Argatroban and Weed
Edited by Hugh Soames
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Argatroban and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Argatroban. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Argatroban and Weed.
Mixing Argatroban and Weed
Argatroban is an anticoagulant that is a small molecule direct thrombin inhibitor. In 2000, argatroban was licensed by the Food and Drug Administration (FDA) for prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia (HIT). In 2002, it was approved for use during percutaneous coronary interventions in patients who have HIT or are at risk for developing it. In 2012, it was approved by the MHRA in the UK for anticoagulation in patients with heparin-induced thrombocytopenia Type II (HIT) who require parenteral antithrombotic therapy.
Argatroban is given intravenously and drug plasma concentrations reach steady state in 1–3 hours. Argatroban is metabolized in the liver and has a half-life of about 50 minutes. It is monitored by PTT. Because of its hepatic metabolism, it may be used in patients with renal dysfunction. (This is in contrast to lepirudin, a direct thrombin inhibitor that is primarily renally cleared).
Argatroban is used as an anticoagulant in individuals with thrombosis and heparin-induced thrombocytopenia. Often these individuals require long-term anticoagulation. If warfarin is chosen as the long-term anticoagulant, this poses particular challenges due to the falsely elevated prothrombin time and INR caused by argatroban. The combination of argatroban and warfarin may raise the INR to greater than 5.0 without a significant increased risk of bleeding complications. One solution to this problem is to measure the chromogenic factor X level. A level < 40–45% typically indicates that the INR will be therapeutic (2–3) when the argatroban is discontinued.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Argatroban and Weed and an increase in anxiety.
Anyone mixing Argatroban and weed is likely to experience side effects. This happens with all medications whether weed or Argatroban is mixed with them. Side effects can be harmful when mixing Argatroban and weed. Doctors are likely to refuse a patient a Argatroban prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Argatroban and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Argatroban are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Argatroban. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Argatroban and Weed, dol not interact is wrong. There will always be an interaction between Argatroban and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Argatroban and Weed is Scromiting. This condition, reportedly caused by mixing Argatroban and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Argatroban and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Argatroban and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Argatroban?
The way in which the body absorbs and process Argatroban may be affected by weed. Therefore, the potency of the Argatroban may be less effective. Marijuana inhibits the metabolization of Argatroban. Not having the right potency of Argatroban means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Argatroban medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Argatroban medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Argatroban and Weed
Many individuals may not realize that there are side effects and consequences to mixing Argatroban and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Argatroban and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Argatroban and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Argatroban and Weed is not recommended.
Taking Argatroban and Weed together
People who take Argatroban and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Argatroban and weed depend on whether you consume more weed in relation to Argatroban or more Argatroban in relation to weed.
The use of significantly more weed and Argatroban will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Argatroban may experience effects such as:
- reduced motor reflexes from Argatroban and Weed
- dizziness from Weed and Argatroban
- nausea and vomiting due to Argatroban and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Argatroban leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Argatroban
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Argatroban this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Argatroban affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Argatroban and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Argatroban can be just as harmful and there is no way of knowing exactly how Argatroban and weed is going to affect an individual before they take it.
Taking Argatroban and weed together
People who take Argatroban and weed together will experience the effects of both substances. The use of significantly more Argatroban with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Argatroban may experience effects such as:
- reduced motor reflexes from Argatroban and weed
- dizziness from weed and Argatroban
- nausea and vomiting of the Argatroban
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Argatroban leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Argatroban
Taking Argatroban in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Argatroban and weed may have difficulty forming new memories. With weed vs Argatroban in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Argatroban when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Argatroban and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Argatroban Vs Weed
Studies investigating the effects of drugs such as Argatroban and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Argatroban and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Argatroban together.
When a small to medium amount of weed is combined with Argatroban, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Argatroban.
How long after taking Argatroban can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Argatroban has totally cleared your system before taking weed, even in small quantities.
Overdose on Argatroban and weed
In the case of Overdose on Argatroban or if you are worried after mixing Argatroban and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Argatroban or mixed weed with Argatroban then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Argatroban and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Argatroban and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Argatroban and weed. These individuals may not realize that there are side effects and consequences to consuming both Argatroban, marijuana and a range of antidepressants.
Studies on weed, Argatroban and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Argatroban
A lot of people suffer from depression caused by weed and Argatroban. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Argatroban and weed
Quitting weed to take Argatroban
Medical professionals say an individual prescribed or taking Argatroban should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Argatroban.
A person beginning to use Argatroban should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Argatroban can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Argatroban may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Argatroban and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Argatroban or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Argatroban from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Argatroban.
If you take Argatroban, and also drink Alcohol or MDMA, you can research the effects of Argatroban and Alcohol , Argatroban and Cocaine as well as Argatroban and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Argatroban and Weed
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