generally serve more homogeneous populations and rejection tends to be less of a problem.[citation needed]
ATG use can induce cytokine release syndrome, and has been thought to increase the risk of post-transplant lymphoproliferative disorder (PTLD); however, this association may not apply when lower dosing regimens are used. There is some evidence to suggest that inducing immunosuppression with rATG at organ transplantation may create conditions in the patient’s immune system favorable to the development of immunological tolerance, but the exact basis for such a development remains largely speculative. Temporary depletion of the T-cell population at the time of the transplant also risks delayed acute rejection, which may be missed and cause severe damage to the graft.
Anti-IL-2Rα receptor antibodies such as basiliximab and daclizumab are increasingly being used in place of ATG as an induction therapy, as they do not cause cytokine release syndrome and (theoretically) improve the development of tolerance.
The cytokine release syndrome associated with ATG administration frequently causes high grade fevers (over 39 °C), chills, and possibly rigors during administration, for which reason steroids (normally methylprednisolone), diphenhydramine 25–50 mg, and acetaminophen 650 mg are usually co-administered. Such adverse reactions can often be controlled by slowing the infusion rate.
The first report of immunizing an animal of one species (guinea pig) against the immune cells of another species (mouse lymphocytes) was by Élie Metchnikoff in 1899. He reported injecting cells recovered from mouse lymph nodes into Guinea pigs and waiting for the immunization to result in the accumulation of anti-mouse antibodies in the Guinea pig blood. When he subsequently collected serum from these Guinea pigs and injected it into normal mice he observed a marked depletion in the number of circulating mouse lymphocytes.
Rabbit ATG has been used in two randomised trials to reduce acute graft versus host disease in recipients receiving progenitor cell transplants.
While higher doses (15 mg/kg) reduced acute graft versus host this was offset by increased infections. However a long term follow up showed that at both high and low (7.5 mg/kg) doses chronic graft versus host was reduced.
A similar trial of anti-lymphocyte globulin showed a trend in reduction of acute graft versus host that was not statistically significant, but a reduction in chronic graft versus host.
The Canadian Blood and Marrow Transplant Group is currently conducting the first randomised trial in chronic graft versus host using an even lower dose of rabbit ATG (4.5 mg/kg) in an attempt to confirm these observations. The endpoint is the reduction in the proportion of patients with chronic graft versus host at 1 year, off immunosuppressants.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Atgam and Weed and an increase in anxiety.
Anyone mixing Atgam and weed is likely to experience side effects. This happens with all medications whether weed or Atgam is mixed with them. Side effects can be harmful when mixing Atgam and weed. Doctors are likely to refuse a patient a Atgam prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Atgam and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Atgam are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Atgam. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Atgam and Weed, dol not interact is wrong. There will always be an interaction between Atgam and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Atgam and Weed is Scromiting. This condition, reportedly caused by mixing Atgam and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Atgam and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Atgam and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Atgam?
The way in which the body absorbs and process Atgam may be affected by weed. Therefore, the potency of the Atgam may be less effective. Marijuana inhibits the metabolization of Atgam. Not having the right potency of Atgam means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Atgam medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Atgam medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Atgam and Weed
Many individuals may not realize that there are side effects and consequences to mixing Atgam and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Atgam and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Atgam and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Atgam and Weed is not recommended.
Taking Atgam and Weed together
People who take Atgam and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Atgam and weed depend on whether you consume more weed in relation to Atgam or more Atgam in relation to weed.
The use of significantly more weed and Atgam will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Atgam may experience effects such as:
- reduced motor reflexes from Atgam and Weed
- dizziness from Weed and Atgam
- nausea and vomiting due to Atgam and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Atgam leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Atgam
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Atgam this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Atgam affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Atgam and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Atgam can be just as harmful and there is no way of knowing exactly how Atgam and weed is going to affect an individual before they take it.
Taking Atgam and weed together
People who take Atgam and weed together will experience the effects of both substances. The use of significantly more Atgam with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Atgam may experience effects such as:
- reduced motor reflexes from Atgam and weed
- dizziness from weed and Atgam
- nausea and vomiting of the Atgam
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Atgam leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Atgam
Taking Atgam in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Atgam and weed may have difficulty forming new memories. With weed vs Atgam in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Atgam when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Atgam and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Atgam Vs Weed
Studies investigating the effects of drugs such as Atgam and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Atgam and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Atgam together.
When a small to medium amount of weed is combined with Atgam, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Atgam.
How long after taking Atgam can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Atgam has totally cleared your system before taking weed, even in small quantities.
Overdose on Atgam and weed
In the case of Overdose on Atgam or if you are worried after mixing Atgam and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Atgam or mixed weed with Atgam then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Atgam and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Atgam and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Atgam and weed. These individuals may not realize that there are side effects and consequences to consuming both Atgam, marijuana and a range of antidepressants.
Studies on weed, Atgam and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Atgam
A lot of people suffer from depression caused by weed and Atgam. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Atgam and weed
Quitting weed to take Atgam
Medical professionals say an individual prescribed or taking Atgam should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Atgam.
A person beginning to use Atgam should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Atgam can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Atgam may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Atgam and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Atgam or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Atgam from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Atgam.
If you take Atgam, and also drink Alcohol or MDMA, you can research the effects of Atgam and Alcohol , Atgam and Cocaine as well as Atgam and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Atgam and Weed
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