Aloxi and Weed
Edited by Hugh Soames
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Aloxi and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Aloxi. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Aloxi and Weed.
Mixing Aloxi and Weed
Palonosetron, sold under the brand name Aloxi, is used for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is a 5-HT3 antagonist.
Palonosetron is administered intravenously, or as a single oral capsule. It has a longer duration of action than other 5-HT3 antagonists. The oral formulation was approved on August 22, 2008, for prevention of acute CINV alone, as a large clinical trial did not show oral administration to be as effective as intravenous use against delayed CINV. It is on the World Health Organization’s List of Essential Medicines.
The oral combination netupitant/palonosetron is approved for both acute and delayed CINV.
The most common adverse effects are headache, which occurs in 4–11% of patients, and constipation in up to 6% of patients. In less than 1% of patients, other gastrointestinal disorders occur, as well as sleeplessness, first- and second-degree atrioventricular block, muscle pain and shortness of breath. Palonosetron is similarly well tolerated as other 5-HT3 antagonists, and slightly less than placebo.
Palonosetron does not relevantly inhibit or induce cytochrome P450 liver enzymes. There are case reports about serotonin syndrome when the drug is combined with serotonergic substances such as selective serotonin reuptake inhibitors (SSRIs) and serotonin–norepinephrine reuptake inhibitors (SNRIs), two common types of antidepressants.
Palonosetron is a 5-HT3 antagonist, commonly known as a setron. These drugs act by blocking serotonin from binding to the 5-HT3 receptor.
Orally taken palonosetron is absorbed well from the gut and has a bioavailability of 97%. Highest blood plasma levels are reached after 5.1±1.7 hours, independently of food intake, and plasma protein binding is 62%. 40% of the substance are eliminated in the unchanged form, and a further 45–50% are metabolized by the liver enzyme CYP2D6 and to a lesser extent by CYP3A4 and CYP1A2. The two main metabolites, the N-oxide and a hydroxy derivative, have less than 1% of palonosetron’s antagonistic effect and are thus practically inactive.
Palonosetron and its metabolites are mainly (to 80–93%) eliminated via the kidney. Biological half-life in healthy persons was 37±12 hours in a study, and 48±19 hours in cancer patients. In 10% of patients, half-life is over 100 hours. Most other marketed setrons have half-lives in the range of about two to 15 hours.
The substance is solid at room temperature and melts at 87 to 88 °C (189 to 190 °F). The infusions and capsules contain palonosetron hydrochloride, which is also a solid. The hydrochloride is easily soluble in water, soluble in propylene glycol, and slightly soluble in ethanol and isopropyl alcohol.
The molecule has two asymmetric carbon atoms. It is used in form of the pure (S,S)-stereoisomer.
Palonosetron was developed by Helsinn around 2001. In January 2003, Helsinn filed a provisional patent application on palonosetron. Over the next 10 years, Helsinn filed four patent applications that claimed priority to the January 2003 date. Relevant here, Helsinn filed its fourth patent application in 2013. That patent (the ’219 patent) covers a fixed dose of 0.25 mg of palonosetron in a 5 ml solution. While developing the drug, Helsinn entered into a confidential licensing agreement with a company called MGI to sell palonosetron in the United States. This licensing agreement contained chemical information about palonosetron and dosage requirements. However, Helsinn did not file for a patent on palonosetron until two years after they had signed their agreement with MGI.
In 2011 Teva Pharmaceuticals – a generic drug manufacturer- challenged the validity of Helsinn’s patent(s) by filing an application for a generic version of palonosetron with the FDA. Teva claimed that, because Helsinn disclosed/sold the 0.25 mg dose of palonosetron to MGI in 2003, which is more than a year (actually about 2 years) before the priority date of its ‘219 patent, this “secret” sale barred Helsinn from received a patent. This conclusion results from the language of the America Invents Act, which bars patents on inventions, which were “in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention,” 35 U. S. C. §102(a)(1).
