Alprostadil and Weed
Edited by Hugh Soames
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Alprostadil and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Alprostadil. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Alprostadil and Weed.
Mixing Alprostadil and Weed
Prostaglandin E1 (PGE1), also known as alprostadil, is a naturally occurring prostaglandin which is used as a medication. In infants with congenital heart defects, it is delivered by slow injection into a vein to open the ductus arteriosus until surgery can be carried out. By injection into the penis or placement in the urethra, it is used to treat erectile dysfunction.
Common side effects when given to babies include decreased breathing, fever, and low blood pressure. When used for erectile dysfunction side effects may include penile pain, bleeding at the site of injection, and prolonged erection (priapism). Prostaglandin E1 is in the vasodilator family of medications. It works by opening blood vessels and relaxing smooth muscle.
Prostaglandin E1 was isolated in 1957 and approved for medical use in the United States in 1981. It is on the World Health Organization’s List of Essential Medicines.
Alprostadil is also used in maintaining a patent ductus arteriosus in newborns. This is primarily useful when the threat of premature closure of the ductus arteriosus exists in an infant with ductal-dependent congenital heart disease, including cyanotic lesions (e.g., hypoplastic left heart syndrome, pulmonary atresia/stenosis, tricuspid atresia/stenosis, transposition of the great arteries) and acyanotic lesions (e.g., coarctation of the aorta, critical aortic stenosis, and interrupted aortic arch).
Alprostadil is sold in the United States as urethral suppositories and in injectable form. The suppositories are sold under the brand name Muse. The injectable forms are Edex and Caverject. Muse delivers alprostadil as a penile suppository, inserted into the urethra, at least ten minutes before the erection is needed. Caverject and Edex are similarly fast-acting, but instead are injected by syringe directly into the corpus cavernosum of the penis.
Alprostadil is also available as a generic. The major cost is that it must be mixed by a compounding pharmacy and supplies may be difficult to obtain. The different formulations, including Bimix and Trimix, may include papaverine and/or phentolamine. A typical mix might be 30 mg of papaverine, 2 mg of phentolamine, and 20 μg alprostadil. As a generic, it is much less expensive than the packaged injectables. It is premixed and must be kept refrigerated and the user must load a syringe with the quantity needed.
Most recently, the compound has been made easily accessible in an applicable topical cream form known as Vitaros. Made by Takeda UK Ltd, it is now available in Europe and contains either 200 or 300 micrograms of alprostadil in 100 mg of cream which is directly administered as a topical cream applied to the urethra in a preloaded delivery device. The tip of the device is placed in the urethral meatus and the cream delivered into the urethra. Clinical trials for the treatment showed positive results in over 3000 men that it was tested on, and unlike other sexual dysfunction medication, it is said to be usable by men with diabetes or heart problems and those who have undergone a prostatectomy. It has no known interactions with food, alcohol or other medications making it safer than other treatments containing alprostadil. Similarly to the Bimix and Trimix injections though, it must be kept under cool temperatures.
Prostanoids, including alprostadil, do not reduce the risk of limb amputation but may offer a slight improvement in rest-pain and leg ulcer healing in persons with critical limb ischemia.
Preventative administration of alprostadil may reduce the risk of kidney injury (specifically contrast-induced nephropathy) in persons having cardiac angiography or percutaneous coronary intervention.
Prostaglandin E1 is biosynthesized on an as-needed basis from dihomo-γ-linolenic acid (an omega-6 fatty acid) in healthy humans without coronary artery disease and/or a genetic disorder.
Misoprostol is another synthetic prostaglandin E1 analog used to prevent gastric ulcers when taken on a continuous basis, to treat missed miscarriage, to induce labor, and to induce abortion.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Alprostadil and Weed and an increase in anxiety.
Anyone mixing Alprostadil and weed is likely to experience side effects. This happens with all medications whether weed or Alprostadil is mixed with them. Side effects can be harmful when mixing Alprostadil and weed. Doctors are likely to refuse a patient a Alprostadil prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Alprostadil and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Alprostadil are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Alprostadil. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Alprostadil and Weed, dol not interact is wrong. There will always be an interaction between Alprostadil and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Alprostadil and Weed is Scromiting. This condition, reportedly caused by mixing Alprostadil and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Alprostadil and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Alprostadil and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Alprostadil?
The way in which the body absorbs and process Alprostadil may be affected by weed. Therefore, the potency of the Alprostadil may be less effective. Marijuana inhibits the metabolization of Alprostadil. Not having the right potency of Alprostadil means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Alprostadil medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Alprostadil medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Alprostadil and Weed
Many individuals may not realize that there are side effects and consequences to mixing Alprostadil and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Alprostadil and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Alprostadil and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Alprostadil and Weed is not recommended.
Taking Alprostadil and Weed together
People who take Alprostadil and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Alprostadil and weed depend on whether you consume more weed in relation to Alprostadil or more Alprostadil in relation to weed.
The use of significantly more weed and Alprostadil will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Alprostadil may experience effects such as:
- reduced motor reflexes from Alprostadil and Weed
- dizziness from Weed and Alprostadil
- nausea and vomiting due to Alprostadil and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Alprostadil leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Alprostadil
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Alprostadil this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Alprostadil affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Alprostadil and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Alprostadil can be just as harmful and there is no way of knowing exactly how Alprostadil and weed is going to affect an individual before they take it.
Taking Alprostadil and weed together
People who take Alprostadil and weed together will experience the effects of both substances. The use of significantly more Alprostadil with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Alprostadil may experience effects such as:
- reduced motor reflexes from Alprostadil and weed
- dizziness from weed and Alprostadil
- nausea and vomiting of the Alprostadil
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Alprostadil leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Alprostadil
Taking Alprostadil in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Alprostadil and weed may have difficulty forming new memories. With weed vs Alprostadil in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Alprostadil when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Alprostadil and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Alprostadil Vs Weed
Studies investigating the effects of drugs such as Alprostadil and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Alprostadil and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Alprostadil together.
When a small to medium amount of weed is combined with Alprostadil, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Alprostadil.
How long after taking Alprostadil can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Alprostadil has totally cleared your system before taking weed, even in small quantities.
Overdose on Alprostadil and weed
In the case of Overdose on Alprostadil or if you are worried after mixing Alprostadil and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Alprostadil or mixed weed with Alprostadil then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Alprostadil and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Alprostadil and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Alprostadil and weed. These individuals may not realize that there are side effects and consequences to consuming both Alprostadil, marijuana and a range of antidepressants.
Studies on weed, Alprostadil and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Alprostadil
A lot of people suffer from depression caused by weed and Alprostadil. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Alprostadil and weed
Quitting weed to take Alprostadil
Medical professionals say an individual prescribed or taking Alprostadil should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Alprostadil.
A person beginning to use Alprostadil should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Alprostadil can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Alprostadil may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Alprostadil and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Alprostadil or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Alprostadil from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Alprostadil.
If you take Alprostadil, and also drink Alcohol or MDMA, you can research the effects of Alprostadil and Alcohol , Alprostadil and Cocaine as well as Alprostadil and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Alprostadil and Weed
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