Apresoline and Weed
Edited by Hugh Soames
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Apresoline and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Apresoline. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Apresoline and Weed.
Mixing Apresoline and Weed
Hydralazine, sold under the brand name Apresoline among others, is a medication used to treat high blood pressure and heart failure. This includes high blood pressure in pregnancy and very high blood pressure resulting in symptoms. It has been found to be particularly useful in heart failure, together with isosorbide dinitrate, for treatment of people of African descent. It is given by mouth or by injection into a vein. Effects usually begin around 15 minutes and last up to six hours.
Common side effects include headache and fast heart rate. It is not recommended in people with coronary artery disease or in those with rheumatic heart disease that affects the mitral valve. In those with kidney disease a low dose is recommended. Hydralazine is in the vasodilator family of medications, so it is believed to work by causing the dilation of blood vessels.
Hydralazine was discovered while scientists at Ciba were looking for a treatment for malaria. It was patented in 1949. It is on the World Health Organization’s List of Essential Medicines. In 2020, it was the 103rd most commonly prescribed medication in the United States, with more than 6 million prescriptions.
Hydralazine is not used as a primary drug for treating hypertension because it elicits a reflex sympathetic stimulation of the heart (the baroreceptor reflex). The sympathetic stimulation may increase heart rate and cardiac output, and in people with coronary artery disease may cause angina pectoris or myocardial infarction. Hydralazine may also increase plasma renin concentration, resulting in fluid retention. To prevent these undesirable side effects, hydralazine is usually prescribed in combination with a beta blocker (e.g., propranolol) and a diuretic. Beta-blockers licensed to treat heart failure in the UK include bisoprolol, carvedilol, and nebivolol.
Hydralazine is used to treat severe hypertension, but is not a first-line therapy for essential hypertension. Hydralazine is often used to treat hypertension in pregnancy, though, with either labetalol and/or methyldopa.
Hydralazine is commonly used in combination with isosorbide dinitrate for the treatment of congestive heart failure in black populations. This preparation, isosorbide dinitrate/hydralazine, was the first race-based prescription drug.
It should not be used in people who have tachycardia, heart failure, constrictive pericarditis, lupus, a dissecting aortic aneurysm, or porphyria.
Prolonged treatment may cause a syndrome similar to lupus, which can become fatal if the symptoms are not noticed and drug treatment stopped. Hydralazine is within the top three drugs that is known to induce systemic lupus and this adverse drug event is dose dependent yet significant.
Very common (>10% frequency) side effects include headache, tachycardia, and palpitations.
Common (1–10% frequency) side effects include flushing, hypotension, anginal symptoms, aching or swelling joints, muscle aches, positive tests for atrial natriuretic peptide, stomach upset, diarrhea, nausea and vomiting, and swelling (sodium and water retention).
It may potentiate the antihypertensive effects of:
Drugs subject to a strong first-pass effect such as beta blockers may increase the bioavailability of hydralazine. Epinephrine (adrenaline), by its heart rate-accelerating effects as increased by hydralazine, may lead to toxicity.
Hydralazine is a direct-acting smooth muscle relaxant and acts as a vasodilator primarily in resistance arterioles, also known as the smooth muscle of the arterial bed. The molecular mechanism involves inhibition of inositol trisphosphate-induced Ca release from the sarcoplasmic reticulum in arterial smooth muscle cells. By relaxing vascular smooth muscle, vasodilators act to decrease peripheral resistance, thereby lowering blood pressure and decreasing afterload.
Metabolic products include the N-acetyl derivative, pyruvic acid hydrazone, and acetone hydrazone, each of which may also contribute to reducing blood pressure.
Hydralazine belongs to the hydrazinophthalazine class of drugs.
The antihypertensive activity of hydralazine was discovered by scientists at Ciba, who were trying to discover drugs to treat malaria; it was initially called C-5968 and 1-hydrazinophthalazine; Ciba’s patent application was filed in 1945 and issued in 1949, and the first scientific publications of its blood pressure-lowering activities appeared in 1950. It was approved by the FDA in 1953.
It was one of the first antihypertensive medications that could be taken by mouth.
Hydralazine has also been studied as a treatment for myelodysplastic syndrome in its capacity as a DNA methyltransferase inhibitor.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Apresoline and Weed and an increase in anxiety.
Anyone mixing Apresoline and weed is likely to experience side effects. This happens with all medications whether weed or Apresoline is mixed with them. Side effects can be harmful when mixing Apresoline and weed. Doctors are likely to refuse a patient a Apresoline prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Apresoline and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Apresoline are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Apresoline. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Apresoline and Weed, dol not interact is wrong. There will always be an interaction between Apresoline and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Apresoline and Weed is Scromiting. This condition, reportedly caused by mixing Apresoline and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Apresoline and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Apresoline and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Apresoline?
The way in which the body absorbs and process Apresoline may be affected by weed. Therefore, the potency of the Apresoline may be less effective. Marijuana inhibits the metabolization of Apresoline. Not having the right potency of Apresoline means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Apresoline medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Apresoline medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Apresoline and Weed
Many individuals may not realize that there are side effects and consequences to mixing Apresoline and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Apresoline and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Apresoline and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Apresoline and Weed is not recommended.
Taking Apresoline and Weed together
People who take Apresoline and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Apresoline and weed depend on whether you consume more weed in relation to Apresoline or more Apresoline in relation to weed.
The use of significantly more weed and Apresoline will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Apresoline may experience effects such as:
- reduced motor reflexes from Apresoline and Weed
- dizziness from Weed and Apresoline
- nausea and vomiting due to Apresoline and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Apresoline leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Apresoline
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Apresoline this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Apresoline affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Apresoline and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Apresoline can be just as harmful and there is no way of knowing exactly how Apresoline and weed is going to affect an individual before they take it.
Taking Apresoline and weed together
People who take Apresoline and weed together will experience the effects of both substances. The use of significantly more Apresoline with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Apresoline may experience effects such as:
- reduced motor reflexes from Apresoline and weed
- dizziness from weed and Apresoline
- nausea and vomiting of the Apresoline
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Apresoline leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Apresoline
Taking Apresoline in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Apresoline and weed may have difficulty forming new memories. With weed vs Apresoline in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Apresoline when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Apresoline and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Apresoline Vs Weed
Studies investigating the effects of drugs such as Apresoline and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Apresoline and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Apresoline together.
When a small to medium amount of weed is combined with Apresoline, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Apresoline.
How long after taking Apresoline can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Apresoline has totally cleared your system before taking weed, even in small quantities.
Overdose on Apresoline and weed
In the case of Overdose on Apresoline or if you are worried after mixing Apresoline and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Apresoline or mixed weed with Apresoline then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Apresoline and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Apresoline and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Apresoline and weed. These individuals may not realize that there are side effects and consequences to consuming both Apresoline, marijuana and a range of antidepressants.
Studies on weed, Apresoline and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Apresoline
A lot of people suffer from depression caused by weed and Apresoline. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Apresoline and weed
Quitting weed to take Apresoline
Medical professionals say an individual prescribed or taking Apresoline should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Apresoline.
A person beginning to use Apresoline should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Apresoline can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Apresoline may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Apresoline and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Apresoline or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Apresoline from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Apresoline.
If you take Apresoline, and also drink Alcohol or MDMA, you can research the effects of Apresoline and Alcohol , Apresoline and Cocaine as well as Apresoline and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Apresoline and Weed
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