The District Court held that the AIA’s “on sale” provision did not apply, because the public disclosure of the agreements did not disclose the 0.25 mg dose. The Federal Circuit reversed, holding that the sale was publicly disclosed, regardless of whether the details of the invention were publicly disclosed in the terms of the sale agreements. The SCOTUS agreed with the Federal Circuit, that in this case a commercial sale to a third party, who is required to keep the invention confidential, nevertheless placed the invention “on sale” under USC §102(a).
HELSINN HEALTHCARE S. A. v. TEVA PHARMACEUTICALS USA, INC.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Aloxi and Weed and an increase in anxiety.
Anyone mixing Aloxi and weed is likely to experience side effects. This happens with all medications whether weed or Aloxi is mixed with them. Side effects can be harmful when mixing Aloxi and weed. Doctors are likely to refuse a patient a Aloxi prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Aloxi and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Aloxi are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Aloxi. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Aloxi and Weed, dol not interact is wrong. There will always be an interaction between Aloxi and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Aloxi and Weed is Scromiting. This condition, reportedly caused by mixing Aloxi and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Aloxi and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Aloxi and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Aloxi?
The way in which the body absorbs and process Aloxi may be affected by weed. Therefore, the potency of the Aloxi may be less effective. Marijuana inhibits the metabolization of Aloxi. Not having the right potency of Aloxi means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Aloxi medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Aloxi medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Aloxi and Weed
Many individuals may not realize that there are side effects and consequences to mixing Aloxi and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Aloxi and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Aloxi and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Aloxi and Weed is not recommended.
Taking Aloxi and Weed together
People who take Aloxi and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Aloxi and weed depend on whether you consume more weed in relation to Aloxi or more Aloxi in relation to weed.
The use of significantly more weed and Aloxi will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Aloxi may experience effects such as:
- reduced motor reflexes from Aloxi and Weed
- dizziness from Weed and Aloxi
- nausea and vomiting due to Aloxi and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Aloxi leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Aloxi
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Aloxi this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Aloxi affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Aloxi and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Aloxi can be just as harmful and there is no way of knowing exactly how Aloxi and weed is going to affect an individual before they take it.
Taking Aloxi and weed together
People who take Aloxi and weed together will experience the effects of both substances. The use of significantly more Aloxi with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Aloxi may experience effects such as:
- reduced motor reflexes from Aloxi and weed
- dizziness from weed and Aloxi
- nausea and vomiting of the Aloxi
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Aloxi leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Aloxi
Taking Aloxi in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Aloxi and weed may have difficulty forming new memories. With weed vs Aloxi in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Aloxi when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Aloxi and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Aloxi Vs Weed
Studies investigating the effects of drugs such as Aloxi and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Aloxi and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Aloxi together.
When a small to medium amount of weed is combined with Aloxi, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Aloxi.
How long after taking Aloxi can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Aloxi has totally cleared your system before taking weed, even in small quantities.
Overdose on Aloxi and weed
In the case of Overdose on Aloxi or if you are worried after mixing Aloxi and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Aloxi or mixed weed with Aloxi then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Aloxi and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Aloxi and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Aloxi and weed. These individuals may not realize that there are side effects and consequences to consuming both Aloxi, marijuana and a range of antidepressants.
Studies on weed, Aloxi and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Aloxi
A lot of people suffer from depression caused by weed and Aloxi. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Aloxi and weed
Quitting weed to take Aloxi
Medical professionals say an individual prescribed or taking Aloxi should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Aloxi.
A person beginning to use Aloxi should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Aloxi can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Aloxi may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Aloxi and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Aloxi or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Aloxi from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Aloxi.
If you take Aloxi, and also drink Alcohol or MDMA, you can research the effects of Aloxi and Alcohol , Aloxi and Cocaine as well as Aloxi and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Aloxi and Weed
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