Anakinra and Weed
Edited by Hugh Soames
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Anakinra and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Anakinra. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Anakinra and Weed.
Mixing Anakinra and Weed
Anakinra, sold under the brand name Kineret, is a biopharmaceutical medication used to treat rheumatoid arthritis, cryopyrin-associated periodic syndromes, familial Mediterranean fever, and Still’s disease. It is a recombinant and slightly modified version of the human interleukin 1 receptor antagonist protein. It is marketed by Swedish Orphan Biovitrum. Anakinra is administered by subcutaneous injection.
It is used as a second line treatment to manage symptoms of rheumatoid arthritis after treatment with a disease-modifying antirheumatic drug (DMARD) has failed. It can be used in combination with some DMARDs.
It is administered subcutaneously to patients diagnosed with a cryopyrin-associated periodic syndrome, including neonatal-onset multisystem inflammatory disease.
It is used to treat Schnitzler’s syndrome (off label in the US). Its response rate is such that it has been suggested that “Treatment failures should lead to reconsider the diagnosis.”
Off label, it is used to treat systemic juvenile idiopathic arthritis (SJIA), gout, calcium pyrophosphate deposition (CPPD), Behçet’s disease, ankylosing spondylitis, uveitis, and other auto-inflammatory syndromes.
In December 2021, the European Medicines Agency authorized the use of anakinra “to treat COVID-19 in adults with pneumonia requiring supplemental oxygen (low or high flow oxygen) and who are at risk of developing severe respiratory failure, as determined by blood levels of a protein called suPAR (soluble urokinase plasminogen activator receptor) of at least 6 ng per ml.” In November 2022, the United States FDA approved its use under an emergency use authorization “for the treatment of COVID-19 in hospitalized adults with pneumonia requiring supplemental oxygen (low- or high-flow oxygen) who are at risk of progressing to severe respiratory failure and likely to have an elevated plasma soluble urokinase plasminogen activator receptor (suPAR).”
It was not tested in pregnant women, but appeared to be safe in animal studies.
It should not be used in people who have active infections or latent tuberculosis, or who are taking TNF inhibitors.
More than ten percent of people taking Anakinra have injection site reactions, headaches, and have increased cholesterol levels. Recipients have eight percent more patients decrease white blood cells counts, two percent more patients decrease platelets counts, one percent more patients get severe infections[4.5% for patients with asthma compared to 0% placebo patients with asthma]. It is unclear if taking Anakinra increases cancer risk; studies are complicated by the fact that people with rheumatoid arthritis already face higher cancer risk.
Anakinra differs from the sequence of Interleukin 1 receptor antagonist by one methionine amino acid added to its N-terminus; it also differs from the human protein in that it is not glycosylated, as it is manufactured in Escherichia coli.
It was approved for medical use in the US in 2001, and in the European Union in 2002.
In 2018, NHS England published a Clinical Commissioning Policy: Anakinra to treat periodic fevers and autoinflammatory disorders (all ages) allowing Anakinra to be commissioned as a first-line treatment for Schnitzler’s syndrome and in cases where the first-line treatment is not effective for Familial Mediterranean fever, Hyper-IgD syndrome also known as Mevalonate kinase deficiency, and TNF receptor associated periodic syndrome (TRAPS), and a Clinical Commissioning Policy: Anakinra/tocilizumab for the treatment of Adult-Onset Still’s Disease refractory to second-line therapy (adults), allowing Anakinra to be commissioned for adult-onset Still’s disease “as a third line treatment where patients are refractory to steroid-sparing effect DMARDs”.
In December 2020, Anakinra was approved by the US Food and Drug Administration for the treatment of deficiency of the interleukin-1–receptor antagonist (DIRA), a rare autoinflammatory disease of infancy. In 2021, it was announced that the Ministry of Health of the Russian Federation had approved the use of Anakinra for the treatment of CAPS.
In October 2021, NHS England published Clinical Commissioning Policy: Anakinra for Haemophagocytic Lymphohistiocytosis (HLH) for adults and children in all ages, allowing Anakinra to be used in the treatment of HLH.
Anakinra effectively treated meningitis caused by a rare genetic mutation in the gene NALP3 in a 67-year-old man enrolled in the Undiagnosed Diseases Network. Researchers at Johns Hopkins University announced in 2019 that anakinra given to pregnant mice with Zika virus had reduced fetal deaths and birth defects. In November 2019, researchers at the University of Manchester reported that Anakinra might have a use in preventing breast cancer from spreading to the bones.
In 2021, it was reported that Anakinra appeared to reduce the neuropathic pain experienced by patients undergoing chemotherapy with vincristine, saying that “repurposing anakinra may be an effective co-treatment strategy to prevent vincristine-induced peripheral neuropathy”.
A review published in 2022 found that “Anakinra appears to show efficacy for numerous dermatologic conditions, with the strongest evidence for hidradenitis suppurativa, Behçet’s disease, Muckle–Wells syndrome, and SAPHO syndrome.” and concluded that “Overall, anakinra appears to be a promising option in the treatment of numerous dermatologic inflammatory conditions refractory to first line therapies, but further and higher-quality data is needed to clarify its therapeutic role.”
In 2023, researchers at Columbia University explored the effect of Anakinra on the ageing of Hematopoietic stem cells in mice. They concluded “that targeting IL-1 as a key mediator of niche inflammation is a tractable strategy to improve blood production during ageing” and were reported to have said “that their findings could pave the way for science to delay aging and even lengthen the lifespan of humans”.
Anakinra is undergoing multiple clinical trials to treat COVID-19 patients, by targeting mechanisms in patients with hyperinflammation. In 2021 a review and meta-analysis of 9 studies involving 1,119 cases concluded that “Available evidence shows that treatment with anakinra reduces both the need for invasive mechanical ventilation and mortality risk of hospitalized non-intubated patients with COVID-19 without increasing the risk of adverse events.”
As of July 2021, the European Medicines Agency (EMA) is evaluating an application to extend the use of anakinra to include treatment of COVID-19 in adults with pneumonia who are at risk of developing severe respiratory failure (inability of the lungs to work properly). According to study results published in September 2021 in Nature Medicine, hospitalized COVID-19 patients at increased risk for respiratory failure showed significant improvement after treatment with Anakinra.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Anakinra and Weed and an increase in anxiety.
Anyone mixing Anakinra and weed is likely to experience side effects. This happens with all medications whether weed or Anakinra is mixed with them. Side effects can be harmful when mixing Anakinra and weed. Doctors are likely to refuse a patient a Anakinra prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Anakinra and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Anakinra are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Anakinra. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Anakinra and Weed, dol not interact is wrong. There will always be an interaction between Anakinra and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Anakinra and Weed is Scromiting. This condition, reportedly caused by mixing Anakinra and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Anakinra and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Anakinra and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Anakinra?
The way in which the body absorbs and process Anakinra may be affected by weed. Therefore, the potency of the Anakinra may be less effective. Marijuana inhibits the metabolization of Anakinra. Not having the right potency of Anakinra means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Anakinra medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Anakinra medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Anakinra and Weed
Many individuals may not realize that there are side effects and consequences to mixing Anakinra and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Anakinra and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Anakinra and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Anakinra and Weed is not recommended.
Taking Anakinra and Weed together
People who take Anakinra and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Anakinra and weed depend on whether you consume more weed in relation to Anakinra or more Anakinra in relation to weed.
The use of significantly more weed and Anakinra will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Anakinra may experience effects such as:
- reduced motor reflexes from Anakinra and Weed
- dizziness from Weed and Anakinra
- nausea and vomiting due to Anakinra and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Anakinra leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Anakinra
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Anakinra this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Anakinra affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Anakinra and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Anakinra can be just as harmful and there is no way of knowing exactly how Anakinra and weed is going to affect an individual before they take it.
Taking Anakinra and weed together
People who take Anakinra and weed together will experience the effects of both substances. The use of significantly more Anakinra with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Anakinra may experience effects such as:
- reduced motor reflexes from Anakinra and weed
- dizziness from weed and Anakinra
- nausea and vomiting of the Anakinra
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Anakinra leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Anakinra
Taking Anakinra in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Anakinra and weed may have difficulty forming new memories. With weed vs Anakinra in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Anakinra when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Anakinra and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Anakinra Vs Weed
Studies investigating the effects of drugs such as Anakinra and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Anakinra and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Anakinra together.
When a small to medium amount of weed is combined with Anakinra, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Anakinra.
How long after taking Anakinra can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Anakinra has totally cleared your system before taking weed, even in small quantities.
Overdose on Anakinra and weed
In the case of Overdose on Anakinra or if you are worried after mixing Anakinra and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Anakinra or mixed weed with Anakinra then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Anakinra and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Anakinra and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Anakinra and weed. These individuals may not realize that there are side effects and consequences to consuming both Anakinra, marijuana and a range of antidepressants.
Studies on weed, Anakinra and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Anakinra
A lot of people suffer from depression caused by weed and Anakinra. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Anakinra and weed
Quitting weed to take Anakinra
Medical professionals say an individual prescribed or taking Anakinra should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Anakinra.
A person beginning to use Anakinra should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Anakinra can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Anakinra may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Anakinra and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Anakinra or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Anakinra from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Anakinra.
If you take Anakinra, and also drink Alcohol or MDMA, you can research the effects of Anakinra and Alcohol , Anakinra and Cocaine as well as Anakinra and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Anakinra and Weed
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